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Fulltext Bis(μ-cyclo-hexane-1,3-dicarboxyl-ato)-κO:O,O;κO,O:O-bis-[aqua-(1,10-phenanthroline-κN,N')zinc(II)]

Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 10):m1178.

PMID: 21577713 DOI: 10.1107/S1600536809035144

The cyclo-hexane-1,3-dicarboxyl-ate dianion in the dinuclear centrosymmetric title compound, [Zn(2)(C(8)H(10)O(4))(2)(C(12)H(8)N(2))(2)(H(2)O)(2)], has a chair conformation with both carboxyl-ate groups in equatorial positions. One carboxyl-ate group chelates a Zn(II) atom, whereas the other binds through one O atom only to confer a six-coordinate status to the N-heterocycle-chelated water-coordinated Zn(II) atom. Adjacent dinuclear mol-ecules are linked by O-H⋯O hydrogen bonds into a linear chain.

Fulltext Poly[(μ(2)-4,4'-bipyridine-κN:N')bis-(μ(4)-cyclo-hexane-1,3-dicarboxyl-ato-κO:O':O'':O''')dizinc(II)]

Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 10):m1179.

PMID: 21577714 DOI: 10.1107/S1600536809035168

The cyclo-hexane-1,3-dicarboxyl-ate dianion in the title three-dimensional coordination polymer, [Zn(2)(C(8)H(10)O(4))(2)(C(10)H(8)N(2))](n), has one carboxyl-ate group in an equatorial position and the other in an axial position of the cyclo-hexane ring, which adopts a chair conformation. The carboxyl-ate groups function as bridges to two adjacent Zn(II) atoms, generating a layer motif. Adjacent layers are linked through the 4,4'-bipyridine N-heterocycle, forming a three-dimensional network; the geometry of Zn(II) is square-pyramidal with the N atom of the N-heterocycle occupying the apical position. The N-heterocycle lies about a center of inversion and is disordered in a 1:1 ratio with respect to the C atoms bearing H atoms.

Fulltext 4'-Fluoro-2'-hydroxy-acetophenone

Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):o916.

PMID: 21202398 DOI: 10.1107/S1600536808011173

The title compound, C(8)H(7)FO(2), crystallizes as discrete mol-ecules, the conformation of which may be influenced by an intra-molecular hydr-oxy-carbonyl O-H⋯O hydrogen bond.

Fulltext Low-temperature redetermination of trans-cyclo-hexane-1,2-dicarboxylic acid

Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 6):o992.

PMID: 21202717 DOI: 10.1107/S1600536808012592

The mol-ecule of the title compound, C(8)H(12)O(4), lies on a twofold rotation axis that passes through the mid-points of two opposite C-C bonds of the ring. Carboxyl groups of adjacent mol-ecules are linked by pairs of hydrogen bonds around a centre of inversion; this inter-action gives rise to a chain that runs along [101].

Fulltext Bis[1,5-bis-(1H-indol-3-ylmethyl-ene)thio-carbazonato-κN,S]nickel(II) dimethyl sulfoxide disolvate

Rizal MR, Ali HM, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 6):m755.

PMID: 21202448 DOI: 10.1107/S1600536808011975

The Ni atom in the crystal structure of the centrosymmetric title compound, [Ni(C(19)H(15)N(6)S)(2)]·2C(2)H(6)OS, is N,S-chelated by the deprotonated Schiff bases in a square-planar geometry. The -CH=N-N=C(S)-NH-N=CH- frament is planar. The two indolyl -NH (donor) sites inter-act with dimethyl sulfoxide mol-ecules to furnish a layer motif.

Fulltext Low-temperature redetermination of 3,4,5,6-tetra-hydro-pyrimidin-2(1H)-one

Rizal MR, Azizul I, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):o914.

PMID: 21202396 DOI: 10.1107/S160053680801115X

The low-temperature structure of the title compound, C(4)H(8)N(2)O, is ordered, whereas the central methyl-ene groups is disordered in the reported room-temperature structure. The molecule lies across a mirror plane; adjacent mol-ecules are linked by an N-H⋯O hydrogen bond into a chain.

Fulltext 5-Bromo-1H-indole-3-carbaldehyde thio-semicarbazone

Rizal MR, Ali HM, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):o918.

