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  1. Histological assessment of extensive or unresectable central giant cell granulomas treated with denosumab - A case series
    Patel V, Kumar M, Schache A, Hunter KD, Carey B, Rogers SN, et al.
    Oral Surg Oral Med Oral Pathol Oral Radiol, 2024 Nov 28.
    PMID: 39709299 DOI: 10.1016/j.oooo.2024.11.086
    OBJECTIVE: The management of large central giant cell granuloma (CGCG) can pose a significant surgical challenge. In such circumstances, the use of denosumab has been proposed with the literature reporting varying degrees of success. Histopathological assessment of CGCG post-denosumab treatment remains unknown. The current case series aims to address this lack of information and supplement the literature and the debate with evidence.

    STUDY DESIGN: The current case series is a retrospective review of historic cases accumulated from 3 different hospitals. Patients treated with denosumab for large or unresectable GCGC who subsequently underwent either surgical debulk or resection post drug treatment with histological tissue for assessment were included.

    RESULTS: A total of 4 patients were included in this study. All cases showed radiographic response. However histological assessment identified giant cells in 3 of the 4 cases, 2 of which showed clinical recurrence. All cases demonstrated irregular woven bone formation toward the periphery of the lesion suggesting partial response.

    CONCLUSIONS: The current case series provides some insight regarding the response of CGCG to denosumab and preliminary histopathological information toward the ongoing debate regarding the medical management of CGCG. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).

  2. Fulltext Academic Training in Oral and Maxillofacial Surgery - when and how to enter the pathway
    Payne KFB, Higginson J, Basyuni S, Goodson AMC, Chadha A, Elledge R, et al.
    Br J Oral Maxillofac Surg, 2023 Feb;61(2):124-130.
    PMID: 36774281 DOI: 10.1016/j.bjoms.2023.01.003
    Entering into surgical academia can seem a daunting prospect for an oral and maxillofacial surgery (OMFS) trainee. However, the streamlining of academic training by the NIHR to create the integrated academic training (IAT) pathway has simplified academic training and more clearly defined academic positions and entry points for trainees. In this article we review the current NIHR IAT pathway and the various grades and entry points available to OMF surgeons, both pre- and post-doctoral. We highlight the unique challenges facing OMF trainees and provide advice and insight from both junior and senior OMFS academics. Finally, we focus on the planning and application for a doctoral research fellowship - discussing funding streams available to OMF surgeons.
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