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Fulltext Anti-Candida activity of Quercus infectoria gall extracts against Candida species

Baharuddin NS, Abdullah H, Abdul Wahab WN

J Pharm Bioallied Sci, 2015 Jan-Mar;7(1):15-20.
PMID: 25709331 DOI: 10.4103/0975-7406.148742

Galls of Quercus infectoria have been traditionally used to treat common ailments, including yeast infections caused by Candida species.
Fulltext Veterinary drug delivery

McDowell A, Rathbone MJ

J Pharm Bioallied Sci, 2014 Jan;6(1):1.
PMID: 24459396 DOI: 10.4103/0975-7406.124299
Fulltext Adverse drug reactions reporting : Knowledge and opinion of general public in Penang, Malaysia

Elkalmi R, Hassali MA, Al-Lela OQ, Jawad Awadh AI, Al-Shami AK, Jamshed SQ

J Pharm Bioallied Sci, 2013 Jul;5(3):224-8.
PMID: 24082699 DOI: 10.4103/0975-7406.116824

The objective of this study was to explore the knowledge of the general population towards ADR and their reporting system.
Fulltext Dissolution behavior of β-cyclodextrin molecular inclusion complexes of aceclofenac

Dua K, Pabreja K, Ramana MV, Lather V

J Pharm Bioallied Sci, 2011 Jul;3(3):417-25.
PMID: 21966164 DOI: 10.4103/0975-7406.84457

The objective of the present investigation was to study the effect of β-cyclodextrin (β-CD) on the in vitro dissolution of aceclofenac (AF) from molecular inclusion complexes. Aceclofenac molecular inclusion complexes in 1:1 and 1:2 M ratio were prepared using a kneading method. The in vitro dissolution of pure drug, physical mixtures, and cyclodextrin inclusion complexes was carried out. Molecular inclusion complexes of AF with β-CD showed a considerable increase in the dissolution rate in comparison with the physical mixture and pure drug in 0.1 N HCl, pH 1.2, and phosphate buffer, pH 7.4. Inclusion complexes with a 1:2 M ratio showed the maximum dissolution rate in comparison to other ratios. Fourier transform infrared spectroscopy and differential scanning calorimetry studies indicated no interaction between AF and β-CD in complexes in solid state. Molecular modeling results indicated the relative energetic stability of the β-CD dimer-AF complex as compared to β-CD monomer-AF. Dissolution enhancement was attributed to the formation of water soluble inclusion complexes with β-CD. The in vitro release from all the formulations was best described by first-order kinetics (R(2) = 0.9826 and 0.9938 in 0.1 N HCl and phosphate buffer, respectively) followed by the Higuchi release model (R(2) = 0.9542 and 0.9686 in 0.1 N HCl and phosphate buffer, respectively). In conclusion, the dissolution of AF can be enhanced by the use of a hydrophilic carrier like β-CD.
Fulltext Attitude of doctors towards physical characteristics of solid oral dosage forms

Hasamnis AA, Patil SS, Mohanty BK, Thu K, Kumar A

J Pharm Bioallied Sci, 2010 Apr;2(2):151.
PMID: 21814452 DOI: 10.4103/0975-7406.66998
Fulltext Erosive potential of commonly used beverages, medicated syrup, and their effects on dental enamel with and without restoration: An in vitro study

Trivedi K, Bhaskar V, Ganesh M, Venkataraghavan K, Choudhary P, Shah S, et al.

J Pharm Bioallied Sci, 2015 Aug;7(Suppl 2):S474-80.
PMID: 26538901 DOI: 10.4103/0975-7406.163508

