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  1. Rabiatul Adawiyah Umar, Nurul 'Adani Sanusi, Mohd Nizam Zahary, Mohd Adzim Khalili Rohin, Salwani Ismail
    MyJurnal
    Piper betel is a member of the family Piperaceae, commonly known as Sirih (Malaysia and
    Indonesia), Paan (India and Bangladesh), Betel (English) and Phlu (Thailand). It is widely found and
    grown in India, Sri Lanka, Malaysia, Indonesia, Philippines, other Southeast Asian and East African
    countries. Piper betel is widely used throughout the world even in modern days due to its known
    medicinal properties. Betel plant contains various biologically active compounds, which are
    responsible for its numerous pharmacological actions. The therapeutic profile reveals Piper betel to
    have a high potential for treating many diseases and conditions such as chronic renal disease,
    atherosclerosis, and diabetes mellitus. Further studies of betel plant are recommended to focus on
    the variety of metabolic activities in human, thus, improving its usage medically that will be beneficial
    to humanity.
  2. Ridzuan, P.M., Nasir Mohamad, Salwani Ismail, Nor Iza A. Rahman, Sanusi, N.A., Rabiatul Adawiyah Umar, et al.
    MyJurnal
    Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on
    human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime.
    Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential and
    its mechanism of action has not been studied yet. The objective of this preliminary study to determine the
    antifungal properties of HC against T. rubrum using transmission electron microscope (TEM) on gross and
    ultrastructure of T. rubrum hypha. T. rubrum was treated with HC and miconazole (MI) at concentrations of
    1.25, 2.5, 5 and 10 mg/mL for 1, 3, 5 and 7 days continuously. Generally, fungi structures became more
    severely damaged at increasing treatment duration. Microscopically, the fungi’s cell wall treated with HC
    showed a rough surface, shrinkage and demolition similar to the MI treated group. The fungi organelles were
    also demolished and disorganized. This study revealed that HC has the ability to inhibit T. rubrum growth
    and has potential to be an antifungal agent for skin infections.
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