Mesenchymal stem cells (MSCs) have shown promising ability to treat critical cases of coronavirus disease 2019 (COVID-19) by regenerating lung cells and reducing immune system overreaction. However, two main challenges need to be addressed first before MSCs can be efficiently transfused to the most critical cases of COVID-19. First is the selection of suitable MSC sources that can meet the standards of stem cell criteria. Second is differentiating COVID-19 patients into different emergency levels automatically and prioritising them in each emergency level. This study presents an efficient real-time MSC transfusion framework based on multicriteria decision-making(MCDM) methods. In the methodology, the testing phase represents the ability to adhere to plastic surfaces, the upregulation and downregulation of specific surface protein markers and finally the ability to differentiate into different kinds of cells. In the development phase, firstly, two scenarios of an augmented dataset based on the medical perspective are generated to produce 80 patients with different emergency levels. Secondly, an automated triage algorithm based on a formal medical guideline is proposed for real-time monitoring of COVID-19 patients with different emergency levels (i.e. mild, moderate, severe and critical) considering the improvement and deterioration procedures from one level to another. Thirdly, a unique decision matrix for each triage level (except mild) is constructed on the basis of the intersection between the evaluation criteria of each emergency level and list of COVID-19 patients. Thereafter, MCDM methods (i.e. analytic hierarchy process [AHP] and vlsekriterijumska optimizcija i kaompromisno resenje [VIKOR]) are integrated to assign subjective weights for the evaluation criteria within each triage level and then prioritise the COVID-19 patients on the basis of individual and group decision-making(GDM) contexts. Results show that: (1) in both scenarios, the proposed algorithm effectively classified the patients into four emergency levels, including mild, moderate, severe and critical, taking into consideration the improvement and deterioration cases. (2) On the basis of experts' perspectives, clear differences in most individual prioritisations for patients with different emergency levels in both scenarios were found. (3) In both scenarios, COVID-19 patients were prioritised identically between the internal and external group VIKOR. During the evaluation, the statistical objective method indicated that the patient prioritisations underwent systematic ranking. Moreover, comparison analysis with previous work proved the efficiency of the proposed framework. Thus, the real-time MSC transfusion for COVID-19 patients can follow the order achieved in the group VIKOR results.
In group decision making (GDM), to facilitate an acceptable consensus among the experts from different fields, time and resources are paid for persuading experts to modify their opinions. Thus, consensus costs are important for the GDM process. Notwithstanding, the unit costs in the common linear cost functions are always fixed, yet experts will generally express more resistance if they have to make more compromises. In this study, we use the quadratic cost functions, the marginal costs of which increase with the opinion changes. Aggregation operators are also considered to expand the applications of the consensus methods. Moreover, this paper further analyzes the minimum cost consensus models under the weighted average (WA) operator and the ordered weighted average (OWA) operators, respectively. Corresponding approaches are developed based on strictly convex quadratic programming and some desirable properties are also provided. Finally, some examples and comparative analyses are furnished to illustrate the validity of the proposed models.
Conventional convolutional neural networks (CNNs) present a high computational workload and memory access cost (CMC). Spectral domain CNNs (SpCNNs) offer a computationally efficient approach to compute CNN training and inference. This paper investigates CMC of SpCNNs and its contributing components analytically and then proposes a methodology to optimize CMC, under three strategies, to enhance inference performance. In this methodology, output feature map (OFM) size, OFM depth or both are progressively reduced under an accuracy constraint to compute performance-optimized CNN inference. Before conducting training or testing, it can provide designers guidelines and preliminary insights regarding techniques for optimum performance, least degradation in accuracy and a balanced performance-accuracy trade-off. This methodology was evaluated on MNIST and Fashion MNIST datasets using LeNet-5 and AlexNet architectures. When compared to state-of-the-art SpCNN models, LeNet-5 achieves up to 4.2× (batch inference) and 4.1× (single-image inference) higher throughputs and 10.5× (batch inference) and 4.2× (single-image inference) greater energy efficiency at a maximum loss of 3% in test accuracy. When compared to the baseline model used in this study, AlexNet delivers 11.6× (batch inference) and 5× (single-image inference) increased throughput and 25× (batch inference) and 8.8× (single-image inference) more energy-efficient inference with just 4.4% reduction in accuracy.