AIM: This study evaluates erosive potential of commonly used beverages, medicated syrup, and their effects on dental enamel with and without restoration in vitro.
MATERIALS AND METHODS: Test medias used in this study included carbonated beverage, noncarbonated beverage, high-energy sports drink medicated cough syrup, distilled water as the control. A total of 110 previously extracted human premolar teeth were selected for the study. Teeth were randomly divided into two groups. Test specimens were randomly distributed to five beverages groups and comprised 12 specimens per group. Surface roughness (profilometer) readings were performed at baseline and again, following immersion for 14 days (24 h/day). Microleakage was evaluated. The results obtained were analyzed for statistical significance using SPSS-PC package using the multiple factor ANOVA at a significance level of P < 0.05. Paired t-test, Friedman test ranks, and Wilcoxon signed ranks test.
RESULTS: For surface roughness high-energy sports drink and noncarbonated beverage showed the highly significant difference with P values of 0.000 and 0.000, respectively compared to other test media. For microleakage high-energy sports drink had significant difference in comparison to noncarbonated beverage (P = 0.002), medicated syrup (P = 0.000), and distilled water (P = 0.000).
CONCLUSION: High-energy sports drink showed highest surface roughness value and microleakage score among all test media and thus greater erosive potential to enamel while medicated syrup showed least surface roughness value and microleakage among all test media.
Fulltext Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

Sarangarajan R, Vaishnavi Vedam VK, Sivadas G, Sarangarajan A, Meera S

J Pharm Bioallied Sci, 2015 Aug;7(Suppl 2):S420-3.
PMID: 26538890 DOI: 10.4103/0975-7406.163474

Oral ulcers are a common symptom in clinical practice. Among various causative factors, different types of ulcers in oral cavity exist. Among this, traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) appears to be quite neglected by the clinicians due to the limited knowledge and awareness. On reviewing with a detailed approach to titles and abstracts of articles eliminating duplicates, 40 relevant articles were considered. Randomized studies, review articles, case reports and abstracts were included while conference papers and posters were excluded. Of importance, TUGSE cases been reported only to a minimal extent in the literature. Lack of its awareness tends to lead clinicians to a misconception of cancer. Thus, this particular lesion needs to be differentiated from other malignant lesions to provide a proper mode of treatment. The present article reviews various aspects of the TUGSE with emphasis on the clinical manifestation, pathogenesis, histological, and immunohistochemical study. This study provides the clinician contemporaries, a humble expansion to their knowledge of the disease, based on the searched literature, enabling a more comprehensive management of this rare occurrence.
Fulltext Effectiveness of posthemodialysis administration of pregabalin (75 mg) in treatment resistance uremia pruritus

Khan TM, Aziz A, Suleiman AK

J Pharm Bioallied Sci, 2016 3 10;8(1):74-6.
PMID: 26957874 DOI: 10.4103/0975-7406.171736

Uremic pruritus (UP) is one of the complications faced by majority of the patients with end stage renal disease (ESRD). Due to complex pathophysiology of UP, most of the anti-inflammatory and tropical lubricants often not provide a long lasting control over pruritus. Recently the uses of certain anti-epileptics are found to demonstrate promising relief to UP. To test the effect of 75 mg pregabalin in patients with treatment resistance pruritus. Data was prospectively collected from a patient with ESRD and suffering from treatment resistance pruritus. Intensity of pruritus was recorded using 5D-itching scale (5D-IS) and visual analogue scale (VAS). Pre and post assessment was done for this patient, on initial assess the parathyroid hormone level of the patient was 70.5 pg/ml with a serum phosphate level of 2.61 mmol/L. Upon initial assess the VAS score was 8 and 5D-IS score was twenty. After the duration of four weeks of pregabalin 75 mg post hemodialysis, 5D-IS score reduced to 8 and VAS score move down to 3. Pregabalin 75 mg post hemodialysis was found to reduce the intensity of UP. Pregabalin 75 mg post hemodialysis can be another option to treat UP.
Fulltext A cross-sectional assessment of health-related quality of life among type 2 diabetic patients in Pakistan

Nazir SU, Hassali MA, Saleem F, Bashir S, Hashmi F, Aljadhey H

J Pharm Bioallied Sci, 2016 Jan-Mar;8(1):64-8.
PMID: 26957872 DOI: 10.4103/0975-7406.171734

