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  1. Rahim SS, Palade V, Shuttleworth J, Jayne C
    Brain Inform, 2016 Mar 16.
    PMID: 27747815 DOI: 10.1007/s40708-016-0045-3
    Digital retinal imaging is a challenging screening method for which effective, robust and cost-effective approaches are still to be developed. Regular screening for diabetic retinopathy and diabetic maculopathy diseases is necessary in order to identify the group at risk of visual impairment. This paper presents a novel automatic detection of diabetic retinopathy and maculopathy in eye fundus images by employing fuzzy image processing techniques. The paper first introduces the existing systems for diabetic retinopathy screening, with an emphasis on the maculopathy detection methods. The proposed medical decision support system consists of four parts, namely: image acquisition, image preprocessing including four retinal structures localisation, feature extraction and the classification of diabetic retinopathy and maculopathy. A combination of fuzzy image processing techniques, the Circular Hough Transform and several feature extraction methods are implemented in the proposed system. The paper also presents a novel technique for the macula region localisation in order to detect the maculopathy. In addition to the proposed detection system, the paper highlights a novel online dataset and it presents the dataset collection, the expert diagnosis process and the advantages of our online database compared to other public eye fundus image databases for diabetic retinopathy purposes.
  2. Yap HY, Choo YH, Mohd Yusoh ZI, Khoh WH
    Brain Inform, 2021 Oct 11;8(1):21.
    PMID: 34633582 DOI: 10.1186/s40708-021-00142-4
    The study of Electroencephalogram (EEG)-based biometric has gained the attention of researchers due to the neurons' unique electrical activity representation of an individual. However, the practical application of EEG-based biometrics is not currently widespread and there are some challenges to its implementation. Nowadays, the evaluation of a biometric system is user driven. Usability is one of the concerning issues that determine the success of the system. The basic elements of the usability of a biometric system are effectiveness, efficiency and user satisfaction. Apart from the mandatory consideration of the biometric system's performance, users also need an easy-to-use and easy-to-learn authentication system. Thus, to satisfy these user requirements, this paper proposes a reasonable acquisition period and employs a consumer-grade EEG device to authenticate an individual to identify the performances of two acquisition protocols: eyes-closed (EC) and visual stimulation. A self-collected database of eight subjects was utilized in the analysis. The recording process was divided into two sessions, which were the morning and afternoon sessions. In each session, the subject was requested to perform two different tasks: EC and visual stimulation. The pairwise correlation of the preprocessed EEG signals of each electrode channel was determined and a feature vector was formed. Support vector machine (SVM) was then used for classification purposes. In the performance analysis, promising results were obtained, where EC protocol achieved an accuracy performance of 83.70-96.42% while visual stimulation protocol attained an accuracy performance of 87.64-99.06%. These results have demonstrated the feasibility and reliability of our acquisition protocols with consumer-grade EEG devices.
  3. Parvar H, Sculthorpe-Petley L, Satel J, Boshra R, D'Arcy RC, Trappenberg TP
    Brain Inform, 2015 Mar;2(1):1-12.
    PMID: 27747499
    Event-related potentials (ERPs) are tiny electrical brain responses in the human electroencephalogram that are typically not detectable until they are isolated by a process of signal averaging. Owing to the extremely smallsize of ERP components (ranging from less than 1 μV to tens of μV), compared to background brain rhythms, statistical analyses of ERPs are predominantly carried out in groups of subjects. This limitation is a barrier to the translation of ERP-based neuroscience to applications such as medical diagnostics. We show here that support vector machines (SVMs) are a useful method to detect ERP components in individual subjects with a small set of electrodes and a small number of trials for a mismatch negativity (MMN) ERP component. Such a reduced experiment setup is important for clinical applications. One hundred healthy individuals were presented with an auditory pattern containing pattern-violating deviants to evoke the MMN. Two-class SVMs were then trained to classify averaged ERP waveforms in response to the standard tone (tones that match the pattern) and deviant tone stimuli (tones that violate the pattern). The influence of kernel type, number of epochs, electrode selection, and temporal window size in the averaged waveform were explored. When using all electrodes, averages of all available epochs, and a temporal window from 0 to 900-ms post-stimulus, a linear SVM achieved 94.5 % accuracy. Further analyses using SVMs trained with narrower, sliding temporal windows confirmed the sensitivity of the SVM to data in the latency range associated with the MMN.
