Clostridium difficile can cause severe diseases with significant morbidity and mortality in infected patients.
The rate of Clostridium difficile infection is high in North America and European countries. Metronidazole
and vancomycin have been recommended as the treatments of choice since 1990s. Recurrent infection
due to Clostridium difficile is common after several days of antibiotic administration. Probiotics have
been used in these patients as an adjunct treatment with some successful findings. However, a detailed
investigation on the use of probiotic for infected patients is still needed, particularly for its real efficacy.