OBJECTIVE: This study aims to describe the health-related quality of life (HRQoL) profile of Type 2 diabetes mellitus (T2DM) population attending outpatient clinics in Sargodha City, Pakistan.
METHODS: The study was designed as a cross-sectional descriptive survey. T2DM patients attending a tertiary care institute in Sargodha, Pakistan were targeted for the study. The EuroQol EQ-5D was used for the assessment of HRQoL and was scored using values derived from the UK general population survey. Descriptive statistics were used for the elaboration of sociodemographic characteristics. The Chi-square test was used to depict the possible association between study variables and HRQoL. Where significant associations were noted, Phi/Cramer's V was used for data interpretation accordingly. SPSS version 21 (SPSS Inc., Chicago, IL, USA) was used for data analysis and P < 0.05 was taken as significant.
RESULTS: Three hundred and ninety-two patients were approached for the study. The cohort was dominated by males (n = 222, 56.60%) with 5.58 ± 4.09 years of history of T2DM. The study highlighted poor HRQoL among the study participants (0.471 ± 0.336). Gender, marital status, education, monthly income, occupation, location and duration of the disease were reported to be significantly associated with HRQoL (P < 0.001).
CONCLUSION: T2DM imposes a negative effect on HRQoL of the patients. Attention is needed to highlight determinants of HRQoL and to implement policies for better management of T2DM, particularly in early treatment phases where improving HRQoL is still possible.
KEYWORDS: EQ-5D; Pakistan; health-related quality of life; type 2 diabetes mellitus
Fulltext Knowledge, perceptions, and attitudes toward complementary and alternative medicines among pharmacy students of a Malaysian public university

Jamshed SQ, Khan MU, Ahmad A, Elkalmi RM

J Pharm Bioallied Sci, 2016 3 10;8(1):34-8.
PMID: 26957866 DOI: 10.4103/0975-7406.171686

BACKGROUND: The use of complementary and alternative medicine (CAM) is consistently on the rise worldwide. Consumers often consider pharmacists as a major source of information about CAM products and their safety. Due to the limitation of data, it is worth exploring the knowledge, perceptions, and attitudes of pharmacy students toward CAM.
OBJECTIVE: The objective of this study was to explore the knowledge, perceptions, and attitudes of pharmacy students regarding the use of CAM in Malaysia.
MATERIALS AND METHODS: A cross-sectional study was conducted for 3 months among Bachelor of Pharmacy students in a public sector University of Malaysia. A pretested, self-administered questionnaire, comprised four sections, was used to collect the data from 440 participants. Descriptive analysis was used, and Chi-square test was used to test the association between dependent and independent variables.
RESULTS: Of 440 questionnaire distributed, 287 were returned giving a response rate of (65.2%). The results showed that 38.6% participants gave correct answers when asked about the use of herbal products with digoxin. Majority of the participants were knowledgeable about supplementary therapy (25.3%) while the lack of knowledge was mostly evident in traditional Chinese medicines (73.7%). Majority of the students were either neutral (49.5%) or disagreed that (42.8%) CAM use is unsafe. Females were more in disagreement to the statements than males (P = 0.007). Majority of students also agreed to use CAM therapies for their health and well-being (51.2%).
CONCLUSION: The study revealed that pharmacy students did not have adequate knowledge of CAM though their attitudes and perceptions were relatively positive.
Fulltext Journal of Pharmacy and Bioallied Sciences

Jamshed SQ

J Pharm Bioallied Sci, 2016 Jan-Mar;8(1):1.
PMID: 26957861 DOI: 10.4103/0975-7406.173860
Fulltext Knowledge and perception about health risks of cigarette smoking among Iraqi smokers

Dawood OT, Rashan MA, Hassali MA, Saleem F

J Pharm Bioallied Sci, 2016 Apr-Jun;8(2):146-51.
PMID: 27134468 DOI: 10.4103/0975-7406.171738

BACKGROUND:
Smoking is a major public health problem, especially in Iraq. There is very little information had been documented regarding smoking risk factors and quit intention among Iraqi smokers.

OBJECTIVES:
The main objectives of this study are to determine smokers' knowledge and perception about smoking health risks; and to determine smoking behavior and quitting intentions among Iraqi smokers; as well as to predict the factors that may associate with quit intentions.

METHODS:
A cross-sectional study was conducted at the outpatient clinic in Tikrit Teaching Hospital, Tikrit City, Iraq. Adult smokers who are smoking cigarette everyday and able to communicate with the researcher were invited to participate in the study. A self-administered questionnaire was used to collect data from 386 participants.

