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  1. Fulltext Developments in the detection of diabetic retinopathy: a state-of-the-art review of computer-aided diagnosis and machine learning methods
    Selvachandran G, Quek SG, Paramesran R, Ding W, Son LH
    Artif Intell Rev, 2023;56(2):915-964.
    PMID: 35498558 DOI: 10.1007/s10462-022-10185-6
    The exponential increase in the number of diabetics around the world has led to an equally large increase in the number of diabetic retinopathy (DR) cases which is one of the major complications caused by diabetes. Left unattended, DR worsens the vision and would lead to partial or complete blindness. As the number of diabetics continue to increase exponentially in the coming years, the number of qualified ophthalmologists need to increase in tandem in order to meet the demand for screening of the growing number of diabetic patients. This makes it pertinent to develop ways to automate the detection process of DR. A computer aided diagnosis system has the potential to significantly reduce the burden currently placed on the ophthalmologists. Hence, this review paper is presented with the aim of summarizing, classifying, and analyzing all the recent development on automated DR detection using fundus images from 2015 up to this date. Such work offers an unprecedentedly thorough review of all the recent works on DR, which will potentially increase the understanding of all the recent studies on automated DR detection, particularly on those that deploys machine learning algorithms. Firstly, in this paper, a comprehensive state-of-the-art review of the methods that have been introduced in the detection of DR is presented, with a focus on machine learning models such as convolutional neural networks (CNN) and artificial neural networks (ANN) and various hybrid models. Each AI will then be classified according to its type (e.g. CNN, ANN, SVM), its specific task(s) in performing DR detection. In particular, the models that deploy CNN will be further analyzed and classified according to some important properties of the respective CNN architectures of each model. A total of 150 research articles related to the aforementioned areas that were published in the recent 5 years have been utilized in this review to provide a comprehensive overview of the latest developments in the detection of DR.

    SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10462-022-10185-6.

  2. Fulltext Cervical Cancer Classification From Pap Smear Images Using Deep Convolutional Neural Network Models
    Tan SL, Selvachandran G, Ding W, Paramesran R, Kotecha K
    Interdiscip Sci, 2024 Mar;16(1):16-38.
    PMID: 37962777 DOI: 10.1007/s12539-023-00589-5
    As one of the most common female cancers, cervical cancer often develops years after a prolonged and reversible pre-cancerous stage. Traditional classification algorithms used for detection of cervical cancer often require cell segmentation and feature extraction techniques, while convolutional neural network (CNN) models demand a large dataset to mitigate over-fitting and poor generalization problems. To this end, this study aims to develop deep learning models for automated cervical cancer detection that do not rely on segmentation methods or custom features. Due to limited data availability, transfer learning was employed with pre-trained CNN models to directly operate on Pap smear images for a seven-class classification task. Thorough evaluation and comparison of 13 pre-trained deep CNN models were performed using the publicly available Herlev dataset and the Keras package in Google Collaboratory. In terms of accuracy and performance, DenseNet-201 is the best-performing model. The pre-trained CNN models studied in this paper produced good experimental results and required little computing time.
  3. Fulltext Generalized Susceptible-Exposed-Infectious-Recovered model and its contributing factors for analysing the death and recovery rates of the COVID-19 pandemic
    Wilta F, Chong ALC, Selvachandran G, Kotecha K, Ding W
    Appl Soft Comput, 2022 Jul;123:108973.
    PMID: 35572359 DOI: 10.1016/j.asoc.2022.108973
    COVID-19 is a highly contagious disease that has infected over 136 million people worldwide with over 2.9 million deaths as of 11 April 2021. In March 2020, the WHO declared COVID-19 as a pandemic and countries began to implement measures to control the spread of the virus. The spread and the death rates of the virus displayed dramatic differences among countries globally, showing that there are several factors affecting its spread and mortality. By utilizing the cumulative number of cases from John Hopkins University, the recovery rate, death rate, and the number of active, recovered, and death cases were simulated to analyse the trends and patterns within the chosen countries. 10 countries from 3 different case severity categories (high cases, medium cases, and low cases) and 5 continents (Asia, North America, South America, Europe, and Oceania) were studied. A generalized SEIR model which considers control measures such as isolation, and preventive measures such as vaccination is applied in this study. This model is able to capture not only the dynamics between the states, but also the time evolution of the states by using the fourth-order-Runge-Kutta process. This study found no significant patterns in the countries under the same case severity category, suggesting that there are other factors contributing to the pattern in these countries. One of the factors influencing the pattern in each country is the population's age. COVID-19 related deaths were found to be notably higher among older people, indicating that countries comprising of a larger proportion of older age groups have an increased risk of experiencing higher death rates. Tighter governmental control measures led to fewer infections and eventually reduced the number of death cases, while increasing the recovery rate, and early implementations were found to be far more effective in controlling the spread of the virus and produced better outcomes.
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