Giant cell arteritis (GCA), also known as temporal arteritis, is a form of vasculitis that primarily affects the large and medium-sized arteries, which can lead to narrowing or blockage of the arteries. When GCA involves vital vessels such as the coronary arteries, aorta, or cerebral arteries, it can pose a serious risk to life. We present a case of a 61-year-old Malay woman with hypertension and chronic kidney disease who presented with a two-day history of sudden-onset visual loss in the right eye preceded by an inferior visual field defect for four days associated with both lower limb pain. Otherwise, there was no fever, headache, scalp pain, or jaw claudication. Her vision was hand movement and 6/6 in the right eye and left eye, respectively, with a positive relative afferent pupillary defect. Fundus examination showed a swollen 'chalky white' pallid appearance of the optic disc with splinter haemorrhage. The examination of the left eye was normal. Both temporal arteries were dilated, tortuous, and non-pulsatile. There were multiple painful necrotic skin lesions over both lower limbs. Blood tests showed a markedly high erythrocyte sedimentation rate (120 mm/hour) and C-reactive protein (144.2 mg/L). The temporal artery biopsy was suggestive of GCA, and the findings were supported by a biopsy from the necrotic skin lesions. She was treated with intravenous methylprednisolone for three days, and her vision maintained hand movement with no involvement of the left eye. She was discharged with oral prednisolone 1 mg/kg; however, one month later, she succumbed to death from cardiac complications.
Endogenous endophthalmitis is an ocular emergency, with severe sight-threatening complications. We report a case of unilateral endogenous Klebsiella pneumonia endophthalmitis with a large sub-retinal abscess in a 39-year-old lady that developed four days after presentation with sepsis secondary to urinary tract infections and pyelonephritis. Despite immediate treatment with intravenous (IV) and intravitreal antibiotics, her eye condition deteriorated. A pars plana vitrectomy was performed, and the sub-retinal abscess was removed, followed by silicone oil tamponade. Subsequently, she regained her vision to 6/36 with complete regression of the intraocular inflammation and sub-retinal abscess.