As coronavirus disease 2019 (COVID-19) spreads across the world, the transfusion of efficient convalescent plasma (CP) to the most critical patients can be the primary approach to preventing the virus spread and treating the disease, and this strategy is considered as an intelligent computing concern. In providing an automated intelligent computing solution to select the appropriate CP for the most critical patients with COVID-19, two challenges aspects are bound to be faced: (1) distributed hospital management aspects (including scalability and management issues for prioritising COVID-19 patients and donors simultaneously), and (2) technical aspects (including the lack of COVID-19 dataset availability of patients and donors and an accurate matching process amongst them considering all blood types). Based on previous reports, no study has provided a solution for CP-transfusion-rescue intelligent framework during this pandemic that has addressed said challenges and issues. This study aimed to propose a novel CP-transfusion intelligent framework for rescuing COVID-19 patients across centralised/decentralised telemedicine hospitals based on the matching component process to provide an efficient CP from eligible donors to the most critical patients using multicriteria decision-making (MCDM) methods. A dataset, including COVID-19 patients/donors that have met the important criteria in the virology field, must be augmented to improve the developed framework. Four consecutive phases conclude the methodology. In the first phase, a new COVID-19 dataset is generated on the basis of medical-reference ranges by specialised experts in the virology field. The simulation data are classified into 80 patients and 80 donors on the basis of the five biomarker criteria with four blood types (i.e., A, B, AB, and O) and produced for COVID-19 case study. In the second phase, the identification scenario of patient/donor distributions across four centralised/decentralised telemedicine hospitals is identified 'as a proof of concept'. In the third phase, three stages are conducted to develop a CP-transfusion-rescue framework. In the first stage, two decision matrices are adopted and developed on the basis of the five 'serological/protein biomarker' criteria for the prioritisation of patient/donor lists. In the second stage, MCDM techniques are analysed to adopt individual and group decision making based on integrated AHP-TOPSIS as suitable methods. In the third stage, the intelligent matching components amongst patients/donors are developed on the basis of four distinct rules. In the final phase, the guideline of the objective validation steps is reported. The intelligent framework implies the benefits and strength weights of biomarker criteria to the priority configuration results and can obtain efficient CPs for the most critical patients. The execution of matching components possesses the scalability and balancing presentation within centralised/decentralised hospitals. The objective validation results indicate that the ranking is valid.
Machine learning and deep learning models are commonly developed using programming languages such as Python, C++, or R and deployed as web apps delivered from a back-end server or as mobile apps installed from an app store. However, recently front-end technologies and JavaScript libraries, such as TensorFlow.js, have been introduced to make machine learning more accessible to researchers and end-users. Using JavaScript, TensorFlow.js can define, train, and run new or existing, pre-trained machine learning models entirely in the browser from the client-side, which improves the user experience through interaction while preserving privacy. Deep learning models deployed on front-end browsers must be small, have fast inference, and ideally be interactive in real-time. Therefore, the emphasis on development and deployment is different. This paper aims to review the development and deployment of these deep-learning web apps to raise awareness of the recent advancements and encourage more researchers to take advantage of this technology for their own work. First, the rationale behind the deployment stack (front-end, JavaScript, and TensorFlow.js) is discussed. Then, the development approach for obtaining deep learning models that are optimized and suitable for front-end deployment is then described. The article also provides current web applications divided into seven categories to show deep learning potential on the front end. These include web apps for deep learning playground, pose detection and gesture tracking, music and art creation, expression detection and facial recognition, video segmentation, image and signal analysis, healthcare diagnosis, recognition, and identification.
According to the World Health Organization, millions of infections and a lot of deaths have been recorded worldwide since the emergence of the coronavirus disease (COVID-19). Since 2020, a lot of computer science researchers have used convolutional neural networks (CNNs) to develop interesting frameworks to detect this disease. However, poor feature extraction from the chest X-ray images and the high computational cost of the available models introduce difficulties for an accurate and fast COVID-19 detection framework. Moreover, poor feature extraction has caused the issue of 'the curse of dimensionality', which will negatively affect the performance of the model. Feature selection is typically considered as a preprocessing mechanism to find an optimal subset of features from a given set of all features in the data mining process. Thus, the major purpose of this study is to offer an accurate and efficient approach for extracting COVID-19 features from chest X-rays that is also less computationally expensive than earlier approaches. To achieve the specified goal, we design a mechanism for feature extraction based on shallow conventional neural network (SCNN) and used an effective method for selecting features by utilizing the newly developed optimization algorithm, Q-Learning Embedded Sine Cosine Algorithm (QLESCA). Support vector machines (SVMs) are used as a classifier. Five publicly available chest X-ray image datasets, consisting of 4848 COVID-19 images and 8669 non-COVID-19 images, are used to train and evaluate the proposed model. The performance of the QLESCA is evaluated against nine recent optimization algorithms. The proposed method is able to achieve the highest accuracy of 97.8086% while reducing the number of features from 100 to 38. Experiments prove that the accuracy of the model improves with the usage of the QLESCA as the dimensionality reduction technique by selecting relevant features.
Software Fault Prediction (SFP) is an important process to detect the faulty components of the software to detect faulty classes or faulty modules early in the software development life cycle. In this paper, a machine learning framework is proposed for SFP. Initially, pre-processing and re-sampling techniques are applied to make the SFP datasets ready to be used by ML techniques. Thereafter seven classifiers are compared, namely K-Nearest Neighbors (KNN), Naive Bayes (NB), Linear Discriminant Analysis (LDA), Linear Regression (LR), Decision Tree (DT), Support Vector Machine (SVM), and Random Forest (RF). The RF classifier outperforms all other classifiers in terms of eliminating irrelevant/redundant features. The performance of RF is improved further using a dimensionality reduction method called binary whale optimization algorithm (BWOA) to eliminate the irrelevant/redundant features. Finally, the performance of BWOA is enhanced by hybridizing the exploration strategies of the grey wolf optimizer (GWO) and harris hawks optimization (HHO) algorithms. The proposed method is called SBEWOA. The SFP datasets utilized are selected from the PROMISE repository using sixteen datasets for software projects with different sizes and complexity. The comparative evaluation against nine well-established feature selection methods proves that the proposed SBEWOA is able to significantly produce competitively superior results for several instances of the evaluated dataset. The algorithms' performance is compared in terms of accuracy, the number of features, and fitness function. This is also proved by the 2-tailed P-values of the Wilcoxon signed ranks statistical test used. In conclusion, the proposed method is an efficient alternative ML method for SFP that can be used for similar problems in the software engineering domain.