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  1. Yew SQ, Chia YC, Theodorakis M
    Asia Pac J Public Health, 2019 10;31(7):622-632.
    PMID: 31535566 DOI: 10.1177/1010539519873487
    In this study, we evaluated the performance of the Framingham cardiovascular disease (CVD) and the United Kingdom Prospective Diabetes Study (UKPDS) risk equations to predict the 10-year CVD risk among type 2 diabetes mellitus (T2DM) patients in Malaysia. T2DM patients (n = 660) were randomly selected, and their 10-year CVD risk was calculated using both the Framingham CVD and UKPDS risk equations. The performance of both equations was analyzed using discrimination and calibration analyses. The Framingham CVD, UKPDS coronary heart disease (CHD), UKPDS Fatal CHD, and UKPDS Stroke equations have moderate discrimination (area under the receiver operating characteristic [aROC] curve = 0.594-0.709). The UKPDS Fatal Stroke demonstrated a good discrimination (aROC curve = 0.841). The Framingham CVD, UKPDS Stroke, and UKPDS Fatal Stroke equations showed good calibration (P = .129 to .710), while the UKPDS CHD and UKPDS Fatal CHD are poorly calibrated (P = .035; P = .036). The UKPDS is a better prediction equation of the 10-year CVD risk among T2DM patients compared with the Framingham CVD equation.
  2. Yew SQ, Trivedi D, Adanan NIH, Chew BH
    BMJ Open, 2024 Jan 31;14(1):e078508.
    PMID: 38296272 DOI: 10.1136/bmjopen-2023-078508
    INTRODUCTION: The implementation of digital health technologies (DHTs) in hospitals worldwide has been uneven since the COVID-19 pandemic. Ambiguity in defining the landscape of DHTs adds to the complexity of this process. To address these challenges, this scoping review aims to identify the facilitators and barriers of implementing DHTs in hospitals in lower-income and middle-income countries (LMIC) since COVID-19, describe the DHTs that have been adopted in hospital settings in LMIC during this period, and develop a comprehensive classification framework to define the landscape of DHTs implemented in LMIC.

    METHODS AND ANALYSIS: We will conduct a systematic search in PubMed, Scopus, Web of Science and grey literature. Descriptive statistics will be used to report the characteristics of included studies. The facilitators and barriers to DHTs implementation, gathered from both quantitative and qualitative data, will be synthesised using a parallel-results convergent synthesis design. A thematic analysis, employing an inductive approach, will be conducted to categorise these facilitators and barriers into coherent themes. Additionally, we will identify and categorise all available DHTs based on their equipment types and methods of operation to develop an innovative classification framework.

    ETHICS AND DISSEMINATION: Formal ethical approval is not required, as primary data collection is not involved in this study. The findings will be disseminated through peer-reviewed publications, conference presentations and meetings with key stakeholders and partners in the field of digital health.

  3. Yew SQ, Tan KA, Nazan AINM, Manaf RA
    PMID: 38057094 DOI: 10.1265/ehpm.23-00223
    BACKGROUND: Non-adherence to anti-hypertensive medications can lead to hypertension-related complications. One of the most effective preventive measures to mitigate these complications is to understand the underlying determinants of medication non-adherence using various scales. Unfortunately, existing scales for measuring non-adherence to anti-hypertensive medications have certain limitations, such as insufficient consideration of validity, dimensionality, and cultural adaptation. In response, the current study aimed to develop and validate a measure of non-adherence to anti-hypertensive medications-known as the Malaysian Anti-hypertensive Agent Non-Adherence Scale (MAANS)-for use in local hypertensive patients.

