MyMedR

Muniandy J, Chan KK, Bakin S

J Gastrointest Surg, 2021 Oct;25(10):2715-2717.

PMID: 33834378 DOI: 10.1007/s11605-021-05002-4

Khor Ee IH, Chor Lip HT, Muniandy J

ANZ J Surg, 2021 Jul 29.

Prone Jack-Knife Transanal Minimally Invasive Surgery: A Safe and Effective Approach for Anterior Low Rectal GI Stromal Tumors

Muniandy J, Huang CW, Ke TW, Chen WT

Dis Colon Rectum, 2024 May 01;67(5):e291.

PMID: 38323637 DOI: 10.1097/DCR.0000000000003078

Cost analysis of utilising wound edge protector in open appendicectomy to prevent surgical site infection

Muniandy J, Azman A, Murugasan V, Alwi RI, Zuhdi Z, Jarmin R, et al.

Ann Med Surg (Lond), 2021 Aug;68:102573.

PMID: 34354831 DOI: 10.1016/j.amsu.2021.102573

Background: The rate of surgical site infection (SSI) differ with variable nature with appendicitis with a global incidence of up to 11%. Several randomised trials describe a significant reduction in incisional SSI using wound edge protectors (WEP), mainly in elective procedures. This study was designed to analyse WEP use in emergency open appendicectomy.

Method: This randomised controlled trial enrolled 200 patients who underwent emergency open appendicectomy. Permuted block randomisation was used to assign subjects to either mechanical retraction or double ring WEP. The primary endpoints were SSI rates and cost analysis between the methods.

Results: The incidence of SSI was similar, n = 7 (7.4%) in the control group and n = 8 (8.4%) in the WEP group, and demonstrates no statistically significant difference (p > 0.05). Cost analysis showed a statistically significant (p

Fulltext Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

Khalilpour S, Behnammanesh G, Suede F, Ezzat MO, Muniandy J, Tabana Y, et al.

Biomedicines, 2018 Apr 23;6(2).

PMID: 29690612 DOI: 10.3390/biomedicines6020048

Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β⁻carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.

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