Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a bacteria or germ which many people carry in their nose or on their skin and it is resistant to a range of antibiotics including methicillin. The primary mode of transmission of S. aureus is by direct contact usually, skin-to-skin contact, although contact with contaminated objects and surfaces or might also play a role. The risk of infection by antibiotic-resistant organisms is a common problem in a hospital setting. When it comes to caring for the patient with an infectious disease such as MRSA, most nursing students tried to avoid caring for the patient because they fear of getting infected. So, in this regards that it is important to find out the perception of nursing students towards MRSA patients. Methods: This study is a descriptive cross-sectional study design and a structured questionnaire used to evaluate the perception among student nurses regarding care for a patient with MRSA. The population of this study consists only of the nursing student of year 2 and year 3, which is 118 students. A minimum of 60 respondents selected by convenient sampling from this population. Results: Findings showed the respondent’s perception towards MRSA patients that 83.55% (n=55) of the respondent has the feeling of avoiding getting close to MRSA patients. While 16.7% (n=11) did not have the feeling to avoid them. 47% (n=31%) respondents felt refused to do any procedure on MRSA patients. While 53% (n=35) did not feel refuse to do any procedure on MRSA patient. 92.4% (n=61) respondents wear full PPE before caring for patients with MRSA. The other 7.6% (n=5) did not wear full PPE before caring for patients with MRSA. 98.5% (n=65) respondents always follow 5 moments of hand hygiene. While the other 1.5% (n=1) did not always follow 5 moments of hand hygiene. Conclusion: To conclude, even though most of the respondents know about MRSA but some of them did not know that MRSA is curable or not, some confusion about the mode of transmission of MRSA and did not know that they should wear full PPE in caring for the patient with MRSA. Lack of knowledge about MRSA might influence them to ask their friends to do procedures for the patient instead of doing it by themselves. Without good knowledge and skills about how to handle infectious patients, it is difficult for the nursing students to approach the patient with an infectious disease such as MRSA.