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  1. Fulltext Cross-sectional network structure of alexithymia, empathy, anxiety, and depression in male inpatients with alcohol use disorder
    Liu Y, Liu H, Mu D, Sui H, Ma Y, Kong X
    Acta Psychol (Amst), 2026 Oct;270:107918.
    PMID: 42810120 DOI: 10.1016/j.actpsy.2026.107918
    BACKGROUND: Alcohol use disorder (AUD) frequently co-occurs with alexithymia, empathy-related difficulties, anxiety, and depression, but their conditional associations remain unclear in male inpatients with AUD.

    METHODS: We analyzed data from 385 male inpatients with AUD treated at a psychiatric specialty hospital in China. Alexithymia, empathy, anxiety, and depression were assessed with the Toronto Alexithymia Scale-20 (TAS-20), the Chinese Interpersonal Reactivity Index (IRI-C), the 14-item Hamilton Anxiety Rating Scale (HAM-A), and the 24-item Hamilton Depression Rating Scale (HAMD-24), respectively. We estimated a Gaussian graphical model and examined one-step expected influence (EI), one-step bridge expected influence (BEI), and bootstrap-based accuracy and stability.

    RESULTS: Difficulty identifying feelings (DIF) had the highest EI and exceeded empathic concern (EC), HAMD-24, and psychic anxiety (PSY) in bootstrap comparisons. Under the primary community assignment, HAMD-24, DIF, and PSY had relatively large BEI point estimates, with no bootstrap-supported pairwise differences among them. Externally oriented thinking (EOT) was negatively associated with perspective taking (PT), whereas personal distress (PD) was positively associated with PSY. For somatic anxiety (SOM), the retained between-community edges with PT and fantasy (FS) were weaker than the within-community edges with PSY and HAMD-24. Correlation stability coefficients for strength, EI, and BEI ranged from 0.595 to 0.673.

    CONCLUSIONS: Conditional associations among alexithymia, empathy, anxiety, and depression varied across nodes in male inpatients with AUD. Under the primary community assignment, HAMD-24, DIF, and PSY had relatively large BEI point estimates, with no bootstrap-supported pairwise differences among them.

  2. Nutrient fluxes across sediment-water interface in Bohai Bay Coastal Zone, China
    Mu D, Yuan D, Feng H, Xing F, Teo FY, Li S
    Mar Pollut Bull, 2017 Jan 30;114(2):705-714.
    PMID: 27802871 DOI: 10.1016/j.marpolbul.2016.10.056
    Sediment cores and overlying water samples were collected at four sites in Tianjin Coastal Zone, Bohai Bay, to investigate nutrient (N, P and Si) exchanges across the sediment-water interface. The exchange fluxes of each nutrient species were estimated based on the porewater profiles and laboratory incubation experiments. The results showed significant differences between the two methods, which implied that molecular diffusion alone was not the dominant process controlling nutrient exchanges at these sites. The impacts of redox conditions and bioturbation on the nutrient fluxes were confirmed by the laboratory incubation experiments. The results from this study showed that the nutrient fluxes measured directly from the incubation experiment were more reliable than that predicted from the porewater profiles. The possible impacts causing variations in the nutrient fluxes include sewage discharge and land reclamation.
  3. Fulltext Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery
    Volak A, LeRoy SG, Natasan JS, Park DJ, Cheah PS, Maus A, et al.
    J Neurooncol, 2018 Sep;139(2):293-305.
    PMID: 29767307 DOI: 10.1007/s11060-018-2889-2
    The malignant primary brain tumor, glioblastoma (GBM) is generally incurable. New approaches are desperately needed. Adeno-associated virus (AAV) vector-mediated delivery of anti-tumor transgenes is a promising strategy, however direct injection leads to focal transgene spread in tumor and rapid tumor division dilutes out the extra-chromosomal AAV genome, limiting duration of transgene expression. Intravenous (IV) injection gives widespread distribution of AAV in normal brain, however poor transgene expression in tumor, and high expression in non-target cells which may lead to ineffective therapy and high toxicity, respectively. Delivery of transgenes encoding secreted, anti-tumor proteins to tumor stromal cells may provide a more stable and localized reservoir of therapy as they are more differentiated than fast-dividing tumor cells. Reactive astrocytes and tumor-associated macrophage/microglia (TAMs) are stromal cells that comprise a large portion of the tumor mass and are associated with tumorigenesis. In mouse models of GBM, we used IV delivery of exosome-associated AAV vectors driving green fluorescent protein expression by specific promoters (NF-κB-responsive promoter and a truncated glial fibrillary acidic protein promoter), to obtain targeted transduction of TAMs and reactive astrocytes, respectively, while avoiding transgene expression in the periphery. We used our approach to express the potent, yet toxic anti-tumor cytokine, interferon beta, in tumor stroma of a mouse model of GBM, and achieved a modest, yet significant enhancement in survival compared to controls. Noninvasive genetic modification of tumor microenvironment represents a promising approach for therapy against cancers. Additionally, the vectors described here may facilitate basic research in the study of tumor stromal cells in situ.
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