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  1. Malina Jasamai, Nurul Hanis Samsudin, Norazrina Azmi, Endang Kumolosasi
    Sains Malaysiana, 2018;47:1221-1226.
    Durian or scientifically known as Durio zibethinus is one of the most well-known seasonal fruits in the Southeast Asia
    region. However, its safe consumption in individuals with hypertension is still controversial. This study was conducted
    to investigate the effect of durian on blood pressure of spontaneously hypertensive rat model. Four groups of rats (n=5)
    were fed with either a low dose durian (26 g/kg), a high dose durian (52 g/kg), sugar solution (8 mL/kg) which has
    similar sugar composition in the durian as placebo control, and distilled water as vehicle control (8 mL/kg) for 14 days.
    The durian doses for rats were obtained by converting from human doses. Baseline reading of blood pressure and heart
    rate were recorded before the first oral administration of durian. The blood pressure and heart rate were also measured
    1 h after the durian oral administration on day 1, 3, 7 and 14 of the experiment. In conclusion, durian fruit possessed
    an acute effect on the blood pressure of hypertensive rats but heart rate was unaffected. High dose administration of
    durian led to significant elevation of blood pressure after 1 h of consumption. Meanwhile, low dose of durian (26 g/kg)
    caused an insignificant reduction in systolic and diastolic blood pressure. Tolerance to the durian fruit was observed after
    three to seven days of the oral administration and low dose consumption of durian fruit was safe in the hypertensive rat.
  2. Norazrina Azmi, Loh WT, Siti Suriani Omar, Juriyati Jalil, Aishah Adam
    Sains Malaysiana, 2011;40:1097-1103.
    The aqueous extract of Prismatomeris glabra root has been used traditionally in Malaysia by the aborigines and certain rural Malays for its ergogenic effects, to maintain wellness and to enhance physical stamina. It has also been used as an aphrodisiac for generations in the east coast of Peninsular Malaysia. Previous studies have shown that plants with ergogenic effects may also act as a stimulant and impair cognitive function. Therefore, we seek to investigate the effects of P. glabra on non-spatial memory in male Sprague Dawley rats using object recognition test. Trial rats were injected intraperitoneally with an aqueous extract of P. glabra roots at doses of 50 and 100 mg/kg for the acute (30 min) and subacute (7 days) studies. Scopolamine (0.3 mg/kg) was used as a positive control only in the acute study meanwhile control rats were injected with saline. The locomotor activity of rats was also determined in the same test. We demonstrated that groups treated with 50 and 100 mg/kg of the extract lost their ability to discriminate the novel from familiar object in choice phase and did not alter the locomotor activity in both studies. Our results also indicated that the deficits in non-spatial working memory occured at these doses were not due to impaired locomotor activity.
  3. Manali Haniti Mohd-Zahid, Juriyati Jalil, Norazrina Azmi, Kok Meng Chan
    Sains Malaysiana, 2018;47:2129-2139.
    Neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease are characterized by the progressive loss of
    neurons. One of the contributing factors for these diseases is oxidative stress, characterized by the imbalance of free
    radicals production and antioxidant defense mechanisms. In the present study, the neuroprotective effects of Ocimum
    basilicum var. thyrsiflora against hydrogen peroxide (H2
    O2
    )-induced oxidative stress in SK-N-SH neuroblastoma cells
    were evaluated. The exposure of SK-N-SH cells to 50 µM H2
    O2
    for 24 h induced cytotoxicity and apoptosis as measured
    by cell viability and flow cytometry, respectively. Pretreatment with ethyl acetate (ObEA) fraction at 3.1-25 µg/mL showed
    the highest protection against H2
    O2
    -induced cell death compared to other fractions and crude extract by increasing cell
    viability and reducing apoptosis. The evaluation of antioxidant capacity via 1, 1-diphenyl-2-picrylahydrazyl (DPPH)
    and ferric reducing/antioxidant power (FRAP) assays showed ObEA possessed the highest antioxidative properties. The
    intracellular reactive oxygen species (ROS) production of H2
    O2
    in untreated cells increased by 2.39-fold compared to the
    control and was significantly attenuated by the 2 h pre-treatment of O. basilicum (p<0.05). The reduction in intracellular
    superoxide dismutase (SOD) induced by H2
    O2
    was also abrogated by the pretreatment of O. basilicum. These findings
    suggested that O. basilicum is potentially neuroprotective against oxidative damage in neuronal cells by scavenging free
    radicals, restoring SOD activities and eventually prevent cell death.
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