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  1. Li Y, Soh KL, Jing X, Wei L, Saidi HI, Soh KG
    J Multidiscip Healthc, 2025;18:1655-1678.
    PMID: 40125304 DOI: 10.2147/JMDH.S505135
    PURPOSE: This study aims to conduct a bibliometric analysis of research literature on psychological interventions for stroke survivors published from 2000 to 2024, focusing on psychological resilience and psychological well-being, utilizing VOSviewer and CiteSpace.

    PATIENTS AND METHODS: Literature data was sourced from the Web of Science Core Collection database (WoSCC). A total of 373 relevant articles published between January 1, 2000, and September 30, 2024, were included. CiteSpace and VOSviewer analyzed the literature from perspectives including authorship, country of origin, institutions, journals, references, and keywords.

    RESULTS: Annual publication output has steadily increased, reaching a peak in 2023 (55 articles). Vranceanu Ana-Maria emerged as the most productive author with eight publications. The United States led in research output (98 articles) and centrality (0.32), with Harvard University being the leading institution (24 articles). "Disability and Rehabilitation" was the most productive journal (12 articles), while "Stroke" was the most co-cited journal (241 times). Recent research trends emphasized meta-analysis (strength=3.6), assessment tool validation (strength=3.49), and acceptance-based interventions (strength=2.89), mainly focusing on psychological resilience cultivation and well-being promotion.

    CONCLUSION: This bibliometric analysis reveals the increasing scholarly interest in psychological interventions for stroke survivors, particularly in resilience and psychological well-being research. The field has evolved from focusing on disease-related factors to systematic intervention research, with a growing emphasis on methodological standardization and individualized interventions. These findings provide significant theoretical and practical implications for improving psychological health services for stroke survivors. Future research should strengthen high-quality empirical studies, refine assessment tools, and innovate intervention strategies to better address the complex psychological needs of stroke survivors and enhance their resilience and psychological well-being, ultimately improving rehabilitation outcomes and quality of life for stroke survivors.

  2. Jing X, Sarker MMR, Gifari MAJ, Maruf MRA, Alam S, Khan F, et al.
    Cell Mol Biol (Noisy-le-grand), 2022 Sep 30;68(9):1-13.
    PMID: 36905282 DOI: 10.14715/cmb/2022.68.9.1
    Piper betle L. leaves are very popular and traditionally used to chew with betel nut in many Asian countries. In this study, P. betle leaves juice (PBJ) was subjected to evaluation for its antihyperlipidemic activity in the high-fat-diet-induced hyperlipidemic rats model. Swiss albino rats were allowed to high-fat- diet for one month, followed by concurrent administration of PBJ for another month. The rats were then sacrificed and collected blood, tissues and organs. Pharmacokinetic, toxicological studies and molecular docking studies were performed using SwissADME, admetSAR and schrodinger suit-2017. Our investigation showed a promising effect of PBJ on body weight, lipid profile, oxidative and antioxidative enzymes, and the principle enzyme responsible for the synthesis of cholesterol. PBJ at 0.5 - 3.0 mL/rat significantly reduced body weight of hyperlipidemic rats compared to control. PBJ at the doses of 1.0, 1.5, 2.0, and 3.0 mL/rat significantly (p<0.05, p<0.01, p<0.001) improved the levels of TC, LDL-c, TG, HDL-c and VLDL-c. Similarly, PBJ doses starting from 1.0 mL/rat to 3.0 mL/rat reduced the oxidative biomarkers AST, ALT, ALP, and creatinine. The level of HMG-CoA was significantly reduced by PBJ doses 1.5, 2, and 3 ml/rat. A number of compounds have been found to have good pharmacokinetic profile and safety and 4-coumaroylquinic acid exerted the best docking score among them. Thus our findings clearly demonstrated the potential lipid-lowering activities of PBJ both in vivo and in silico studies. PBJ can be a good candidate for the development of antihyperlipidemic medication or as an alternative medicine.
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