Realizing the huge potential of e-learning in casemix education and since there was no e-learning program on casemix and clinical coding available globally. International Centre for Case-mix and Clinical Coding (ITCC) proposed to establish a universal case-mix education programs through providing an e-learning program (ELP) for case-mix and clinical coding and evaluate its success. The aim of this study is to describe the process of development of e-learning program for casemix system and clinical coding. The introduction of course about casemix and clinical coding was redesigned for elearning program by applying ADDIE model (refer to Analysis, Design, Development, Implementation, and Evaluation).A total number of 57 learners attended to the course from around the world (40 different countries). The mean age of subjects was 34.70±8.66 years. Regarding profession, the largest percentiles (40.4%) of e-learners were belonging to academic sector and healthcare sector. All of the participants felt satisfied or very satisfied with the program. There was a significant difference between pre-test and post-test for e-learners knowledge score at the 0.05 alpha levels. The findings of the evaluation of the case-mix e-learning program indicated that e-learners found the educational performances of the case-mix online program to be satisfactory. With the advent of modern computer networking systems, organizations can employ these systems to enhance learning and performance improvement of case mix system.