MyMedR

Displaying all 3 publications

Abstract:

Sort:

A Biomechanical Study of Calcaneal Tuberosity Avulsion Fracture: A Comparison Between Three-Screw Versus Two-Screw Fixation Strength

Wan KL, Raghavan S, Chua Y, Shanmugam R, Ibrahim MI

Cureus, 2024 Mar;16(3):e56967.
PMID: 38665725 DOI: 10.7759/cureus.56967

A calcaneal tuberosity avulsion fracture constitutes a sub-group of calcaneal fractures and it poses a high risk of soft tissue compromise, necessitating urgent reduction and fixation. This fracture was commonly treated with screw fixation, and fixation failure associated with this method has been reported in the literature. In light of this, we tested and compared the strength of two-screw (2S) versus three-screw (3S) fixations, where the third screw was fixed from the posterior calcaneal tuberosity towards the anterior process in addition to the two parallel screws. Synthetic calcaneum models were tested with an Instron machine to measure the maximum tensile load and stiffness. The mean maximum tensile loads for 3S and 2S were 455.8 N (SD = 47.4) and 341.0 N (SD = 30.9), respectively, and the difference was statistically significant. The mean stiffnesses for 3S and 2S were 29.2 N/mm (SD = 1.8) and 29.7 N/mm (SD = 2.0), but this difference did not reach statistical significance. Based on our findings, the added third screw increased the pull-out strength and can be inserted percutaneously to minimize soft tissue compromise.
Two different regimens of outpatient Foley catheter induction of labor in nulliparas: A randomized trial

Hong J, Raghavan S, Siti Nordiana A, Saaid R, Vallikkannu N, Tan PC

Int J Gynaecol Obstet, 2024 Apr;165(1):265-274.
PMID: 37846154 DOI: 10.1002/ijgo.15199

OBJECTIVES: To evaluate expectant compared to immediate return to hospital upon outpatient Foley catheter expulsion predicated on maternal satisfaction and amniotomy-titrated oxytocin infusion to delivery interval.
METHODS: This randomized trial was conducted in a tertiary university hospital in Malaysia from September 2020 to February 2022. A total of 330 nulliparous women at term with unripe cervices (Bishop score ≤5), singleton viable fetus in cephalic presentation, reassuring preinduction fetal heart rate tracing and intact membranes who underwent planned outpatient Foley catheter induction of labor (IOL) were included. Women were randomized to expectant or immediate return to hospital if the Foley was spontaneously expelled at home before their scheduled hospital admission the following day. Primary outcomes were amniotomy-titrated oxytocin infusion to delivery interval and maternal satisfaction on the induction process (assessed by 0-10 visual numerical rating scale [VNRS]).
RESULTS: Amniotomy-titrated oxytocin infusion to delivery interval was 8.7 ± 4.1 versus 8.9 ± 3.9 h, P = 0.605 (mean difference - 0.228 95% CI: -1.1 to +0.6 h) and maternal satisfaction VNRS score was median (interquartile range) 8 (7-9) versus 8 (7-9), P = 0.782. Early return to hospital rates were 37/165 (22.4%) versus 72/165 (43.6%), RR 0.51 (95% CI: 0.37-0.72), P ≤ 0.001, Cesarean delivery rates were 80/165 (48.5%) versus 80/165 (48.5%), RR 1.00 (95% CI: 0.80-1.25), P = 1.00 and duration of hospital stay was 54.4 ± 22.9 versus 56.7 ± 22.8 h, P = 0.364 for the expectant versus immediate return groups respectively.
CONCLUSION: In outpatient Foley catheter IOL, expectant compared to immediate return to hospital following Foley dislodgement results in similarly high maternal satisfaction. The amniotomy-titrated oxytocin to delivery duration is non-inferior with expectant management.
Fulltext Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Tobias DK, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D, et al.

Nat Med, 2023 Oct;29(10):2438-2457.
PMID: 37794253 DOI: 10.1038/s41591-023-02502-5

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.

Filters

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links