PMID: 21202400 DOI: 10.1107/S160053680801101X

In the essentially planar title mol-ecule, C(10)H(9)BrN(4)S, the C=N double bond is in a trans configuration. In the crystal structure, the S atom acts as a hydrogen-bond acceptor for the aromatic NH, aliphatic NH and terminal NH(2) groups of three symmetry-related mol-ecules, forming a weak hydrogen-bonded layer structure.

Fulltext 4-Hydr-oxy-3-nitro-benzaldehyde

Rizal MR, Azizul I, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):o915.

PMID: 21202397 DOI: 10.1107/S1600536808011148

The hydroxyl group in each of the two independent mol-ecules of the title compound, C(7)H(5)NO(4), participates in two O-H⋯O hydrogen bonds, viz. one intra-molecular bond to the nitro group and one inter-molecular bond to the aldehyde group of the same mol-ecule in the next unit, resulting in a linear chain structure. The dihedral angle between the aromatic ring and the nitro group is 10.9 (3)° in one mol-ecule and 9.9 (2)° in the other.

Fulltext 1H-Indole-3-carbaldehyde azine

Rizal MR, Ali HM, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 3):o555.

PMID: 21201898 DOI: 10.1107/S1600536808003164

The molecule of the title compound, C(18)H(14)N(4), lies on a center of inversion such that there is one half-mol-ecule in the asymmetric unit. The N-N single bond adopts a trans configuration and the indole fused-ring system is nearly coplanar with the -CH=N-N=CH- fragment [dihedral angle = 9.8 (2)°]. Adjacent mol-ecules are linked by indole-azine N-H⋯N hydrogen bonds into a layer motif.

Fulltext trans-Bis(1H-indole-3-carbaldehyde thio-semicarbazonato-κN,S)nickel(II)

Rizal MR, Ali HM, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 6):m824.

PMID: 21202507 DOI: 10.1107/S1600536808014293

The Ni atom in the centrosymmetric title compound, [Ni(C(10)H(9)N(4)S)(2)], is N,S-chelated by the deprotonated Schiff bases in a square-planar geometry. The -CH=N-N=C(S)-NH(2) frament is planar. Adjacent mol-ecules are linked by hydrogen bonds between the indolyl -NH (donor) site and the double-bond =N- (acceptor) site of an adjacent mol-ecule, forming a layer motif.

Fulltext Bis{2-[2-(1H-indol-3-yl)ethyl-imino-meth-yl]phenolato-κN,O}nickel(II) N,N-dimethyl-formamide disolvate

Ali HM, Mohamed Mustafa MI, Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 6):m787.

PMID: 21202476 DOI: 10.1107/S1600536808012968

The Ni atom in the title compound, [Ni(C(17)H(15)N(2)O)(2)]·2C(3)H(7)NO, lies on a twofold rotation axis. It is N,O-chelated by the deprotonated Schiff base 2-[2-(1H-indol-3-yl)ethyl-imino-meth-yl]phenolate ligand in a square-planar coordination environment. The mol-ecule is linked to a solvent mol-ecule by an indole-dimethyl-formamide N-H⋯O hydrogen bond.

Fulltext 2-[2-(1H-indol-3-yl)ethyl-iminiomethyl]-4-nitro-phenolate

Ali HM, Mohamed Mustafa MI, Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):o913.

PMID: 21202395 DOI: 10.1107/S1600536808011185

The title Schiff base, C(17)H(15)N(3)O(3), exists in the zwitterionic form with the phenol H atom transferred to the imine group. Adjacent zwitterions are linked into a linear chain running along the a axis by an indole-hydr-oxy N-H⋯O hydrogen bond [3.100 (2) Å].

Fulltext N'-(5-Fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl-idene)benzene-sulfono-hydrazide

Ali HM, Laila M, Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):o921.

PMID: 21202402 DOI: 10.1107/S1600536808011136

The mol-ecule of the title compound, C(14)H(10)FN(3)O(3)S, consists of an indole unit and a phenylsulfonyl unit that are disposed in an approximately trans orientation relative to the N-N single bond. Two mol-ecules are arranged about a center of inversion, forming a hydrazide-carbonyl N-H⋯O hydrogen-bonded dimer; the dimers are linked by an indole-sulfonyl N-H⋯O hydrogen bond into a ribbon.

Fulltext N'-(2,5-Dihydroxy-benzyl-idene)benzene-sulfonohydrazide

Ali HM, Yusnita J, Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 2):o522.

