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Challenges in the Ethical Review of Clinical and Biomedical Research in Malaysia: A Mixed Methods Study

See HY, Mohamed MS, Nor SNM, Low WY

J Empir Res Hum Res Ethics, 2021 12;16(5):487-500.
PMID: 34292842 DOI: 10.1177/15562646211033191

Empirical evidence of the ethical review of clinical and biomedical research in Malaysia is limited. We have conducted a convergent mixed methods research, which comprises an online survey and semistructured interviews to examine the challenges in the ethical review of clinical and biomedical research. Data collected reveal that the ethics review process is inconsistent, duplicate, and inadequate. The results indicate a strong need for a centralized ethical review mechanism and a national system for mutual recognition of ethics reviews to improve the effectiveness and efficiency of the ethics review system in Malaysia. A joint research ethics committee review between Malaysia and sponsoring countries for multinational research should also be encouraged as it could address the concerns of the lack of expertise and training.
Fulltext Development and evaluation of a Physiotherapy-led, WHO-ICOPE-Based, Person-Centered Integrated Care Program (PTICOPE) module to enhance intrinsic capacity in older adults: Protocol for a randomized controlled trial

Noordin N, Siriphorn A, Chye Wah Y, Justine M

PLoS One, 2025;20(3):e0318513.
PMID: 40106417 DOI: 10.1371/journal.pone.0318513

BACKGROUND: Declining intrinsic capacity (IC), encompassing domains such as locomotion, cognitive function, vitality, vision, hearing, and psychological well-being, is prevalent among older adults, impacting independence and quality of life (QoL). This study aims to develop and evaluate the Physiotherapy-led Person-Centered Integrated Care for Older People (PTICOPE) based on the WHO-ICOPE framework to enhance IC among older adults in Malaysia.
METHODS: This is a 12-week, multicenter, randomized controlled trial involving 70 community-dwelling older adults aged 60-75, recruited from three Pusat Aktiviti Warga Emas (PAWE) (Activity Center for Older Adults) in the Northern region of Malaysia. Participants will be randomized to either the intervention group, receiving the PTICOPE module workbook and guided use, or the control group, receiving general IC information, healthcare education, and self-care management. The recruitment of participants for this study has not yet commenced. Recruitment is expected to start after completing the validation of the PTICOPE module, however, it is anticipated that the recruitment start date is in February 2025 and will end in August 2025. Primary outcomes, including locomotor, psychological, cognitive, vitality, visual, and hearing functions using validated scales, will be collected at baseline, 4th, 8th, and 12th week of the study period. Secondary outcomes will evaluate QoL, activities of daily living, urogenital health, and oral health at baseline and 12th week. The normality of data will be checked. The independent t-tests, Chi-square tests, paired t-tests, and Repeated measures ANOVA will be used for data analysis, with a significant level at p
Fulltext Effects of stress and self-efficacy on quality of life of mothers with autistic children: Covariance-Based Structural Equation Modeling (CB-SEM) approach

Bee Wah Y, Mohd Nasir NN, Hadrawi MF, Kamaruddin AA, Jannoo Z, Afthanorhan A

Belitung Nurs J, 2024;10(2):201-208.
PMID: 38690312 DOI: 10.33546/bnj.3096

BACKGROUND: Mothers who have children with autism encounter significant difficulties in caring for their autistic youngsters, leading to higher stress levels and a reduced overall quality of life. External or internal factors can cause and respond to stress, affecting an individual's physical, psychological, and emotional health. Thus, it is crucial to examine the quality of life of mothers with autistic children.
OBJECTIVES: This study aimed to investigate the relationships between stress, self-efficacy, and quality of life (QoL) in mothers of children with autism.
METHODS: A cross-sectional study design was used. Self-administered questionnaires were distributed from October to November 2019 to mothers with autistic children using cluster sampling techniques to capture their demographics and perceptions of stress, self-efficacy, and QoL. The data analysis was performed using covariance-based structural equation modeling (CB-SEM).
RESULTS: Of the 290 questionnaires distributed, 238 (response rate of 82%) sets were returned, but only 181 questionnaires were usable for further analysis. The findings demonstrated a notable impact of stress and self-efficacy on quality of life and an adverse effect of stress on self-efficacy. Self-efficacy serves as an intermediary in the relationship between stress and quality of life.
CONCLUSION: In general, mothers of autistic children typically face moderate stress levels, but they have low levels of self-efficacy and quality of life. Mothers of children with autism need assistance and support from healthcare professionals, such as doctors, nurses, and psychiatrists, so that they can bear the challenges of raising children with special needs and enjoy a higher standard of living with less emotional and physical strain.
Abstracts of the 34th World Congress on Ultrasound in Obstetrics and Gynecology, 15-18 September 2024, Budapest, Hungary

Hoang LN, Dinh LT, Tai S, Nguyen D, Pooh RK, Shiozaki A, et al.

Ultrasound Obstet Gynecol, 2024 Sep;64 Suppl 1:33-34.
PMID: 39249221 DOI: 10.1002/uog.27809