RESULTS:
This study showed that smokers had low awareness about some risk effects of smoking such as lung cancer in nonsmokers (30.1%), impotence in male smokers (52.6%), premature ageing (64%), and stroke (66.3%). In addition, the high score of knowledge and perception was significantly associated with quitting intention.

CONCLUSION:
Smokers' knowledge and perception regarding smoking health effects were low, especially in terms of secondhand smokers. Many efforts needed from health policy-makers and health care professionals to disseminate information about the risks of smoking and health benefits of give up smoking.

KEYWORDS:
Health risks; knowledge; perception; quit intentions; smoking
Fulltext The use of psychotropic substances among students: The prevalence, factor association, and abuse

Mamat CF, Jamshed SQ, El Syed T, Khan TM, Othman N, Al-Shami AK, et al.

J Pharm Bioallied Sci, 2015 Jul-Sep;7(3):181-7.
PMID: 26229351 DOI: 10.4103/0975-7406.160011

This detailed review analyzed the previously published studies related to the prevalence of psychotropic substances use, associated factors, and the misuse of the psychotropics among students. A comprehensive literature search covering six databases was performed. References from published articles and reports were extracted. This helped in identifying the available information on the use of psychotropic drugs. A total of 16 articles were included in this review. There is an upsurge of using psychotropics with the preceding years. More students are exposed to the risk of using psychotropic substances due to the multiple factors like stress, increased academic workload, etc. The misuse is found to be common with prescribed psychotropic substances. Students need to be aware of the bad outcomes of using psychotropic substances. Participation of every stakeholder to curb this menace needs to be emphasized. More extensive studies are required to know about the increasing prevalence, factors, and misuse of psychotropics.
Fulltext The Development and Validation of Quality of Life Scale for Iraqi Patients with Type 2 Diabetes Mellitus

Mikhael EM, Hassali MA, Hussain SA, Shawky N

J Pharm Bioallied Sci, 2020 07 18;12(3):262-268.
PMID: 33100785 DOI: 10.4103/jpbs.JPBS_190_19

Background and Aim: The current trend for determining the effectiveness of new treatment or services provided for diabetes mellitus (DM) patients is based on assessing the improvement in both glycemic control and the patient quality of life. Many scales have been developed to assess quality of life among DM patients, but unfortunately, no one can be considered as gold standard. Therefore, this study aimed to develop and validate a brief and specific scale to assess quality of life among Iraqi type 2 DM patients.
Methods: An extensive literature review was done using Google-Scholar and PubMed to find out scales that utilized to assess quality of life among DM patients. Four relevant scales, three diabetes specific and one general, were selected. The selected scales were carefully evaluated to find out domains that are commonly used to assess quality of life and then the items within the selected domains were reviewed to choose relevant and comprehensive items for Iraqi type 2 DM patients. Ten items were selected to formulate the quality of life scale for Iraqi DM patients (QOLSID). The content validity of QOLSID was established via an expert panel. For concurrent validity QOLSID was compared to glycosylated hemoglobin (HbA1C). For psychometric evaluation, a cross sectional study for 103 type 2 DM patients was conducted at the National Diabetes Center, Iraq. Test-retest reliability was measured by re-administering QOLSID to 20 patients 2-4 weeks later.
Results: The internal consistency of the QOLSID was 0.727. All items had a corrected total-item correlation above 0.2. There was a negative significant correlation between QOLSID score and the HbA1C level (-0.518, P = 0.000). A significant positive correlation was obtained after re-testing (0.967, P = 0.000).
Conclusion: The QOLSID is a reliable and valid instrument that can be used for assessing quality of life among Iraqi type 2 DM patients.
Fulltext Impact assessment of pharmacist-supervised intervention on health-related quality of life of newly diagnosed diabetics: A pre-post design

Upadhyay DK, Mohamed Ibrahim MI, Mishra P, Alurkar VM

J Pharm Bioallied Sci, 2020 07 18;12(3):234-245.
PMID: 33100782 DOI: 10.4103/jpbs.JPBS_6_20