PMID: 21201541 DOI: 10.1107/S1600536808002225

In the title compound, C(13)H(12)N(2)O(4)S, the dihedral angle between the two aromatic rings is 89.5 (1)°. In the crystal structure, mol-ecules are linked by O-H⋯O(hydr-oxy) and N-H⋯O(sulfon-yl) hydrogen bonds, forming a ribbon that propagates along the b axis; there is also an intra-molecular O-H⋯N hydrogen bond.

Fulltext Bis{4-chloro-2-[2-(1H-indol-3-yl)ethyl-imino-meth-yl]phenolato-κN,O}zinc(II)

Ali HM, Mohamed Mustafa MI, Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 2):m421.

PMID: 21201365 DOI: 10.1107/S1600536808002213

The Zn atom in the title compound, [Zn(C(17)H(14)ClN(2)O)(2)], is N,O-chelated by two deprotonated Schiff base monoanionic ligands in a tetra-hedral coordination geometry. The Zn atom lies on a special position of site symmetry 2.

Fulltext Dichloridobis(2-{1-[2-(1H-indol-3-yl)ethyl-iminio]eth-yl}phenolate-κO)zinc(II)-2-{1-[2-(1H-indol-3-yl)ethyl-iminio]eth-yl}phenolate (1/2)

Ali HM, Mohamed Mustafa MI, Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):m718-9.

PMID: 21202245 DOI: 10.1107/S1600536808011161

In the mononuclear complex mol-ecule of the title compond, [ZnCl(2)(C(18)H(18)N(2)O)(2)]·2C(18)H(18)N(2)O, the Zn atom, which lies on a twofold rotation axis, is coordinated by phenolate O atoms in a tetra-hedral coordination geometry. The coordinated Schiff base uses its indole NH donor site to form a hydrogen bond to the negatively charged phenolate O atom of the uncoordinated zwitterionic Schiff base. There is an intra-molecular N-H⋯O hydrogen bond in the coordinated and uncoordinated Schiff bases. The indole NH site of the uncoordinated Schiff base does not engage in a hydrogen-bond inter-action. The CH(2)-CH(2) group in the uncoordinated Schiff base is disordered equally over two positions.

Fulltext Gender Differences on Methadone Maintenance Treatment Outcome among Patients with Opioid use Disorder: A Systematic Review

Mohemmad Rizal MR, Hayat Khan A, Noor Harun S, Saleh Z

J Pharm Bioallied Sci, 2020 Nov;12(Suppl 2):S657-S662.

PMID: 33828356 DOI: 10.4103/jpbs.JPBS_253_19

Objectives: The objective of this study was to review the significant differences of MMT outcomes related to drug use behavior, health status, and social behavioral functioning between genders.

Materials and Methods: A search of publication was conducted in PubMed/MEDLINE, Embase, CINAHL, PsycINFO, and Scopus database. Two reviewers independently screened the titles, abstracts, and keyword use for the search. Inclusion of studies was based on randomized controlled trials (RCTs) or observational studies that report the difference of opioid addiction treatment outcomes between genders. Any conflict between the two reviewers was resolved through discussion and consensus. The systematic review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO with a registration number CRD42019116261.

Results: A total of 25 studies were evaluated as part of qualitative synthesis. The review resulted in three main themes, which are (1) improving well-being and methadone-related outcome (five subthemes), (2) impact on social and behavioral (four subthemes), and (3) illicit drug use pattern-related behavior (four subthemes).

Conclusion: This review will highlight how men and women differ in methadone treatment outcomes for further application and improvement in the clinical setting.

Fulltext 1-(2-Hydr-oxy-5-methyl-phen-yl)ethanone [(1H-indol-3--yl)acet-yl]hydrazone

Ali HM, Zuraini K, Wan Jeffrey B, Rizal MR, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 5):o912.

PMID: 21202394 DOI: 10.1107/S1600536808011124

The indolyl -NH group of the title Schiff base, C(19)H(19)N(3)O(2), forms a hydrogen bond to the -OH group of an inversion-related mol-ecule, resulting in a hydrogen-bonded dimer; adjacent dimers are further linked through an inter-dimer N-H⋯O hydrogen bond involving the -C(=O)-NH-N=fragment to form a linear ribbon that runs along the a axis.

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