Displaying all 4 publications

  1. Fitri Fareez, R., Ahmad Nazrun, S., Isa, N.M., Rashidi, M.P.M.
    Medicine & Health, 2020;15(1):5-17.
    Gangguan fungsi ereksi adalah salah satu kesan sampingan metadon yang paling lazim. Gangguan ini menjejaskan lebih daripada separuh populasi pesakit metadon dari segi fungsi seksual mereka. Masalah ini dikaitkan dengan penurunan kualiti hidup yang ketara. Gangguan fungsi ereksi boleh menyebabkan masalah yang lebih besar jika tidak dirawat kerana pesakit mungkin memilih untuk menggunakan rawatan sendiri yang berbahaya seperti menyalahgunakan methamphetamine. Penggunaan dadah untuk mengatasi kesan sampingan metadon boleh menyebabkan gangguan penggunaan dadah ganda yang dapat mengganggu rawatan ketagihan dadah. Untuk mengatasi masalah ini, pengamal dan pesakit memainkan peranan yang penting dalam pengurusan gangguan fungsi ereksi. Kesedaran pesakit mengenai gangguan fungsi ereksi dan impaknya serta intervensi aktif oleh doktor untuk mengesan gangguan fungsi ereksi, adalah penting untuk meningkatkan tingkat pengesanan dan pengurusan gangguan fungsi ereksi. Saringan gangguan fungsi ereksi yang kerap dan faktor risikonya akan membantu mengenalpasti pesakit yang menderita gangguan fungsi ereksi. Pelbagai pilihan rawatan seperti rawatan bupropion, trazodone dan banyak lagi tersedia untuk merawat gangguan fungsi ereksi yang akan diterokai lebih lanjut dalam kajian ini.
  2. Hermizi H, Faizah O, Ima-Nirwana S, Ahmad Nazrun S, Norazlina M
    Calcif. Tissue Int., 2009 Jan;84(1):65-74.
    PMID: 19020790 DOI: 10.1007/s00223-008-9190-x
    This study was conducted to determine the effectiveness of three forms of vitamin E supplements following nicotine treatment on bone histomorphometric parameters in an adult male rat model. Rats were divided into seven groups: baseline (B, killed without treatment), control (C, normal saline for 4 months), nicotine (N, nicotine for 2 months), nicotine cessation (NC), tocotrienol-enhanced fraction (TEF), gamma-tocotrienol (GTT), and alpha-tocopherol (ATF). Treatments for the NC, TEF, GTT, and ATF groups were performed in two phases. For the first 2 months they were given nicotine (7 mg/kg), and for the following 2 months nicotine administration was stopped and treatments with respective vitamin E preparations (60 mg/kg) were commenced except for the NC group, which was allowed to recover without treatment. Rats in the N and NC groups had lower trabecular bone volume, mineral appositional rate (MAR), and bone formation rate (BFR/BS) and higher single labeled surface and osteoclast surface compared to the C group. Vitamin E treatment reversed these nicotine effects. Both the TEF and GTT groups, but not the ATF group, had a significantly higher trabecular thickness but lower eroded surface (ES/BS) than the C group. The tocotrienol-treated groups had lower ES/BS than the ATF group. The GTT group showed a significantly higher MAR and BFR/BS than the TEF and ATF groups. In conclusion, nicotine induced significant bone loss, while vitamin E supplements not only reversed the effects but also stimulated bone formation significantly above baseline values. Tocotrienol was shown to be slightly superior compared to tocopherol. Thus, vitamin E, especially GTT, may have therapeutic potential to repair bone damage caused by chronic smoking.
  3. Mohd Heikal MY, Ahmad Nazrun S, Chua KH, Norzana AG
    Cytotechnology, 2019 Apr;71(2):521-537.
    PMID: 30719603 DOI: 10.1007/s10616-019-00298-2
    The proinflammatory cytokines, metalloproteinases family (MMPs), inflammatory mediators PGE2, COX-2 and NO are the most important group of compounds responsible for the loss of metabolic homeostasis of articular cartilage by promoting catabolic and destructive processes in the pathogenesis of osteoarthritis (OA). Stichopus chloronotus, a marine sea cucumber which is rich in n-3 PUFAs and phenolic compound, may exert a favorable influence on the course of the disease. The objective of this study was to investigate the regeneration and anti-inflammatory potential of S. chloronotus aqueous extract (SCAE) on human OA articular chondrocytes (HOC).

    METHODS: The HOC isolated from knee joint cartilage removed during surgery were cultured with SCAE for 7 days. The effect of SCAE on anabolic and catabolic gene expression was verified by real-time PCR. Monolayer chondrocytes were stained with toluidine blue whereas sGAG, NO and PGE2 production in medium were analyzed by ELISA.

    RESULTS: The HOC cultured in various SCAE have polygonal morphology maintaining their chondrocytes characteristic. SAE supplementation tested was found to be effective pro-chondrogenic, anti-inflammatory and anti-oxidative agents, as evidenced by upregulation of cartilage specific markers collagen type II, aggrecan core protein and sox-9 expression and downregulation of collagen type 1, IL-1, IL-6, IL-8, MMP-1, MMP-3, MMP-13, COX-2, iNOS and PAR-2 expression. The presence of SCAE in the culture was able to increase sGAG and reduce NO and PGE2 production significantly.

    CONCLUSIONS: These results suggested that SCAE demonstrated chondroprotective ability by suppressing catabolic activities, oxidative damage and effectively promoting chondrocytes growth.

  4. Chin KY, Ima-Nirwana S, Isa Naina M, Norazlina M, Ahmad Nazrun S, Norliza M, et al.
    J Clin Densitom, 2012 Jan-Mar;15(1):86-91.
    PMID: 22169197 DOI: 10.1016/j.jocd.2011.09.004
    Quantitative ultrasound (QUS) is a relatively easy, reliable, and safe method for bone status assessment, but reference data for Asian males remain scarce. Our study aimed to determine the values for one QUS parameter, the speed of sound (SOS) at the calcaneus, in Malaysian Chinese men and to determine the association between the SOS and several demographic characteristics, such as age, weight, height, and body mass index. Three hundred forty-eight Malaysian Chinese men aged 40 yr and older were recruited, and their calcaneal QUS value was determined using the CM-200 densitometer (Furuno Electric, Nishinomiya City, Japan). The results indicated a significant correlation between SOS and age, and multiple stepwise regression analysis indicated that age and height were important predictors of SOS. A significant reduction in SOS value was observed when men 60 yr and older were compared with men aged 40-49 yr. Compared with the reference data for Japanese males, Chinese men in Malaysia showed higher SOS values across all the age groups studied. In conclusion, there is an age-related decrease in SOS values in Malaysian Chinese men, and the SOS values established in this study can be used as a reference for future studies.
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