  4. Chung J, Teo J
    Brain Inform, 2023 Jan 03;10(1):1.
    PMID: 36595134 DOI: 10.1186/s40708-022-00180-6
    Early prediction of mental health issues among individuals is paramount for early diagnosis and treatment by mental health professionals. One of the promising approaches to achieving fully automated computer-based approaches for predicting mental health problems is via machine learning. As such, this study aims to empirically evaluate several popular machine learning algorithms in classifying and predicting mental health problems based on a given data set, both from a single classifier approach as well as an ensemble machine learning approach. The data set contains responses to a survey questionnaire that was conducted by Open Sourcing Mental Illness (OSMI). Machine learning algorithms investigated in this study include Logistic Regression, Gradient Boosting, Neural Networks, K-Nearest Neighbours, and Support Vector Machine, as well as an ensemble approach using these algorithms. Comparisons were also made against more recent machine learning approaches, namely Extreme Gradient Boosting and Deep Neural Networks. Overall, Gradient Boosting achieved the highest overall accuracy of 88.80% followed by Neural Networks with 88.00%. This was followed by Extreme Gradient Boosting and Deep Neural Networks at 87.20% and 86.40%, respectively. The ensemble classifier achieved 85.60% while the remaining classifiers achieved between 82.40 and 84.00%. The findings indicate that Gradient Boosting provided the highest classification accuracy for this particular mental health bi-classification prediction task. In general, it was also demonstrated that the prediction results produced by all of the machine learning approaches studied here were able to achieve more than 80% accuracy, thereby indicating a highly promising approach for mental health professionals toward automated clinical diagnosis.
  5. Liew SH, Choo YH, Low YF, Nor Rashid F'
    Brain Inform, 2023 Aug 05;10(1):21.
    PMID: 37542531 DOI: 10.1186/s40708-023-00200-z
    This paper aims to design distraction descriptor, elicited through the object variation, to refine the granular knowledge incrementally, using the proposed probability-based incremental update strategy in Incremental Fuzzy-Rough Nearest Neighbour (IncFRNN) technique. Most of the brainprint authentication models were tested in well-controlled environments to minimize the influence of ambient disturbance on the EEG signals. These settings significantly contradict the real-world situations. Thus, making use of the distraction is wiser than eliminating it. The proposed probability-based incremental update strategy is benchmarked with the ground truth (actual class) incremental update strategy. Besides, the proposed technique is also benchmarked with First-In-First-Out (FIFO) incremental update strategy in K-Nearest Neighbour (KNN). The experimental results have shown equivalence discriminatory performance in both high distraction and quiet conditions. This has proven that the proposed distraction descriptor is able to utilize the unique EEG response towards ambient distraction to complement person authentication modelling in uncontrolled environment. The proposed probability-based IncFRNN technique has significantly outperformed the KNN technique for both with and without defining the window size threshold. Nevertheless, its performance is slightly worse than the actual class incremental update strategy since the ground truth represents the gold standard. In overall, this study demonstrated a more practical brainprint authentication model with the proposed distraction descriptor and the probability-based incremental update strategy. However, the EEG distraction descriptor may vary due to intersession variability. Future research may focus on the intersession variability to enhance the robustness of the brainprint authentication model.
  6. Yap HY, Choo YH, Mohd Yusoh ZI, Khoh WH
    Brain Inform, 2023 Aug 03;10(1):19.
