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Degree of conversion and physicomechanical properties of newly developed flowable composite derived from rice husk using urethane dimethacrylate monomer

Azlisham NAF, Johari Y, Mohamad D, Yhaya MF, Mahmood Z

Proc Inst Mech Eng H, 2023 Dec;237(12):1339-1347.
PMID: 38014749 DOI: 10.1177/09544119231208222

This study evaluated the use of urethane dimethacrylate (UDMA) as a base monomer to prepare the newly developed flowable composite (FC) using nanohybrid silica derived from rice husk in comparison to bisphenol A-glycidyl methacrylate (Bis-GMA) on the degree of conversion and physicomechanical properties. The different loadings of base monomer to diluent monomer were used at the ratio of 40:60, 50:50, and 60:40. The bonding analysis confirmed the presence of nanohybrid silica in the newly developed FC. Independent t-test revealed a statistically significant increase in the degree of conversion, depth of cure and Vickers hardness of the UDMA-based FC, while surface roughness showed comparable results between the two base monomers. In conclusion, UDMA-based FC demonstrated superior performance with 60%-65% conversions, a significantly higher depth of cure exceeding 1 mm which complies with the Internal Standard of Organization 4049 (ISO 4049), and a substantial increase in Vickers hardness numbers compared to Bis-GMA-based FC, making UDMA a suitable alternative to Bis-GMA as a base monomer in the formulation of this newly developed FC derived from rice husk.
Fulltext Comparative analysis of hydrazinyl coumarin derivative incorporation in resin-modified and conventional glass ionomer cement

Azlisham NAF, Rahman FSA, Mahmood Z, Mohamad D, Johari Y, Al-Batayneh OB

J Taibah Univ Med Sci, 2024 Dec;19(6):1119-1129.
PMID: 39758353 DOI: 10.1016/j.jtumed.2024.11.003

OBJECTIVE: The study aimed to conduct a comparative analysis of the effects of incorporating hydrazinyl coumarin derivative (HCD) in resin-modified (RMGIC) and conventional glass ionomer cement (cGIC) on their release profiles and antibacterial properties.
METHOD: Resin-modified GIC, Fuji II LC (F2) and high-fluoride cGIC, Fuji VII (F7) were used as controls. HCD was synthesized in-house, incorporated into both RMGIC and cGICs at 1 % and 2 % weight percentages (w/w), and chemically analyzed using Fourier transform infrared (FTIR) spectroscopy. Then, the F2 containing HCD (GIC-HCD F2) and F7 containing HCD (GIC-HCD F7) were evaluated for HCD and fluoride release profiles using UV Visible spectrophotometer and pH/ISE benchtop fluoridemeter, respectively. The antibacterial properties were assessed against Streptococcus sanguinis using the agar well diffusion method and measurement of bacterial growth turbidity, followed by the observation of the bacterial morphology using scanning electron microscope. The data were statistically analyzed using one-way ANOVA and Bonferroni post-hoc tests.
RESULTS: The FTIR spectra confirmed the presence of HCD in the GIC-HCD matrices. HCD was successfully released from both GIC-HCD F2 and GIC-HCD F7 matrices at both weight percentages. Higher fluoride release and inhibitory zones were observed compared to the control groups, with GIC-HCD F2 having a more significant effect than GIC-HCD F7. Additionally, the incorporation of HCD slowed down the growth of Streptococcus sanguinis and showed remarkable changes in bacterial shape specifically on GIC-HCD F2.
CONCLUSION: The incorporation of HCD into both RMGIC and cGIC improved fluoride release and enhanced the antibacterial activities, with a more significant effect observed in RMGIC compared to cGIC.

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