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  1. Bozdag M, Alafeefy AM, Altamimi AM, Vullo D, Carta F, Supuran CT
    Bioorg Med Chem, 2017 01 15;25(2):677-683.
    PMID: 27939347 DOI: 10.1016/j.bmc.2016.11.039
    Herein we report for the first time a series of 2-benzamido-N-(2-oxo-4-(methyl/trifluoromethyl)-2H-chromen-7-yl) benzamide 3a-f and substituted quinazolin-4(3H)-ones and 2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxides (5, 6, 8 and 10a-c) as selective inhibitors of the tumor associated hCA IX and XII isoforms. Among the compounds reported the trifluoromethyl derivative 3d resulted the most potent against these CA isoforms with KIs of 10.9 and 6.7nM.
    Matched MeSH terms: Bicyclo Compounds, Heterocyclic/pharmacology*
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