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  1. Chong CJ, Bakry MM, Hatah E, Mohd Tahir NA, Mustafa N
    J Telemed Telecare, 2023 May 30.
    PMID: 37254516 DOI: 10.1177/1357633X231174933
    INTRODUCTION: The prevalence of non-adherence to antidiabetic treatment remains high despite various efforts. Thus, the positive effects of the antidiabetic treatment cannot be optimised and the disease progresses to complications. This present systematic review and meta-analysis aimed to evaluate the effects of mobile applications (apps) intervention on medication adherence and type 2 diabetes mellitus (T2DM) control.

    METHODS: This research was conducted following the PRISMA guidelines. The databases that had been searched included Web of Science, PubMed, Scopus, Cochrane Library and Ovid from 2017 to 2022. Study characteristics were retrieved and study outcomes such as adherence status and diabetes control were extracted and quantitatively analysed through meta-analysis.

    RESULTS: Eight studies met the final inclusion criteria and were included in the analysis, contributing to a total of 884 subjects. The methodological quality of the included studies was variable. Three studies reported statistically significant improvement in medication adherence through mobile apps intervention. Additionally, the mobile apps intervention proved effective in reducing glycaemic outcomes. As compared to non-mobile apps users, glycated haemoglobin (HbA1c) significantly decreased by 0.36% (95% CI -0.47% to -0.25%), whereas fasting plasma glucose (FPG) significantly decreased by 16.75 mg/dL (95% CI -17.60 mg/dL to -15.80 mg/dL).

    CONCLUSION: Mobile apps intervention had beneficial impacts on medication adherence and glycaemic parameters. Future research should explore the best practical approach for real-world settings.

  2. Chong CJ, Makmor-Bakry M, Hatah E, Mohd Tahir NA, Mustafa N, Capule FR, et al.
    Patient Educ Couns, 2024 Nov 12;131:108547.
    PMID: 39577304 DOI: 10.1016/j.pec.2024.108547
    OBJECTIVES: This qualitative phenomenological study explored the perspectives of type 2 diabetes mellitus (T2DM) outpatients in adopting mobile apps for medication adherence management.

    METHODS: Through 25 semi-structured in-depth interviews, themes were identified using thematic analysis, guided by the Technology Readiness and Acceptance Model (TRAM).

    RESULTS: Anticipated convenience and benefits, openness to new technologies acted as drivers, while limited digital literacy and concerns about data privacy and security served as inhibitors of readiness to adopt health apps. Acceptance was influenced by elements related to medication, patient, healthcare professional, family and app aspects. The identified barriers were related to patient, smartphone and monetary factors. Patients perceived the need to adopt digital apps were for those with poor adherence, complex medication regimen and forgetfulness issues. However, concerns about effectively implementing this approach were noted as T2DM patients were predominantly late middle-aged adults who faced technical challenges, leading to combination approach between digital technology and conventional patient education and counselling.

    CONCLUSION: The findings highlighted the factors influencing patient's readiness, acceptance, and barriers on effective utilisation of digital health solutions in managing adherence issues.

    PRACTICAL IMPLICATIONS: The elements of TRAM provide guidance for strategic actions to enhance digital health technology adoption among T2DM patients.

  3. Chong CJ, Makmor-Bakry M, Hatah E, Mohd Tahir NA, Mustafa N, Capule FR, et al.
    J Diabetes Sci Technol, 2026 Nov;20(6):1843-1853.
    PMID: 40543017 DOI: 10.1177/19322968251349851
    BACKGROUND: Digital app interventions have been shown to enhance medication adherence and self-management of type 2 diabetes mellitus (T2DM), leading to improved glycemic outcomes. Despite the availability and ease of access to these apps, the adoption remains low. Therefore, this study aimed to explore strategies to increase the adoption of mobile apps for medication adherence and T2DM self-management.

    METHODS: This study employed a constructivist grounded theory approach. Data were collected through 30 semi-structured in-depth interviews and then analyzed using thematic analysis to identify the strategies.

    RESULTS: The developed model highlighted five key dimensions: technological, economic, social, behavioral, and environmental strategies. Technological strategies discussed user interface and user experience. Economic strategies stressed the importance of financial support. Meanwhile, social strategies focused on social support and partnership. Behavioral strategies emphasized motivation. Environmental strategies included marketing, patient education, health care professionals' roles, supportive assistance, policy, and evidence-based approach.

    CONCLUSIONS: This study offers actionable insights and a blueprint to increase the adoption of mobile apps for T2DM medication adherence and self-management, which requires the collective and collaborative efforts from different stakeholders. Nevertheless, the self-efficacy of patients remains low, justifying the need for further patient education and empowerment.

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