Displaying all 3 publications

Abstract:
Sort:
  1. Fulltext Gene expression analysis of the concomitant existence of lymphovascular and perineural invasion in colorectal cancer
    Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal
    Asia-Pacific Journal of Molecular Medicine, 2018;8(2):1-13.
    MyJurnal
    The invasion of cancer cells into the peritumoral, lymph node and perineural system could be detrimental
    on cancer patients. In colorectal cancer (CRC) patients, the presence of lymphovascular (LVI) and/or
    perineural (PNI) invasion could significantly influence on the survival rates, treatment options and
    recurrence tendencies. To date, no study has analyzed the molecular profile of the concomitant existence of
    LVI and PNI in CRC. Here, we reanalyzed The Cancer Genome Atlas (TCGA) CRC datasets and focused
    on cases where the information regarding LVI and PNI are available (n=176). We performed differential
    gene expression, methylation and microRNA analysis by comparing the groups having both or either LVI
    and PNI with the control group (LVI negative and PNI negative). Although there was no significant
    difference in the methylation and miRNA profiles, we identified a number of differentially expressed genes
    (DEGs). The comparison between the LVI+PNI+ and LVI-PNI- groups revealed key DEGs including
    SFTA2, PHACTR3, CRABP2, ODZ3, GRP, HAP1, CSDC2, TMEM59L and HDAC9. Meanwhile, in the
    LVI-PNI+ vs LVI-PNI- group, some of the DEGs found were PTPRR, EFNA2, FGF20, IGFL4, METRN
    and IGFBPL1. We believe that this study could be beneficial and add value to further understand the
    complex molecular profiles of CRC.
  2. Fulltext miRNAS as potential biomarkers in head and neck squamous cell carcinoma diagnostics
    Cheah Yoke Kqueen, Yaghma Masood, Nurul Syakima Ab Mutalib, Sethu Thakachy Subha, Norhafizah Mohtarrudin
    Malaysian Journal of Medicine and Health Sciences, 2019;15(108):9-9.
    MyJurnal
    MicroRNAs (miRNAs) are small noncoding RNAs that involved in various normal and cancer-related cellular pro-cesses. Studies on expression profiling of miRNAs have been performed and the data showed that some miRNAs are up-regulated or down-regulated in cancer. miRNAs play a crucial role in HNSCC development, metastasis, prognosis and survival rate. Several studies have been conducted previously to investigate that use of miRNAs as the biomark-ers in disease diagnostic/prognostic and potential therapeutic targets management that may improve the outcomes of HNSCC. Our previous study revealed that upregulation of oncogenic miRNAs including hsa-miR-181a-2*, hsa-miR-29b-1*, hsa-miR-181a, hsa-miR-181b, hsa-miR-744, hsa-miR-1271 and hsa-miR-221* were able to distinguish HNSCC from normal samples. These miRNAs may contribute in a simple profiling strategy to identify individuals at higher risk of developing head and neck cancers, thus helping in the elucidation of the molecular mechanisms involved in head and neck cancer pathogenesis.
  3. miR-205 in situ expression and localization in head and neck tumors - a tissue array study
    Nurul-Syakima AM, Learn-Han L, Yoke-Kqueen C
    Asian Pac J Cancer Prev, 2014;15(21):9071-5.
    PMID: 25422181
    BACKGROUND: microRNAs are small non-coding RNA that control gene expression by mRNA degradation or translational inhibition. These molecules are known to play essential roles in many biological and physiological processes. miR-205 may be differentially expressed in head and neck cancers; however, there are conflicting data and localization of expression has yet to be determined.

    MATERIALS AND METHODS: miR-205 expression was investigated in 48 cases of inflammatory, benign and malignant tumor tissue array of the neck, oronasopharynx, larynx and salivary glands by Locked Nucleic Acid in situ hybridization (LNA-ISH) technology.

    RESULTS: miR-205 expression was significantly differentially expressed across all of the inflammatory, benign and malignant tumor tissues of the neck. A significant increase in miR-205 staining intensity (p<0.05) was observed from inflammation to benign and malignant tumors in head and neck tissue array, suggesting that miR-205 could be a biomarker to differentiate between cancer and non-cancer tissues.

    CONCLUSIONS: LNA-ISH revealed that miR-205 exhibited significant differential cytoplasmic and nuclear staining among inflammation, benign and malignant tumors of head and neck. miR-205 was not only exclusively expressed in squamous epithelial malignancy. This study offers information and a basis for a comprehensive study of the role of miR-205 that may be useful as a biomarker and/or therapeutic target in head and neck tumors.

Related Terms
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links