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  1. Ab Ghani NS, Emrizal R, Makmur H, Firdaus-Raih M
    Comput Struct Biotechnol J, 2020;18:2931-2944.
    PMID: 33101604 DOI: 10.1016/j.csbj.2020.10.013
    Structures of protein-drug-complexes provide an atomic level profile of drug-target interactions. In this work, the three-dimensional arrangements of amino acid side chains in known drug binding sites (substructures) were used to search for similarly arranged sites in SARS-CoV-2 protein structures in the Protein Data Bank for the potential repositioning of approved compounds. We were able to identify 22 target sites for the repositioning of 16 approved drug compounds as potential therapeutics for COVID-19. Using the same approach, we were also able to investigate the potentially promiscuous binding of the 16 compounds to off-target sites that could be implicated in toxicity and side effects that had not been provided by any previous studies. The investigations of binding properties in disease-related proteins derived from the comparison of amino acid substructure arrangements allows for effective mechanism driven decision making to rank and select only the compounds with the highest potential for success and safety to be prioritized for clinical trials or treatments. The intention of this work is not to explicitly identify candidate compounds but to present how an integrated drug repositioning and potential toxicity pipeline using side chain similarity searching algorithms are of great utility in epidemic scenarios involving novel pathogens. In the case of the COVID-19 pandemic caused by the SARS-CoV-2 virus, we demonstrate that the pipeline can identify candidate compounds quickly and sustainably in combination with associated risk factors derived from the analysis of potential off-target site binding by the compounds to be repurposed.
  2. Dahlan M, Bustami MR, Makmur, Mas'ulah S
    Heliyon, 2021 Jul;7(7):e07541.
    PMID: 34368475 DOI: 10.1016/j.heliyon.2021.e07541
    BACKGROUND: The act of worshipping in mosque is often not only considered to be one of the factors causing the transmission of coronavirus disease 2019 (covid-19), but also a contributing factor to health protocol violations. Against this backdrop, the purpose of this paper is to examine the application of the Islamic principle of ḥifẓ al-nafs (protection of life) in the practice of worshipping at the Nurul Iman mosque as it relates to the prevention of transmission of covid-19.

    METHODS: This research uses a sociology of law perspective to the connection and the dynamics between the adoption of the principle of ḥifẓ al-nafs and the implementation of worship at the Nurul Iman mosque. As a case study, the data collection technique used includes interviews, observation, documentation reviews, and triangulation techniques, while the analysis technique used content analysis techniques.

    RESULTS: The application of the principle of ḥifẓ al-nafs (protection of life) in the practices of worship at the Nurul Iman mosque have proven to be in accordance with health protocols and at the same time all members of the mosque congregation have been free from the transmission of covid-19. From an Islamic needs framework perspective, in the context of Covid-19 pandemic, the application of the ḥifẓ al-nafs principle at this mosque is a considered primary necessity (ḍarūriyyāt) in that it protects life while providing spiritual continuity of collective religious worshipping, hence integrating the community together within a health and sanctity of life paradigm during this challenging time. Equally important, this research also challenges the thesis of the direct linkage between worshipping in mosque and Covid-19 transmission.

    CONCLUSION: the application of the principle of ḥifẓ al-nafs in the practices of worship in mosque has demonstrably shown that the congragants levels of health consciousness has increased and that they have also been kept safe. In essence, the effective contextualization of Islamic principle is able to provide the twin benefits of health and spirituality.

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