Disease phenotypic and outcome of very-early onset inflammatory bowel disease in Asian children: an understudied population

Lee WS 1 , Chew KS 1 , Huang JG 2 , Tanpowpong P 3 , Mercado KSC 4 , Reodica A 5 Show all authors , Logarajah V 6 , Hathagoda KLW 7 , Rajindrajith S 7 , Wong YK 8 , Treepongkaruna S 3 , Aw MM 2

Affiliations 

  • 1 Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
  • 2 KHoo Teck Puat National University Children's Medical Institute, National University Hospital Health System, National University Hospital, Singapore, Singapore
  • 3 Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • 4 Department of Pediatrics, Makati Medical Center, Manila, Philippines
  • 5 Department of Pediatrics, The Medical City, Pasig, Philippines
  • 6 Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore
  • 7 Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
  • 8 Epidemiology, Singapore Clinical Research Institute, Singapore, Singapore
Front Pediatr, 2025;13:1487253.
PMID: 40051907 DOI: 10.3389/fped.2025.1487253

Abstract

BACKGROUND: There is a paucity of knowledge on disease phenotype and outcome of very early-onset (VEO) inflammatory bowel disease (VEO-IBD) from recently developed and developing countries, including from Southeast Asia. We studied disease phenotype, clinical characteristics, management and outcome of VEO-IBD in South and Southeast Asian children.

MATERIALS AND METHODS: We extracted data from a multicentre Asian pediatric (onset <18 years) IBD registry. VEO- and later-onset pediatric (LO-p) IBD were defined as onset of disease <6 years and ≥6 years, respectively. We excluded monogenic IBD.

RESULTS: Of 440 children with IBD cases; 112 (25.5%) were VEO-IBD; Crohn's disease (CD) 36 (32.1%); ulcerative colitis (UC) 68 (60.7%), and IBD-unspecified 7 (7.1%). UC was more common in VEO-IBD while CD more common in LO-pIBD (CD = 68.9% vs. UC = 25.9%; p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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