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  1. Fulltext Moringa oleifera leaf extract loaded hydrogel for diabetic wound healing
    Natarajan, Satheesh Babu, Das, SreemoyKanti, Chandran, Suriyakala Perumal, Aung, Myo Oo, Kanneppady, Sowmya Shar, Entezarian, Maryam, et al.
    Malaysian Journal of Medical Research, 2018;2(2):35-41.
    MyJurnal
    Diabetic wounds (DW) are a chronic, non-healing wound on the feet of diabetic patients that pose a serious challenge to world health. Around 84% of diabetic patients undergo lower leg amputations. Though numerous topical and systemic drugs have been used to heal the DW, these drugs have led to the emergence and subsequent rapid overgrowth of resistant bacterial strains, side effects and toxicity. Many herbal plants have very important role in wound healing because they promote the natural repair mechanisms. Moringa oleifera (MO) is an important medicinal plant which has an impressive range of medicinal uses including antimicrobial, anti-inflammatory, antidiabetic, antioxidant and anticancer activities.Recently few researchers reported that MO extracts have effective wound healing property due to the presence of rich flavonoids and vicenin-2. The objective of the present study was to develop hydrogel formulations loaded with Moringa oleifera leaves extract. The prepared hydrogels were evaluated for physical appearance, rheological behavior, skin irritation and wound-healing power in streptozotocin-induced diabetic male wistar albino rats. Results showed that all hydrogel formulations exhibited good and acceptable physical properties. All the animals tolerated the applied gels and no signs of irritations were noticed during the skin irritation study. The in-vivo wound healing studies showed a time dependent increase in percentage of wound, a contraction which is higher than that produced by the control groups. These contractions were statistically significant (P
  2. Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats
    Lwin OM, Giribabu N, Kilari EK, Salleh N
    J Dermatolog Treat, 2021 Dec;32(8):1039-1048.
    PMID: 32013660 DOI: 10.1080/09546634.2020.1721419
    PURPOSE: This study identifies the potential use of mangiferin gel to promote wound healing in diabetes mellitus (DM).

    MATERIALS AND METHODS: Male rats were rendered diabetes mellitus via intraperitoneal injection of streptozotocin and nicotinamide. Following diabetes development, wound was created at the back of the neck. 1% and 2% mangiferin gel and 1% silver sulphurdiazine (SS) gel (positive control) were applied to the wound for twenty-one (21) days. Fasting blood glucose (FBG) levels were weekly monitored. At the end of the treatment, rats were sacrificed and wound was excised and subjected for histopathological and molecular biological analysis.

    RESULTS: No changes to serum FBG levels was noted throughout the period of mangiferin treatment. Albeit, a significant decrease in the size of the wound with increased in the skin thickness of surrounding the wound were observed. Increased expression and distribution of EGF, FGF, TGF-β, VEGF, PI3K, MMP and Nrf2 and decreased expression and distribution of TNFα and NF-κB p65 were observed in diabetic wound treated with topical mangiferin.

    CONCLUSIONS: Mangiferin has potential to be used as an agent to promote wound healing in diabetic condition.

  3. Strawberry Marks on Lip
    Kanneppady SS, Kanneppady SK, Chaubal T, Bapat R, Pandurangappa R, Oo AM, et al.
    Am J Med, 2019 04;132(4):e538-e539.
    PMID: 30503886 DOI: 10.1016/j.amjmed.2018.11.019
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