Introduction: Diabetics face a series of challenges that affect all aspects of their daily life. Diabetes related complications adversely affect patient's health-related quality of life (HRQoL). Knowledge and self-care skills of diabetics are corner stones to improve their HRQoL.
Objective: To assess the impact of pharmacist-supervised intervention on HRQoL of newly diagnosed diabetics using an Audit of Diabetes-Dependent Quality of Life (ADDQoL) questionnaire.
Materials and Methods: A pre-post comparison study was conducted among the control group (CG), test 1 group (T1G) and test 2 group (T2G) patients with three treatment arms to explore the impact of pharmacist-supervised intervention on HRQoL of newly diagnosed diabetics for 18 months. Patients' HRQoL scores were determined using ADDQoL questionnaire at baseline, 3, 6, 9 and 12-months. T1G patients received pharmacist's intervention whereas T2G patients received diabetic kit demonstration in addition to pharmacist's intervention. CG patients were deprived of pharmacist intervention and diabetic kit demonstration, and only received care from attending physician/nurses. Non-parametric tests were used to find the differences in an average weighted impact scores (AWIS) among the groups before and after the intervention at P ≤ 0.05.
Results: Friedman test identified significant (P < 0.001) improvement in AWIS among the test groups' patients. Differences in scores were significant between T1G and T2G at 6-months (P = 0.033), 9-months (P < 0.001) and 12-months (P < 0.001); between CG and T1G at 12-months (P < 0.001) and between CG and T2G at 9-months (P < 0.001) and 12-months (P < 0.0010) on Mann.Whitney U test.
Conclusion: Pharmacist's intervention improved AWIS of test groups' diabetics. Diabetic kit demonstration strengthened the disease understanding and selfcare skills of T2G patients. Disease and self-care awareness among diabetics should be increased in Nepali healthcare system by involving pharmacists for better patient's related outcomes.
Fulltext Phytochemicals and biological activity of Tetracera scandens Linn. Merr. (Dilleniaceae): A short review

Nokhala A, Siddiqui MJ

J Pharm Bioallied Sci, 2020 07 18;12(3):217-222.
PMID: 33100780 DOI: 10.4103/jpbs.JPBS_192_19

Tetracera scandens is a southeast Asian shrub that belongs to family Dilleniaceae. Over the years, different parts of the plant have been used for the management of different diseases, including diabetes mellitus, hypertension, rheumatism, diarrhea, hepatitis, and inflammation. This variety of medical indications has attracted the attention of many researchers to this plant species, leading to the conduction of many research studies on different parts of the plant. These studies have confirmed some of the aforementioned activities of the plant, whereas other indications remain to be ascertained. This article is an attempt to summarize the studies conducted on T. scandens and to explore the isolated phytochemicals.
Fulltext Thymoquinone content in marketed black seed oil in Malaysia

Alkhatib H, Mawazi SM, Al-Mahmood SMA, Zaiter A, Doolaanea AA

J Pharm Bioallied Sci, 2020 07 18;12(3):284-288.
PMID: 33100788 DOI: 10.4103/jpbs.JPBS_208_20

Thymoquinone (TQ) is the major active compound in black seed oil (BSO). Many pharmacological effects of TQ, such as anti-inflammatory, hypoglycemic, antioxidant, immune stimulator, and anticancer, have been reported. TQ can be considered as a biomarker for BSO, but its content in the commercial products is rarely reported. TQ content varies based on the oil source and extraction method. This study aimed to quantify the TQ content in the commercial BSO products in Malaysia and to evaluate whether the products can be used as a source of TQ for therapeutic benefits. TQ was quantified using an established high-performance liquid chromatography (HPLC) method. TQ human equivalent dose (HED) was calculated based on reported animal studies from literature, and theoretical BSO amount containing the TQ dose was calculated based on the HPLC analysis. TQ content in the commercial BSO products ranged from 0.07% wt/wt to 1.88% wt/wt. The product with the highest TQ concentration is approximately 27-fold higher than the product with the lowest TQ concentration. Consequently, theoretical BSO amounts needed for specific diseases varied and some products cannot provide practical amount of TQ. This study recommends the regulation of TQ content in BSO and suggests that the BSO might be fortified with extra TQ to be effectively used in some diseases.
Fulltext Comparison of Flexural Strength of Kevlar, Glass, and Nylon Fibers Reinforced Denture Base Resins With Heat Polymerized Denture Base Resins

