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  1. Noor Azliza Wani, A.A., Zar Chi, T., Azian, A.L., Mohamad Fairuz, Y., Teoh, S.L., Taty Anna, K.
    Medicine & Health, 2016;11(2):232-244.
    MyJurnal
    The occurrence of severe lead (Pb) poisoning has risen in certain countries.
    There is increasing evidence that chronic lead exposure disturbs the prooxidant:
    antioxidant balance in the brain tissue and alters brain histology. The present
    study observed the antioxidant effect of tocotrienol-rich fraction (TRF) on brain
    tissues of the experimental rats following lead poisoning. Eighteen (n=18) male
    Sprague-Dawley rats, 6-weeks old, were randomly divided into control (CTRL)
    group and experimental groups; fed with 0.2% w/v lead acetate, as PB2 group;
    and fed with 0.2% w/v lead acetate and daily TRF supplementation (200 mg/kg
    body weight) as PB2T group. The experiment was conducted for 30 days. At the
    end of the study, the brain tissues were harvested and histopathological changes of
    the hippocampal region were observed. Biochemical findings such as brain lead,
    TRF and malondialdehyde (MDA) levels, and erythrocyte superoxide dismutase
    (SOD) activity were determined. It was observed that atypical apoptotic-like and
    disorganized neurons were present in the hippocampal region of the untreated
    PB2 group compared to PB2T group. Biochemical parameters showed a significant
    decrease (p < 0.05) in brain lead level in PB2T compared to PB. Even though no
    significant difference (p > 0.05) was obtained for MDA level, there was a significant
    increase (p < 0.05) in the erythrocyte SOD activity in PB2T compared to PB2 and
    CTRL. Supplementation with TRF improved histopathological changes in the brain
    tissues caused by lead exposure in drinking water by reducing lead accumulation
    in the brain of experimental rats.
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