Natural polyphenols have gained greater attention for their potent medicinal properties and potential benefits in addressing various health concerns. Resveratrol, a polyphenolic compound known for its therapeutic properties, has shown limitations in bioavailability, which the novel derivative resveratrol surrogate molecule (RSM5) aims to improve. The present study evaluates the oral toxicity and safety profile of a novel resveratrol derivative through acute and subacute assessments. Acute toxicity was assessed following a single oral administration, while subacute toxicity was evaluated after repeated doses over 28 days in BALB/c mice. Various physiological, biochemical, and histopathological parameters were monitored to determine potential adverse effects. The findings indicate that the RSM5 exhibits no significant toxic effects at the tested doses (15, 30, 60 mg/kg), with both acute and subacute studies showing a favourable safety profile. These results suggest that the novel resveratrol derivative may be safe for further pharmacological development, supporting its potential for therapeutic applications.
Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or biological fluids. Due to the growing demand for enhancing current therapies, nanogels have emerged as the next-generation drug delivery system. They effectively address the limitations of conventional drug therapy, such as poor stability, large particle size, and low drug loading efficiency. Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. This article covers several topics, including the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties like biocompatibility, biodegradability, drug loading capacity, particle size, permeability, non-immunological response, and colloidal stability. Additionally, it provides information on nanogel classification, synthesis, drug release mechanisms, and various biological applications. The article also discusses barriers associated with brain targeting and the progress of nanogels as nanocarriers for delivering therapeutic agents to the central nervous system.