Pressure ulcer has been recognized as one of the major causes of morbidity, mortality and a burden to healthcare. Our aim is to compare the level of knowledge regarding pressure ulcer prevention among final year nursing students in one of the Health Campus in Kelantan. This is a cross-sectional study aimed to determine and compare the knowledge of pressure ulcer prevention among the nursing students. The total sample for this study is 108 students. The sampling methods used are purposive sampling methods, i.e. the sample was chosen based on the potentially knowledge about the phenomena studied. Self-administered questionnaire is used to measure the characteristic and knowledge level of sample towards pressure ulcer prevention. Data including descriptive statistic and statistical tests was analyzed using the SPSS version 22.0. Finding of this study was significant with p<0.001 (significant at p<0.05). This indicates the significant differences of pressure ulcer knowledge between both programmes. The degree students have higher knowledge than the diploma students. Therefore, it is evident from this study that higher the level of education, the higher is the knowledge regarding pressure ulcer.