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Sustainable and cost-effective approach for the synthesis of lignin-containing cellulose nanocrystals from oil palm empty fruit bunch

Teh KC, Foo ML, Ooi CW, Leng Chew IM

Chemosphere, 2021 Mar;267:129277.
PMID: 33385850 DOI: 10.1016/j.chemosphere.2020.129277

Cellulose nanocrystals (CNC) have received great research attention since the last few decades due to their extraordinary properties and wide range of applications. In this study, a sustainable and cost-effective method for the synthesis of lignin-containing cellulose nanocrystals (LCNC) from oil palm empty fruit bunch (EFB) is presented. This method is able to retain the lignin in EFB and manifest the properties of lignin. The proposed synthesis process is simpler than the conventional method of producing lignin-coated CNC by first removing the lignin to synthesize CNC followed by the re-coating of lignin on the structure. The samples of LCNC were characterized by transmission electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy and water contact angle analysis. In addition, by altering the acid concentration during acid hydrolysis process (53% - 60% H2SO4), both surface hydrophobicity (66.0° - 75.1°) and length of LCNC (467 nm-177 nm) can be altered wherein a higher concentration of acid resulted in a greater contact angle and a shorter length of LCNC. Cost and energy analysis deduced that the proposed synthesis method saved about 62% of the total material cost and 80% less energy as compared to the synthesis of lignin-coated CNC.
Preparation of black cumin seed oil Pickering nanoemulsion with enhanced stability and antioxidant potential using nanocrystalline cellulose from oil palm empty fruit bunch

Foo ML, Ooi CW, Tan KW, Chew IML

Chemosphere, 2022 Jan;287(Pt 2):132108.
PMID: 34509022 DOI: 10.1016/j.chemosphere.2021.132108

The groundbreaking innovation and industrialization are ushering in a new era where technology development is integrated with the sustainability of materials. Over the decade, nanocrystalline cellulose (NCC) obtained from lignocellulosic biomass had created a great value in various aspects. The abundantly available empty fruit bunch (EFB) in the palm oil industry has motivated us to utilize it as a sustainable alternative for the isolation of NCC, which is a worthwhile opportunity to the waste management of EFB. Taking advantage of the shape anisotropy and amphiphilic character, NCC has been demonstrated as a natural stabilizer for oil-in-water emulsion. In this work, preparation of highly stable Pickering nanoemulsion using black cumin seed oil and NCC was attempted. Black cumin seed oil is a class of plant oil with various nutritional and pharmaceutical benefits. However, its poor solubility could substantially lower the therapeutic effect, and thus, requires a delivery system to overcome this limitation. The role of NCC in the formation of stable Pickering nanoemulsion was investigated. The emulsification process was found crucial to the resulting droplet size, whereas NCC contributed critically to its stabilization. The droplet size obtained from ultrasonication and microfluidization was approximately 400 nm, as examined using transmission electron microscopy. The droplet (oil-to-water = 2:8) has long-term stability against creaming and coalescence for more than six months. The nanoemulsion stabilized by NCC could allow a better absorption by the human body, thereby maximizing the potential of black cumin seed oil in the personal care and food industries.
Surface-modified nanocrystalline cellulose from oil palm empty fruit bunch for effective binding of curcumin

Foo ML, Tan CR, Lim PD, Ooi CW, Tan KW, Chew IML

Int J Biol Macromol, 2019 Oct 01;138:1064-1071.
PMID: 31301392 DOI: 10.1016/j.ijbiomac.2019.07.035

Rod-shape particles have been a good drug carrier due to the long circulatory time, tumor accumulation and high cellular uptake in body. Acid-hydrolysed nanocrystalline cellulose (NCC) from empty fruit bunch exhibited a width of 13-30nm and a length of 150-360nm in rod-shape structure. NCC holds good potential as a bio-based drug carrier owing to its biodegradability and biocompatibility. Fourier-transform infrared spectroscopy results confirmed the binding of curcumin onto the NCC modified with tannic acid (TA) and decylamine (DA). TA-DA modification rendered NCC with a higher level of hydrophobicity, as evidenced by a substantial increase in contact angle from 45° to 73°. The modified NCC had the curcumin-binding efficiency in the range of 95-99%, which is at least twofold higher than the unmodified NCC at any curcumin concentration tested. This remarkable curcumin-binding effciency was comparable to that of commercialized NCC from wood-based origin. This work suggests NCC as a superior and sustainable drug carrier, while TA-DA modification is a promising approach to alter the surface property of NCC for an efficient binding of curcumin.
Educational Intervention for Clinical Judgment Skills

Foo ML, Tang LY, Vimala R, Chui PL, Chong MC

J Contin Educ Nurs, 2017 Aug 01;48(8):347-352.
PMID: 28759691 DOI: 10.3928/00220124-20170712-05

BACKGROUND: Because nurses need to handle a broad range of issues related to patients' health status, it is necessary to make reliable and sound clinical judgments for professional accountability and the patients' safety.
METHOD: A quasi-experimental pre- and posttest design with a control group was used to study the effectiveness of an educational intervention on the clinical judgment skills of 80 RNs from two district hospitals. The change in clinical judgment skills during a 6-week period was evaluated using a complex case-based scenario after the completion of the educational intervention.
RESULTS: The mean scores of clinical judgment skills of the experimental group had significantly improved from 24.15 ± 6.92 to 47.38 ± 7.20. (p < .001). However, only a slight change was seen in mean scores for the control group (23.80 ± 5.77 to 26.50 ± 6.53).
CONCLUSION: The educational intervention was effective postintervention. Continuing nursing education using a traditional and case-based method is recommended to improve clinical judgment skills in clinical settings. J Contin Educ Nurs. 2017;48(8):347-352.
Fulltext Molecular Dynamics Simulation of Nanocellulose-Stabilized Pickering Emulsions

Lee KK, Low DYS, Foo ML, Yu LJ, Choong TSY, Tang SY, et al.

Polymers (Basel), 2021 Feb 23;13(4).
PMID: 33672331 DOI: 10.3390/polym13040668

While the economy is rapidly expanding in most emerging countries, issues coupled with a higher population has created foreseeable tension among food, water, and energy. It is crucial for more sustainable valorization of resources, for instance, nanocellulose, to address the core challenges in environmental sustainability. As the complexity of the system evolved, the timescale of project development has increased exponentially. However, research on the design and operation of integrated nanomaterials, along with energy supply, monitoring, and control infrastructure, has seriously lagged. The development cost of new materials can be significantly reduced by utilizing molecular simulation technology in the design of nanostructured materials. To realize its potential, nanocellulose, an amphiphilic biopolymer with the presence of rich -OH and -CH structural groups, was investigated via molecular dynamics simulation to reveal its full potential as Pickering emulsion stabilizer at the molecular level. This work has successfully quantified the Pickering stabilization mechanism profiles by nanocellulose, and the phenomenon could be visualized in three stages, namely the initial homogenous phase, rapid formation of micelles and coalescence, and lastly the thermodynamic equilibrium of the system. It was also observed that the high bead order was always coupled with a high volume of phase separation activities, through a coarse-grained model within 20,000 time steps. The outcome of this work would be helpful to provide an important perspective for the future design and development of nanocellulose-based emulsion products, which cater for food, cosmeceutical, and pharmaceutical industries.