MyMedR

Fulltext The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus

Chan KH, Peiris JS, Lam SY, Poon LL, Yuen KY, Seto WH

Adv Virol, 2011;2011:734690.

PMID: 22312351 DOI: 10.1155/2011/734690

The main route of transmission of SARS CoV infection is presumed to be respiratory droplets. However the virus is also detectable in other body fluids and excreta. The stability of the virus at different temperatures and relative humidity on smooth surfaces were studied. The dried virus on smooth surfaces retained its viability for over 5 days at temperatures of 22-25°C and relative humidity of 40-50%, that is, typical air-conditioned environments. However, virus viability was rapidly lost (>3 log(10)) at higher temperatures and higher relative humidity (e.g., 38°C, and relative humidity of >95%). The better stability of SARS coronavirus at low temperature and low humidity environment may facilitate its transmission in community in subtropical area (such as Hong Kong) during the spring and in air-conditioned environments. It may also explain why some Asian countries in tropical area (such as Malaysia, Indonesia or Thailand) with high temperature and high relative humidity environment did not have major community outbreaks of SARS.

Fulltext Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial

Syn NL, Wong AL, Lee SC, Teoh HL, Yip JWL, Seet RC, et al.

BMC Med, 2018 07 10;16(1):104.

PMID: 29986700 DOI: 10.1186/s12916-018-1093-8

BACKGROUND: Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved.

METHODS: An open-label, non-inferiority, 1:1 randomized trial was conducted at three academic hospitals in South East Asia, involving 322 ethnically diverse patients newly indicated for warfarin (NCT00700895). Clinical follow-up was 90 days. The primary efficacy measure was the number of dose titrations within the first 2 weeks of therapy, with a mean non-inferiority margin of 0.5 over the first 14 days of therapy.

RESULTS: Among 322 randomized patients, 269 were evaluable for the primary endpoint. Compared with traditional dosing, the genotype-guided group required fewer dose titrations during the first 2 weeks (1.77 vs. 2.93, difference -1.16, 90% CI -1.48 to -0.84, P

Fulltext Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19

Calisher C, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, et al.

Lancet, 2020 03 07;395(10226):e42-e43.

PMID: 32087122 DOI: 10.1016/S0140-6736(20)30418-9

Fulltext Science, not speculation, is essential to determine how SARS-CoV-2 reached humans

Calisher CH, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, et al.

Lancet, 2021 Jul 17;398(10296):209-211.

PMID: 34237296 DOI: 10.1016/S0140-6736(21)01419-7

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