To compare the value of light-cured composite resin with that of nano-composite resin in dental caries repair. 88 patients taking dental caries repair in our hospital from May 2014 to April 2015 were selected, and divided into observation group and control group by coin method with 44 patients in each group. Nano-composite resin was used in observation group, while light-cured composite resin in control group. Then, the occurrence rates of odontohyperesthesia, aesthetic satisfaction with dental caries repair and complications were compared between two groups by visual analogue scale (VAS). The occurrence rate of odontohyperesthesia in observation group is significantly lower than that in control group (9.09% (4/44) vs 31.82% (14/44), 6.82% (3/44) vs 22.73% (10/44), 2.27% (1/44) vs 13.64% (6/44)) with difference of statistical significance (P<0.05) 1 week, 4 weeks, and 8 weeks after repair. VAS score of patients in observation is significantly lower than that in control group ((2.78±0.56) scores vs (5.22±0.76) scores, (2.02±0.35) scores vs (4.32±0.57) scores, (1.12±0.14) scores vs (2.41±0.43) scores) 1 week, 4 weeks, and 8 weeks after repair. Moreover, the difference in comparison of interactive effects between two groups, between different time points, and between groups at different time points has statistical significance (P<0.05). Nano-composite resin can lower the occurrence rate of odontohyperesthesia in dental caries repair, reduce the pain of patients, and improve the satisfaction of patients with tooth appearance.