    PMID: 37535168 DOI: 10.1186/s40708-023-00198-4
    Electroencephalogram(EEG)-based authentication has received increasing attention from researchers as they believe it could serve as an alternative to more conventional personal authentication methods. Unfortunately, EEG signals are non-stationary and could be easily contaminated by noise and artifacts. Therefore, further processing of data analysis is needed to retrieve useful information. Various machine learning approaches have been proposed and implemented in the EEG-based domain, with deep learning being the most current trend. However, retaining the performance of a deep learning model requires substantial computational effort and a vast amount of data, especially when the models go deeper to generate consistent results. Deep learning models trained with small data sets from scratch may experience an overfitting issue. Transfer learning becomes an alternative solution. It is a technique to recognize and apply the knowledge and skills learned from the previous tasks to a new domain with limited training data. This study attempts to explore the applicability of transferring various pre-trained models' knowledge to the EEG-based authentication domain. A self-collected database that consists of 30 subjects was utilized in the analysis. The database enrolment is divided into two sessions, with each session producing two sets of EEG recording data. The frequency spectrums of the preprocessed EEG signals are extracted and fed into the pre-trained models as the input data. Three experimental tests are carried out and the best performance is reported with accuracy in the range of 99.1-99.9%. The acquired results demonstrate the efficiency of transfer learning in authenticating an individual in this domain.
  7. Bhatt P, Sethi A, Tasgaonkar V, Shroff J, Pendharkar I, Desai A, et al.
    Brain Inform, 2023 Jul 31;10(1):18.
    PMID: 37524933 DOI: 10.1186/s40708-023-00196-6
    Human behaviour reflects cognitive abilities. Human cognition is fundamentally linked to the different experiences or characteristics of consciousness/emotions, such as joy, grief, anger, etc., which assists in effective communication with others. Detection and differentiation between thoughts, feelings, and behaviours are paramount in learning to control our emotions and respond more effectively in stressful circumstances. The ability to perceive, analyse, process, interpret, remember, and retrieve information while making judgments to respond correctly is referred to as Cognitive Behavior. After making a significant mark in emotion analysis, deception detection is one of the key areas to connect human behaviour, mainly in the forensic domain. Detection of lies, deception, malicious intent, abnormal behaviour, emotions, stress, etc., have significant roles in advanced stages of behavioral science. Artificial Intelligence and Machine learning (AI/ML) has helped a great deal in pattern recognition, data extraction and analysis, and interpretations. The goal of using AI and ML in behavioral sciences is to infer human behaviour, mainly for mental health or forensic investigations. The presented work provides an extensive review of the research on cognitive behaviour analysis. A parametric study is presented based on different physical characteristics, emotional behaviours, data collection sensing mechanisms, unimodal and multimodal datasets, modelling AI/ML methods, challenges, and future research directions.
  8. Jing C, Kuai H, Matsumoto H, Yamaguchi T, Liao IY, Wang S
    Brain Inform, 2024 Jan 08;11(1):1.
    PMID: 38190053 DOI: 10.1186/s40708-023-00216-5
    Functional magnetic resonance imaging (fMRI) provides insights into complex patterns of brain functional changes, making it a valuable tool for exploring addiction-related brain connectivity. However, effectively extracting addiction-related brain connectivity from fMRI data remains challenging due to the intricate and non-linear nature of brain connections. Therefore, this paper proposed the Graph Diffusion Reconstruction Network (GDRN), a novel framework designed to capture addiction-related brain connectivity from fMRI data acquired from addicted rats. The proposed GDRN incorporates a diffusion reconstruction module that effectively maintains the unity of data distribution by reconstructing the training samples, thereby enhancing the model's ability to reconstruct nicotine addiction-related brain networks. Experimental evaluations conducted on a nicotine addiction rat dataset demonstrate that the proposed GDRN effectively explores nicotine addiction-related brain connectivity. The findings suggest that the GDRN holds promise for uncovering and understanding the complex neural mechanisms underlying addiction using fMRI data.
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