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  1. Dataset on characterisation and stability of gingival retraction cord lignocaine-adrenaline nanogel optimised using central composite design
    Azman MM, Haris MS, Lestari W, Husain J, Abdul Qader OAJ, Wan Abd Manan WNH
    Data Brief, 2024 Dec;57:111028.
    PMID: 39534064 DOI: 10.1016/j.dib.2024.111028
    This study aims to characterise and assess the stability of an optimised lignocaine-adrenaline nanogel using central composite design (CCD). Compatibility studies were conducted using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) and Ultraviolet-visible (UV-vis) spectroscopy. Eighteen lignocaine-adrenaline Nanoemulsion (LANE) formulations derived using CCD were characterised for particle size, polydispersity index (PDI), zeta potential and pH. All LANE formulations were transformed into lignocaine-adrenaline Nanoemulsion-based Gel (NBG) by adding 0.1 % Carbopol 940. Stability studies for LANE and NBG were conducted for 12 months storage at 25 °C. The results of long-term stability assessment of LANEs and NBGs were integrated with CCD predictions to produce the optimised NBG, lignocaine-adrenaline Nanogel. The optimised NBG model was validated in triplicates. The optimised NBG was subjected to 5000 rpm centrifugation for 30 min, repeated heating-cooling cycles (40 °C and 4 °C), and a freeze-thaw cycle (-5 °C and 25 °C). ATR-FTIR and UV-vis results indicated compatibility between lignocaine, adrenaline and the excipients. The viscosity of the nanogel corresponded to that of ferric sulphate solution (24 ± 1 mPa·s at 20 °C). The LANE and NBG formulations showed no drug precipitation or phase separation after the stability study. The optimised NBG had particle size (61.76 ± 0.25 nm), PDI (0.36 ± 0.01), zeta potential (-26.47 ± 0.02 mV) and pH (6.28 ± 0.02). The optimised NBG remained stable in stress-induced environments. CCD enabled optimisation of a stable NBG formulation.
  2. Impact of WhatsApp on improving denture care knowledge and the awareness of the relationship between edentulism and general health
    Wan Abd Manan WNH, Abg Abd Mohd Rizal DNS, Borhan FW, Lestari W, Ismail A, Che Musa MF, et al.
    J Prosthet Dent, 2024 Nov 29.
    PMID: 39616100 DOI: 10.1016/j.prosdent.2024.11.004
    STATEMENT OF PROBLEM: Denture wearers are susceptible to diseases related to denture hygiene and are more prone to develop systemic disease because of poor understanding and awareness of the impact of edentulism on general health.

    PURPOSE: The purpose of this clinical study was to evaluate the effectiveness of traditional chairside practice and WhatsApp in improving patient knowledge of denture care and their awareness of the impact of edentulism on general health.

    MATERIAL AND METHODS: Sixty-two participants who attended the Polyclinic Kulliyyah of Dentistry, IIUM Kuantan in 2022 for removable prosthesis fabrication were recruited. The participants were randomized into 2 groups: control (traditional chairside) and intervention (WhatsApp) group. Video intervention was sent via WhatsApp to the participants. Pretreatment and posttreatment questionnaires were distributed from March to September 2022 to survey their sociodemographic data, knowledge of denture care, and awareness of the effect of edentulism on general health. Data were obtained and checked for normality using the Shapiro-Wilk test. Data were analyzed using the Mann-Whitney U and Wilcoxon-Paired Signed-Rank tests (α=.05).

    RESULTS: Eighty-two percent of participants favored WhatsApp as a tool for receiving information and used it daily (66.1%). The level of overall knowledge and awareness increased in groups after denture insertion instruction. Participants' knowledge of denture care (P=.001) and awareness of the effect of edentulism on general health (P=.001) improved significantly in the WhatsApp intervention group compared with the control group.

    CONCLUSIONS: WhatsApp can be used as an alternative tool for improving denture care knowledge among denture wearers; increased awareness was observed with WhatsApp compared with the traditional chairside approach.

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