Displaying publications 1 - 20 of 36 in total

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  1. Tong CV, Hussein Z, Noor NM, Mohamad M, Ng WF
    QJM, 2015 Jan;108(1):49-50.
    PMID: 25099611 DOI: 10.1093/qjmed/hcu166
  2. Khositseth S, Bruce LJ, Walsh SB, Bawazir WM, Ogle GD, Unwin RJ, et al.
    QJM, 2012 Sep;105(9):861-77.
    PMID: 22919024 DOI: 10.1093/qjmed/hcs139
    Distal renal tubular acidosis (dRTA) caused by mutations of the SLC4A1 gene encoding the erythroid and kidney isoforms of anion exchanger 1 (AE1 or band 3) has a high prevalence in some tropical countries, particularly Thailand, Malaysia, the Philippines and Papua New Guinea (PNG). Here the disease is almost invariably recessive and can result from either homozygous or compound heterozygous SLC4A1 mutations.
  3. Ong HT
    QJM, 2005 Aug;98(8):599-614.
    PMID: 16006501
    The landmark HMG-CoA reductase inhibitor (statin) studies have practical lessons for clinicans. The 4S trial established the importance of treating the hypercholesterolaemic patient with cardiovascular heart disease. Next, WOSCOPS showed the benefit of treating healthy, high-risk hypercholesterolaemic men. CARE, a secondary prevention trial, showed the benefit of treating patients with cholesterol levels within normal limits. This was confirmed by the LIPID trial, another secondary prevention study, which enrolled patients with cholesterol levels 155-271 mg/dl (4-7 mmol/l). The importance of treating patients with established ischaemic heart disease, and those at high risk of developing heart disease, regardless of cholesterol level, was being realized. In the MIRACL trial, hypocholesterolaemic therapy was useful in the setting of an acute coronary syndrome, while the AVERT study showed that aggressive statin therapy is as good as angioplasty in reducing ischaemic events in patients with stable angina. By showing the value of fluvastatin after percutaneous intervention, LIPS confirmed that benefit is a class action of the statins. The HPS randomized over 20 000 patients, and showed beyond doubt the value of statins in reducing cardiovascular events in the high-risk patient. Although PROSPER showed benefit in treating the elderly patients above 70 years, statin therapy in this trial was associated with an increase in cancer incidence. The comparative statin trials, PROVE-IT, REVERSAL, Phase Z of the A to Z, ALLIANCE and TNT, all showed that high-dose statins will better reduce cardiovascular events in the high-risk patient, although the adverse effects of therapy will also be increased. ALLHAT-LLT, ASCOT-LLA and CARDS showed that for statin therapy to demonstrate a significant benefit, hypertensive or diabetic patients must be at sufficiently high risk of cardiovascular events. The emphasis is now on the risk level for developing cardiovascular events, and treatment should target the high-risk group and not the lipid level of the patient. No therapy is free of adverse effect. Treatment of those most at risk will bring the most benefit; treatment of those not at high risk of cardiovascular disease may expose patients who would not benefit much from therapy to its adverse effects.
  4. Balasingam S, Azman RR, Nazri M
    QJM, 2016 Feb;109(2):121-2.
    PMID: 26101228 DOI: 10.1093/qjmed/hcv121
  5. Paton NI, Cheong IK, Kong NC, Segasothy M
    QJM, 1996 Jul;89(7):531-8.
    PMID: 8759494 DOI: 10.1093/qjmed/89.7.531
    To determine the incidence, types and risk factors for infection in systemic lupus erythematosus (SLE) patients in Kuala Lumpur, Malaysia, we retrospectively reviewed the medical records of 102 patients with definite SLE attending a specialist clinic. Details of major infections (pneumonia or severe infection requiring intravenous therapy) and minor infections, and their time of onset in relation to immunosuppressive therapy and disease flares were recorded. There were 77 major and 163 minor infections during 564 patient-years of follow-up. In the month following a course of pulse methylprednisolone, the incidence of major infection was 20 times higher and the incidence of minor infection was 10 times higher than at other periods (p < 0.0001). In the month after disease flare, the incidence of major infection was 10 times higher and the incidence of minor infection six times higher than at other times (p < 0.0001). After allowing for methylprednisolone therapy and disease flares, there was no increase in the rate of infections during treatment with azathioprine, oral or intravenous cyclophosphamide. There was no effect of renal involvement on infection rate.
  6. Chaubal T, Bapat R, Wadkar P
    QJM, 2017 Aug 01;110(8):527.
    PMID: 28453856 DOI: 10.1093/qjmed/hcx090
  7. Tan SH, Prepageran N
    QJM, 2018 Oct 01;111(10):743.
    PMID: 29660085 DOI: 10.1093/qjmed/hcy084
  8. Kanneppady SK, Kanneppady SS, Chaubal T, Bapat R
    QJM, 2018 Oct 01;111(10):753-754.
    PMID: 29788120 DOI: 10.1093/qjmed/hcy100
  9. Cheo SW, Low QJ
    QJM, 2019 Mar 01;112(3):221-222.
    PMID: 30247725 DOI: 10.1093/qjmed/hcy210
  10. Cheo SW, Low QJ, Mow WC, Chia YK
    QJM, 2019 May 01;112(5):381-382.
    PMID: 30517761 DOI: 10.1093/qjmed/hcy284
  11. Chaubal T, Bapat R, Wadkar P
    QJM, 2017 Dec 01;110(12):841-842.
    PMID: 29025105 DOI: 10.1093/qjmed/hcx164
  12. Noh MSFM, Rajadurai N
    QJM, 2017 Nov 01;110(11):763.
    PMID: 29025148 DOI: 10.1093/qjmed/hcx153
  13. Sadaphule R, Chaubal T, Bapat R, Wadkar P
    QJM, 2017 Oct 01;110(10):685.
    PMID: 29087529 DOI: 10.1093/qjmed/hcx132
  14. Md Noh MSF, Abdul Rashid AM
    QJM, 2018 May 01;111(5):343.
    PMID: 29228291 DOI: 10.1093/qjmed/hcx240
  15. Pallister RA
    QJM, 1947;16(2):47-60.
    DOI: 10.1093/oxfordjournals.qjmed.a066486
    1. Three series of cases of oedema in an internment camp are described.
    2. The first series of cases consisted of those diagnosed as beriberi. They were much less common than cases of oedema from other nutritional causes. Most of the beriberi cases occurred in a period when the supply of vitamin B1 was low. The other patients developed their disease while outside the camp. The clinical features are described and the diagnosis discussed.
    3. The second series of cases occurred at the same time as the beriberi, but the olinical appearances were sufficiently different from beriberi to lead to the diagnosis of nutritional oedema from some unknown cause.
    4. The third series occurred towards the end of internment and were probably due to hypoproteinaemia.
  16. Arora S, Kanneppady SK, Banavar SR, Jnanendrappa N
    QJM, 2019 Aug 01;112(8):615-616.
    PMID: 31120127 DOI: 10.1093/qjmed/hcz117
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