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  1. Khor, Soo Ping, Rahmad Zakaria, Subramaniam, Sreeramanan
    Trop Life Sci Res, 2016;27(11):139-143.
    MyJurnal
    Throughout the cryopreservation process, plants were exposed to a series of
    abiotic stresses such as desiccation and osmotic pressure due to highly concentrated
    vitrification solution. Abiotic stress stimulates the production of reactive oxygen species
    (ROS) which include hydrogen peroxide, superoxide radicals, and singlet oxygen. Higher
    production of ROS may lead to oxidative stress which contributes to the major injuries in
    cryopreserved explants. Antioxidant enzymes in plant such as ascorbate peroxidase
    (APX) can protect plants from cell damage by scavenging the free radicals. This study was
    determined based on APX enzyme activity of Aranda Broga Blue orchid’s protocorm-like
    bodies (PLBs) in response to PVS2 (Plant Vitrification Solution 2) cryopreservation
    treatments at different stages. PLBs that were precultured at 0.25 M sucrose for 3 days
    were subjected to vitrification cryopreservation method. Results obtained showed that the
    highest APX activity was achieved at PVS2 cryoprotectant treatment prior liquid nitrogen
    (LN) storage. This phenomenon indicating that accumulation of osmotic and dehydrating
    stress throughout the cryopreservation treatment resulted in oxidative burst which in turn
    leads to higher APX activity in order to control the excess production of ROS. To
    conclude, PVS2 treatment was revealed as the most detrimental step throughout
    cryopreservation treatment. Thus, this research also suggested that exogenous
    antioxidant such as ascorbic acid can be added throughout cryopreservation procedure
    especially at PVS2 treatment in the future experiments to aid in regrowth of cryopreserved
    explants by reducing oxidative stress.
  2. Khor SP, Yeow LC, Poobathy R, Zakaria R, Chew BL, Subramaniam S
    Biotechnol Rep (Amst), 2020 Jun;26:e00448.
    PMID: 32368510 DOI: 10.1016/j.btre.2020.e00448
    A droplet-vitrification cryopreservation protocol has been successfully developed for Aranda Broga Blue orchid hybrid using protocorm-like bodies (PLBs). However, maximum growth regeneration percentage was recorded at 5% only based on previous report. Thus, to improve growth recovery of cryopreserved PLBs, cryopreservation stages were supplemented with ascorbic acid, tested at 50, 100 and 150 mg/L. However, results demonstrated that exogenous ascorbic acid was not favorable in regeneration of cryopreserved explants (maximum value of 1.67 % with 50 mg/L ascorbic acid supplementation). Total soluble protein and various antioxidant enzyme activities such as catalase (CAT), superoxide dismutase (SOD) and ascorbate peroxidase (APX) were evaluated after each cryopreservation stages in conjunction with the application of exogenous ascorbic acid. Addition of antioxidant must be carefully evaluated and its application may not guarantee successful growth recovery. RAPD and SCoT molecular analysis confirmed the genetic stability of regenerated cryopreserved PLBs as no polymorphism was detected compared to control PLBs culture.
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