    METHODS: A two-phase mixed-methods approach was used. Phase 1 involved qualitative interviews with hypertensive patients from two health clinics in Kuala Lumpur, Malaysia. The themes extracted from these interviews were used to generate items for the MAANS. In Phase 2, data from 213 participants were analysed using exploratory factor analysis (EFA) to establish the scale's factor structure, thereby created the modified version of the MAANS. Confirmatory factor analysis (CFA) was then conducted on a separate dataset of 205 participants to confirm the factor structure, resulted in the final version of the MAANS. The reliability of the final MAANS version was assessed using Cronbach's alpha coefficient. The MAANS scores were used to predict subscales of the Malay version of the WHO Quality-of-Life (QOL) BREF, demonstrating the scale's predictive validity.

    RESULTS: Ten qualitative interviews yielded 73 items. The EFA produced a modified MAANS with 21 items grouped into five factors. However, the CFA retained three factors in the final scale: Perceived Non-Susceptibility, Poor Doctor-Patient Relationship, and Unhealthy Lifestyle. The final 14-item, 3-factor MAANS demonstrated moderate reliability (Cronbach's alpha coefficient = 0.64) and exhibited partial predictive validity, with the Poor Doctor-Patient Relationship and Unhealthy Lifestyle subscales significantly predicting Social QOL and Environmental QOL.

    CONCLUSION: The MAANS is a reliable, valid, and multidimensional scale specifically developed to evaluate non-adherence to anti-hypertensive medications in local clinical settings with the potential to further the advancement of research and practice in sociomedical and preventive medicine.

  4. Ismail H, Phan YH, Chandriah K, Arman MR, Mokhtar NN, Hamdan SA, et al.
    Heliyon, 2023 Sep;9(9):e20258.
    PMID: 37809997 DOI: 10.1016/j.heliyon.2023.e20258
    INTRODUCTION: This study was aimed to measure the prevalence of depression, anxiety, and stress as well as to evaluate the associations of these mental disorders with sociodemographic factors, workplace worries, and coping strategies among frontline HCWs in Kuala Lumpur, Malaysia during the COVID-19 pandemic.

    METHODS: A cross-sectional study was conducted in a tertiary teaching hospital in Kuala Lumpur, Malaysia. Sociodemographic data questionnaire, Depression, Anxiety, and Stress Scale 21, sources of workplace worries questionnaire, and Brief-COPE inventory were randomly distributed to frontline HCWs who worked at the medical, emergency, and anaesthesiology departments. Data were analyzed using Chi-square tests and multivariable linear regression analysis.

    RESULTS: A total of 137 frontline HCWs responded to the questionnaires. The prevalence of depression, anxiety, and stress was 69.3%, 77.4%, and 57.7%, respectively. None of the sociodemographic characteristics was associated with depression, anxiety, and stress. Depression was associated to all sources of workplace worries, except "fear of getting infected" (p = 0.089), while anxiety and stress were associated with all sources of workplace worries. Humour (β = 0.821), self-blame (β = 0.686), denial (β = 0.676), substance use (β = 0.835), and behavioural disengagement (β = 0.583) were positively correlated to depression. However, active coping (β = -0.648) and acceptance (β = -0.602) were negatively correlated to depression. On the other hand, active coping (β = 0.913), planning (β = 0.879), acceptance (β = 0.831), religion (β = 0.704), and self-distraction (β = 0.929) were positively correlated to stress. Only substance use (β = -0.417) was negatively correlated to stress. All coping strategies did not correlate to anxiety.

    CONCLUSION: The high prevalence of depression, anxiety and stress is attributed by the various sources of workplace worries and the inappropriate coping strategies among the frontline HCWs. Measures that minimise workplace worries and inappropriate coping strategies must be implemented promptly.

  5. Ismail H, Dawam D, Muhd Aris NA, Yew SQ, Ahmad H, David CCH, et al.
    Heliyon, 2024 Jan 15;10(1):e23625.
    PMID: 38173473 DOI: 10.1016/j.heliyon.2023.e23625
    INTRODUCTION: Workplace bullying (WPB) among trainee doctors is a concerning problem in Malaysia. However, there is still limited understanding regarding the influence of trainee doctors' personality traits on WPB. Furthermore, the impact of contract employment status on WPB among trainee doctors is not yet well-defined. To address these gaps, this study was aimed to determine the prevalence of WPB among trainee doctors and to examine the association of sociodemographic characteristics, job characteristics, and personality traits with WPB among trainee doctors in Malaysia.

