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  1. Fulltext Use of negative pressure individual isolation system for CT scan of patients with suspected COVID-19
    Cheah PK, Krisnan T, Abdul Kadir MH, Steven EM
    Emerg Med J, 2020 Aug;37(8):467.
    PMID: 32546476 DOI: 10.1136/emermed-2020-209851
  2. Fulltext Rare late-presentation congenital diaphragmatic hernia mimicking a tension pneumothorax
    Muien MZA, Jeyaprahasam K, Krisnan T, Ng CY, Teh YG
    Radiol Case Rep, 2021 Sep;16(9):2542-2545.
    PMID: 34276850 DOI: 10.1016/j.radcr.2021.06.024
    Congenital Diaphragmatic Hernia (CDH) is due to a defect in the diaphragm and is usually detected soon after birth. However, in rare cases, asymptomatic CDHs can be missed and present later in life. Late-presentation CDH can be misdiagnosed as tension pneumothorax leading to iatrogenic complications. We report a case of a 10-year-old boy who presented with non-specific symptoms of vomiting and occasional breathlessness, but was subsequently diagnosed as late-presentation CDH. This case highlights the role of imaging in the diagnosis and management of late-presenting CDH. The role of CT imaging as an invaluable tool to further evaluate equivocal radiographic findings in CDH is discussed.
  3. Microstructural Integrity of Peripheral Nerves in Charcot-Marie-Tooth Disease: An MRI Evaluation Study
    Cheah PL, Krisnan T, Wong JHD, Rozalli FI, Fadzli F, Rahmat K, et al.
    J Magn Reson Imaging, 2021 02;53(2):437-444.
    PMID: 32918328 DOI: 10.1002/jmri.27354
    BACKGROUND: Charcot-Marie-Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited.

    PURPOSE: To investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS).

    STUDY TYPE: Prospective case-control.

    SUBJECTS: Nine CMT patients and nine age-matched controls.

    FIELD STRENGTH/SEQUENCE: 3 T T1 -weighted in-/out-of phase spoiled gradient recalled echo (SPGR) and DTI sequences.

    ASSESSMENT: Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in-/out-of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed.

    STATISTICAL TESTS: The Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done.

    RESULTS: There was a significant reduction in FA and increase in RD of both nerves (P 

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