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  1. Cerebral toxoplasmosis in Malaysia: a debilitating disease, an insight from a case study
    Muslim A, Mohd Rustam FR, Mohd Khalid MS, Sahlan N
    Trop Biomed, 2024 Sep 01;41(3):271-275.
    PMID: 39548780 DOI: 10.47665/tb.41.3.006
    Toxoplasmosis is an infectious disease caused by the intracellular protozoan parasite, Toxoplasma gondii. While the infection is typically asymptomatic in healthy individuals, it can progress to cerebral toxoplasmosis, especially in those with human immunodeficiency virus (HIV) or weakened immune systems. In this communication, we present a case of a newly diagnosed HIV infection patient who presented with neurological symptoms. The patient was later diagnosed with probable cerebral toxoplasmosis. The case depicts the severe consequences of toxoplasmosis in immunocompromised patients, highlighting the urgent need to identify those at high risk of contracting the disease and the importance of prophylactic treatment. This requires the necessity for early HIV diagnosis and close monitoring of HIV-positive patients.
  2. Hepatitis B virus infection: Epidemiology and seroprevalence rate amongst Negrito tribe in Malaysia
    Sahlan N, Fadzilah MN, Muslim A, Shaari SA, Abdul Rahman T, Hoh BP
    Med J Malaysia, 2019 08;74(4):320-325.
    PMID: 31424040
    INTRODUCTION: Prevalence of Hepatitis B virus (HBV) infection among the non-indigenous people in Malaysia has been well established and range between 3% and 5%. However, data from the indigenous (Orang Asli) people is still lacking. The Negrito population is the most remotely located Orang Asli tribe with limited access to health care facilities. This study was undertaken to determine the epidemiology and seroprevalence of HBV infection among the Negrito.

    METHODS: Surveys were conducted in five Negrito settlements in Kelantan and Perak states in Malaysia. A total of 150 participants were recruited. Clinical history was taken and physical examination was performed. Five millilitres of whole blood were collected and tested for hepatitis B surface antigen (HBsAg) using electrochemiluminescence immunoassay.

    RESULTS: Participants were mainly from the Bateq (49.3%) and Mendriq (29.4%) sub-tribes. Overall, 13 subjects (8.7 %); nine males and four females were HBsAg positive. Nine of the HBsAg positive subjects were ≥35 years old. All of them had history of home deliver without evidence of antenatal record. Six (46%) of the HBsAg positive subjects had tattoo and body piercing in the past.

    CONCLUSION: The prevalence of HBV infection rate amongst the Negrito tribe is almost three-fold compared to the national rates. The reason for this finding remains unclear. Tattooing, body piercing and vertical transmission could be the main possible routes of transmission of HBV among the Negrito population in Malaysia.

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