TikTok has become increasingly popular among young people in China and there is growing number of young people who start to pay great attention to their health through this platform. Wuhan is a significant location for this study, since it was the initial epicenter of COVID-19. However, little is known about the extent to which university students in Wuhan, China, rely on TikTok for health-related information and how this affects their preventive health actions in the post-COVID-19 era. Therefore, it is crucial to look into the direct effects of TikTok users' search for health information and their actions to protect their health, as well as the mediating functions of e-health literacy and COVID-19 risk perception. The impact of TikTok as a social media platform on the health-related behaviors of university students was examined using the Media Dependency Theory which explains how media use can have significant effects on individuals' attitudes, beliefs, and behaviors. 426 questionnaires were gathered by cluster sampling from a sample of Wuhan university students. Mplus8 was used to perform structural equation modelling, which looked at the relationships between these variables. The results showed a positive correlation between users' TikTok health information seeking and their health preventive behavior (β = 0.303, p