    METHODS: A multi-center cross-sectional study was conducted with 264 trainee doctors in Selangor, Malaysia. Eligible participants were provided with sociodemographic characteristics questionnaire, job characteristics questionnaire, WPB questionnaire, and the Big Five Inventory-10 (BFI-10). Chi-square tests were used to examine the association between: (i) sociodemographic characteristics and WPB, (ii) job characteristics and WPB; and (iii) personality traits and WPB. Multivariate logistic regression was performed to evaluate the association between the significant independent variables (as determined from Chi-square tests) and WPB.

    RESULTS: The prevalence of WPB was 45.1 %, with verbal abuse being the most common form of bullying (46.2 %). Chi-square test showed that only marital status and low agreeableness were significantly associated with WPB. Subsequently, multiple logistic regression demonstrated that being married (OR: 1.866; 95 % CI: 1.077-3.234) and low agreeableness (OR: 2.287; 95 % CI: 1.169-4.473) were significant predictors of WPB.

    CONCLUSION: The high prevalence of WPB among trainee doctors could be attributed by marriage and low agreeableness personality traits in this population. In order to minimise WPB and maximise workforce potential, it is essential for healthcare institutions and medical training programmes to recognise this vulnerabilities and take steps to protect and support trainee doctors who are married and/or with low agreeableness personality trait.

  6. Yusoff HM, Mohamed NC, Yew SQ, Nawi AM, Rashidah Ismail OH, Tohit NM, et al.
    J Health Popul Nutr, 2024 Nov 25;43(1):194.
    PMID: 39707582 DOI: 10.1186/s41043-024-00696-z
    BACKGROUND: The manufacturing sector in Malaysia has been severely impacted by the COVID-19 pandemic. This is further exacerbated by Long COVID-19 symptoms among the manufacturing workers, which are proven to influence work performance and quality of life. Of note, there is currently a lack of knowledge regarding the burden of Long COVID-19 in the Malaysian manufacturing sector. As such, our study aims to investigate the prevalence and risk factors of Long COVID-19 symptoms among the manufacturing workers, and subsequently assess the prevalence and risk factors of adverse work outcomes among the workers with Long Covid-19 symptoms.

    METHODS: This is an exploratory mixed-methods study. In phase 1 (qualitative phase), three groups of participants (i.e., clinicians, employers, and workers) will be invited to participate to focus group discussions (FGDs) until thematic saturation. The aim of the FGDs is to explore the understanding, experience, and potential risk factors of Long Covid-19 among manufacturing workers. Findings from the FGDs will be analysed thematically. Themes generated from the FGDs will be used to generate items in a new questionnaire. The newly developed questionnaire will be validated using a fuzzy Delphi study, which will also be conducted among clinicians, employers, and workers. Phase 2 is a cross-sectional study that will be conducted among manufacturing workers across all states in Malaysia to identify the prevalence and risk factors of Long COVID-19, as well as the prevalence and risk factors of adverse work outcomes among workers with Long COVID-19. A multistage cluster sampling will be used to collect data from 4500 manufacturing workers in Malaysia. Logistic regression will be performed to determine the association between risk factors with both Long COVID-19 and adverse work outcomes.

    CONCLUSION: Once the prevalence and risk factors of Long COVID and its associated adverse work outcome are identified, timely support and effective interventions could be provided to manufacturing workers to maintain their health and productivity.

    ETHICAL CONSIDERATIONS: Ethical approval has been granted by the Research Ethics Committee of the National University of Malaysia (JEP-2023-607) and the Medical Research and Ethics Committee (MREC) Malaysia (NMRR ID-23-03310-H3E).

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