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  1. Muhammad Afiq Khairil Anuar, Siti Zanariah Ab Aziz, Raizulnasuha Abdul Rashid, Safri Zainal Abidin, Norhayati Dollah, Wan Nordiana A. Abd Rahman
    MyJurnal
    Radiotherapy has become the most important modality in treating cancer with approximately 50% of
    cancer patient undergo the treatment. However, more improvement to the radiotherapy treatment
    efficacy is required to deprive cancer. Assessment of tumor progress during treatment is important, to
    accommodate the changes that occur during the fractionation course. The objective of this study is to
    assess tumor cell damage after external beam radiotherapy by using technetium-99m
    pertechnetate (99mTcOf) as a tracer. In this study, HeLa cells were irradiated with 6 MVphoton beam
    with different radiation dose ranging from 0.5 Gy to 10 Gy. The irradiated cells were recultured in 6-
    well plates and incubated for 10 days. After that, 2 mCi of 99mTcOf were prescribed to each cell
    colonies. The viable cells were separated from the rest, and measured for 99mTcOf uptake using singlehead
    gamma camera with LEHR collimation. As results, the cells survival, fractions clearly indicate
    diminishing effect, to the cells at, higher dose of irradiation. Good correlation were observed between
    mmTcGi uptake and survival, fraction for cells irradiated at, lower dose and less significant, correlation
    were indicated at higher dose. In conclusion, there is potential for the efficacy of external beam
    radiotherapy in treating cancer to be assessed by using radioisotope as a non-invasive tracer. In this
    case, technetium-99m, pertechnetate (99mTcOjt) could be attached to the specific antibody so that, better
    correlation, between, the cells uptake and possible cell damages could be observed.
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