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  1. Fulltext Pyogenic granuloma like kaposi sarcoma: Case report and review of literature
    Mardiana Abdul Aziz, Effat Omar
    Journal of Clinical and Health Sciences, 2020;5(2):66-74.
    MyJurnal
    Pyogenic granuloma-like Kaposi sarcoma (PGLKS) is an uncommon variant of Kaposi
    sarcoma (KS), which mimics benign pyogenic granuloma both clinically and histologically. We
    report a case of PGLKS of the toe occurring in a HIV-positive individual. It presented as a 2cm
    skin swelling of 2 weeks’ duration which was clinically felt to be a pyogenic granuloma.
    Histopathological examination revealed a polypoid atypical vascular lesion with overlying
    peripheral epidermal collarette. Spindle cell proliferation typically seen in KS was also
    identified, which was positive for human herpesvirus 8 (HHV8) by immunohistochemistry,
    confirming the diagnosis of PGLKS. Upon review of the literature, our case is the 29th case of
    PGLKS reported to date, and only the sixth in Asian population. Particular attention to
    histomorphology, and demonstration of HHV8 in lesional tissue will aid accurate diagnosis of
    this rare entity.
    Matched MeSH terms: Herpesvirus 8, Human
  2. Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa
    Ablashi D, Chatlynne L, Cooper H, Thomas D, Yadav M, Norhanom AW, et al.
    Br. J. Cancer, 1999 Nov;81(5):893-7.
    PMID: 10555764
    Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries in both the healthy and the HIV-infected populations. This correlates with the fact that hardly any AIDS-related Kaposi's sarcoma has been reported in these countries. In contrast, the African countries of Ghana, Uganda and Zambia showed high seroprevalences in both healthy and HIV-infected populations. This suggests that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity. Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres show that only 3/82 (3.7%) have antibody to HHV-8, demonstrating that there is little, if any, cross-reactivity between antibodies to these two gamma viruses.
    Matched MeSH terms: Herpesvirus 8, Human/immunology*
  3. Fulltext Human herpes virus 8 antibodies in HIV-positive patients in Surabaya, Indonesia
    Oktafiani D, Megasari NL, Fitriana E, Nasronudin, Lusida MI, Soetjipto
    Infect Dis Rep, 2020 07 07;12(Suppl 1):8746.
    PMID: 32874472 DOI: 10.4081/idr.2020.8746
    Background: Human herpesvirus 8 (HHV-8) infection is etiologically related to Kaposi's sarcoma. Antibodies directed against HHV-8 can be detected in 80-95% of HIV-seropositive patients with KS. HHV-8 serological tests have been done in several countries in Southeast Asia such as Malaysia, and Thailand however no serological data is available in Indonesia. This study was to examine the presence of HHV- 8 antibodies in HIV-positive patients in Surabaya, Indonesia.

    Material and methods: Ninety-one serum samples were collected from HIVpositive patients in Surabaya, Indonesia. Human immunodeficiency virus-positive serum samples were collected from 10 homosexual men, 25 intravenous drug users (IVDUs) and 56 heterosexuals. Serums were then tested for the presence of HHV-8 antibody by using sandwich ELISA (Abbexa Ltd, Cambridge, UK).

    Results: The total of 91 HIV-infected were testing with antibodies to HHV-8 using enzyme-linked immunosorbent assay. Antibodies of HHV-8 were detected in 7/91 (7.7%) of the samples. According to a gender, six men (85.7%) and a women (14.3%) were positive of HHV-8 antibodies. No correlation regarding the gender and age from this study. The antibodies of HHV-8 was detected among intravenous drug users (IVDUs) men 5/7 (42.8%) and 2/7 (28.6%) from homosexual and heterosexual, respectively.

    Conclusion: This study found the presence of HHV-8 antibodies in 7.7% of patients in Surabaya, Indonesia. This finding was higher more than Southeast Asian countries. The patients with a positive result could suggest measures to prevent HHV-8 infection.

    Matched MeSH terms: Herpesvirus 8, Human
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