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  1. Disease phenotypic and outcome of very-early onset inflammatory bowel disease in Asian children: an understudied population
    Lee WS, Chew KS, Huang JG, Tanpowpong P, Mercado KSC, Reodica A, et al.
    Front Pediatr, 2025;13:1487253.
    PMID: 40051907 DOI: 10.3389/fped.2025.1487253
    BACKGROUND: There is a paucity of knowledge on disease phenotype and outcome of very early-onset (VEO) inflammatory bowel disease (VEO-IBD) from recently developed and developing countries, including from Southeast Asia. We studied disease phenotype, clinical characteristics, management and outcome of VEO-IBD in South and Southeast Asian children.

    MATERIALS AND METHODS: We extracted data from a multicentre Asian pediatric (onset <18 years) IBD registry. VEO- and later-onset pediatric (LO-p) IBD were defined as onset of disease <6 years and ≥6 years, respectively. We excluded monogenic IBD.

    RESULTS: Of 440 children with IBD cases; 112 (25.5%) were VEO-IBD; Crohn's disease (CD) 36 (32.1%); ulcerative colitis (UC) 68 (60.7%), and IBD-unspecified 7 (7.1%). UC was more common in VEO-IBD while CD more common in LO-pIBD (CD = 68.9% vs. UC = 25.9%; p 

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