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  1. Dohany AL, Upham RW, Manikumaran C, Rapmund G, Saunders JP
    PMID: 411178
    The life cycle of 5 generations of Leptotrombidium (L.) fletcheri infected with Rickettsia tsutsugamushi and reared under ambient temperatures in Malaysia was presented and compared with a colony reared at a constant 27 degrees C (Neal and Barnett, 1961). In general our colony had a longer generation time (average of 54 days from engorged larvae to adult compared with 37 days) and produced fewer eggs (average of 127.9 compared with 900.0) than the comparison colony. Possible factors causing these differences are discussed.
  2. Saunders JP, Brown GW, Shirai A, Huxsoll DL
    Trans R Soc Trop Med Hyg, 1980;74(2):253-7.
    PMID: 6770503
    Serological surveillance for up to two years of 114 patients with laboratory confirmed scrub typhus showed that antibody to Rickettsia tsutsugamushi as demonstrated by the indirect fluorescent antibody test is short-lived. The mean reversion time from mean peak titre (1:499) was 48.9 weeks and the calculated annual reversion rate to a titre less than 1:50 was 61%. This can be used to estimate attack rates based on point prevalence of antibody. The relationship between antibody prevalence and attack rates observed by other workers was confirmed using this model. The possible uses of the finding and its implications in Malaysia are briefly discussed.
  3. Brown GW, Shirai A, Jegathesan M, Burke DS, Twartz JC, Saunders JP, et al.
    Am J Trop Med Hyg, 1984 Mar;33(2):311-5.
    PMID: 6324601
    We studied 1,629 febrile patients from a rural area of Malaysia, and made a laboratory diagnosis in 1,025 (62.9%) cases. Scrub typhus was the most frequent diagnosis (19.3% of all illnesses) followed by typhoid and paratyphoid (7.4%); flavivirus infection (7.0%); leptospirosis (6.8%); and malaria (6.2%). The hospital mortality was very low (0.5% of all febrile patients). The high prevalence of scrub typhus in oil palm laborers (46.8% of all febrile illnesses in that group) was confirmed. In rural Malaysia, therapy with chloramphenicol or a tetracycline would be appropriate for undiagnosed patients in whom malaria has been excluded. Failure to respond to tetracycline within 48 hours would usually suggest a diagnosis of typhoid, and indicate the need for a change in therapy.
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