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  1. Liew, Pit Sze, Nurulfiza Mat Isa, Omar Abdul Rahman, Aini Ideris, Mohd HAIRBEJO
    MyJurnal
    Infectious bursal disease (IBD), also known as the Gumboro disease, has been a great
    concern for poultry industry worldwide. The first outbreak of IBD due to very virulent (vv) IBD virus
    (IBDV) infection in Malaysia was reported in 1991. The major economic impact of the disease is high
    mortality and poor performance. The virus causes immunosuppression where if the infected chicken
    recovered from the acute disease, they become more susceptible to infections of other pathogens and
    fail to respond to vaccines. Therefore, prevention is important and vaccination has become the
    principal control measure of IBDV infection in chickens. The conventional attenuated live and killed
    vaccines are the most commonly used vaccines. With the advancement of knowledge and technology,
    new generation of genetically-engineered vaccines like viral vector and immune complex vaccines
    have been commercialised. Moreover, hatchery vaccination is becoming a common practise, in
    addition to farm vaccination. Currently, the disease is considerably under controlled with the
    introduction of vaccination. However, occasional field outbreaks are still commonly reported. The
    demand for vaccines that could suit the field situation continues to exist. The endemicity of disease,
    presence of challenge in the farm and maternally derived antibody in chicks are affecting the choice
    vaccine as well as the vaccine development and vaccination strategies. In this review, advances made
    in various vaccines that have been commercialised or under development, and challenges that they
    face, are outlined. Furthermore, how the emergence of vvIBDV affect the progress of vaccine
    development and influence its vaccination strategy are discussed.
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