We propose the use of a truncated ball lens in a collimating system to transform a spherical wave from a highly divergent source into a plane wave. The proposed scheme, which incorporates a hyperbolic lens, is discussed, and the overall system is found to have a large acceptance angle and to be free of spherical aberration. Diffraction and polarization effects are neglected, as well as skew rays.
A novel fiber tapering shape, which is based on compound parabolic geometry, is proposed to increase the acceptance angle of a compound parabolic concentrator. The proposed design is described by use of ray optics on a step-index multimode fiber.
Forests and agricultural lands are the main resources on the earth's surface and important indicators of regional ecological environments. In this paper, Landsat images from 1990 and 2017 were used to extract information on forests in Malaysia based on a remote-sensing classification method. The spatial-temporal changes of forests and agricultural lands in Malaysia between 1990 and 2017 were analyzed. The results showed that the natural forests in Malaysia decreased by 441 Mha, a reduction of 21%. The natural forests were mainly converted into plantations in Peninsular Malaysia and plantations and secondary forests in East Malaysia. The area of agricultural lands in Malaysia increased by 55.7%, in which paddy fields increased by 1.1% and plantations increased by 98.2%. Paddy fields in Peninsular Malaysia are mainly distributed in the north-central coast and the Kelantan Delta. The agricultural land in East Malaysia is dominated by plantations, which are mainly distributed in coastal areas. The predictable areas of possible expansion for paddy fields in Peninsular Malaysia's Kelantan (45.2%) and Kedah (16.8%) areas in the future are large, and in addition, the plantations in Sarawak (44.7%) and Sabah (29.6%) of East Malaysia have large areas for expansion. The contradiction between agricultural development and protecting the ecological environment is increasingly prominent. The demand for agriculture is expected to increase further and result in greater pressures on tropical forests. Governments also need to encourage farmers to carry out existing land development, land recultivation, or cooperative development to improve agricultural efficiency and reduce the damage to natural forests.
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling1 and is altered in over 20% of cancers2,3. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, called AU-15330. Androgen receptor (AR)+ forkhead box A1 (FOXA1)+ prostate cancer cells are exquisitely sensitive to dual SMARCA2 and SMARCA4 degradation relative to normal and other cancer cell lines. SWI/SNF ATPase degradation rapidly compacts cis-regulatory elements bound by transcription factors that drive prostate cancer cell proliferation, namely AR, FOXA1, ERG and MYC, which dislodges them from chromatin, disables their core enhancer circuitry, and abolishes the downstream oncogenic gene programs. SWI/SNF ATPase degradation also disrupts super-enhancer and promoter looping interactions that wire supra-physiologic expression of the AR, FOXA1 and MYC oncogenes themselves. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide, even inducing disease remission in castration-resistant prostate cancer (CRPC) models without toxicity. Thus, impeding SWI/SNF-mediated enhancer accessibility represents a promising therapeutic approach for enhancer-addicted cancers.