Kannaiyan K, Biradar Sharashchandra M, Kattimani S, Devi M, Vengal Rao B, Kumar Chinna S

J Pharm Bioallied Sci, 2020 Aug;12(Suppl 1):S399-S403.
PMID: 33149494 DOI: 10.4103/jpbs.JPBS_117_20

Introduction: Polymethyl methacrylate (PMMA) has been widely accepted and used in dentistry owing to its working characteristics, aesthetics and stability in the oral environment, ease in manipulation, and inexpensive processing methods and equipment.
Aim and Objectives: The aim of this study was to evaluate the flexural strength of a high-impact PMMA denture base resin material and flexural strength of a commonly available heat cure PMMA denture base material with Kevlar, glass, and nylon fibers.
Materials and Methods: The test samples were studied under two groups. The Group I (control group) comprised pre-reinforced PMMA (Lucitone 199; Dentsply Sirona Prosthetics, York, Pennsylvania, USA) consisting of 12 samples and second group comprised regular PMMA (DPI, Mumbai, India) reinforced with different fibers. The second test group was further divided into three subgroups as Group 2, Group 3, and Group 4 comprising 12 samples each designated by the letters a-l. All the samples were marked on both ends. A total of 48 samples were tested. Results were analyzed and any P value ≤0.05 was considered as statistically significant (t test).
Results: All the 48 specimens were subjected to a 3-point bending test on a universal testing machine (MultiTest 10-i, Sterling, VA, USA) at a cross-head rate of 2 mm/min. A load was applied on each specimen by a centrally located rod until fracture occurred; span length taken was 50 mm. Flexural strength was then calculated.
Conclusion: Reinforcement of conventional denture base resin with nylon and glass fibers showed statistical significance in the flexural strength values when compared to unreinforced high impact of denture base resin.
Fulltext Comparative Evaluation of pH and In Vitro Cytotoxicity of Zinc Oxide-Ozonated Eugenol and Conventional Zinc Oxide Eugenol as Endodontic Sealers

Ravivarman C, Jeyasenthil A, Ajay R, Nilofernisha N, Karthikeyan R, Rajkumar D

J Pharm Bioallied Sci, 2020 Aug;12(Suppl 1):S73-S77.
PMID: 33149434 DOI: 10.4103/jpbs.JPBS_21_20

Background: Eugenol released from zinc oxide eugenol (ZOE)-based sealants may cause irritation to the periapical tissues and has cytotoxic potential. Ozone therapy has numerous clinical applications with humans because of its bactericidal action, detoxifying effect, stimulation of angiogenesis, and wound-healing capacity. Therefore ozone can be incorporated in ZOE sealer to exploit these properties.
Materials and Methods: Eugenol was ozonated using ozonator machine and the samples were divided into two groups: Group I: zinc oxide eugenol (n = 10) and Group II: zinc oxide-ozonated eugenol (OZOE; n = 10). The pH of the fresh sealer samples and the set samples was measured using calibrated pH meter after predetermined time intervals. Cytotoxicity of the set sealer was evaluated on mouse L929 fibroblasts using cellular metabolic assay.
Results: pH of the samples in Group II was higher when compared to Group I. Group II showed higher cell viability than the Group I.
Conclusion: OZOE sealers can be used as an alternative to the conventional ZOE sealers.
Fulltext Multidisciplinary Approach for the Management of Mandibular Canines with Rare Configuration

Arora S, Gill GS, Abdulla AM, Saluja P, Baba SM, Khateeb SU, et al.

J Pharm Bioallied Sci, 2020 Aug;12(Suppl 1):S635-S639.
PMID: 33149534 DOI: 10.4103/jpbs.JPBS_82_20

It is very rare (2%-6% cases) for a mandibular canine to have two root canals and the incidence of finding two roots with two root canals in a mandibular canine that too bilaterally is almost negligible. This case report discusses the presence and multidisciplinary management of such rarest configuration in both mandibular canines of a female patient. This case shows the importance of recognition of anatomical variations in successful accomplishment of root canal treatment.

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