MyMedR

Fulltext A report of two non-AIDS associated Kaposi's sarcoma in Malaysia

Choon SE, Khoo JJ

Med J Malaysia, 1997 Dec;52(4):437-40.

Kaposi's sarcoma is an uncommon cutaneous neoplasm seen classically in elderly males of East European or Jewish extract. It has been known to be endemic in sub-Saharan Africa for many years. Numerous cases had been described in patients on long-term immunosuppressive therapy and in patients living with acquired immunodeficiency syndrome (AIDS). In spite of the increasing number of organ transplant recipients and people living with AIDS. Kaposi's sarcoma remains rare in Asia. We report two cases seen in Johor, Malaysia.

Matched MeSH terms: Sarcoma, Kaposi/etiology*; Sarcoma, Kaposi/therapy

Fulltext Kaposi's sarcoma: case report and treatment options

Tan WC, Chan LC

Med J Malaysia, 2011 Oct;66(4):383-4.

PMID: 22299569

Kaposi's sarcoma (KS) is strongly associated with Human Herpes Virus 8 (HHV8) and Human Immunodeficiency Virus infection (HIV). It was the first malignancy to be linked with Acquired Immunodeficiency Syndrome (AIDS). We report a case of Kaposi's sarcoma in a newly diagnosed retroviral homosexual patient with CD4 count of 21. He had multiple firm discrete violaceous plaques and nodules scattered over the face, scalp, hard palate, trunk and genitalia. Biopsy of a skin nodule over the trunk and a biopsy of a lesion from the gastric mucosa confirmed Kaposi's sarcoma. He was started on Highly Active Antiretroviral Therapy (HAART) and cryotherapy (liquid nitrogen) was given for the lesions over the skin. He responded well to treatment. Liquid nitrogen is a useful adjuvant treatment for Kaposi's sarcoma.

Matched MeSH terms: Sarcoma, Kaposi/therapy*

Kaposi's sarcoma following long term steroid therapy

Akmal SN, Wahab YA

Malays J Pathol, 1989 Aug;11:65-8.

PMID: 2633002

An 18-year-old Malay lady was treated with high dose steroids for three and a half years for idiopathic thrombocytopaenic purpura. At 21 years, after a series of relapses, a splenectomy was carried out. In addition, two nodules at the hilum of the spleen were also removed. Histological examination of these nodules revealed features of Kaposi's sarcoma. Kaposi's sarcoma resulting from immunosuppression by corticosteroids is rare. Our patient is the first such case reported in Malaysia.

Matched MeSH terms: Sarcoma, Kaposi/etiology*

Total resolution of ocular Kaposi sarcoma with different treatment approaches - a case series and review of literature

Yeak J, Iqbal T, Zahari M, Ismail F

Int J STD AIDS, 2019 07;30(8):802-809.

PMID: 31046617 DOI: 10.1177/0956462418825353

Matched MeSH terms: Sarcoma, Kaposi/complications; Sarcoma, Kaposi/diagnosis*; Sarcoma, Kaposi/drug therapy; Sarcoma, Kaposi/radiotherapy

Fulltext Viruses and cancer

Yasmin AM

Med J Malaysia, 1997 Jun;52(2):105-7.

PMID: 10968066

Matched MeSH terms: Sarcoma, Kaposi/complications

Fulltext Pyogenic granuloma like kaposi sarcoma: Case report and review of literature

Mardiana Abdul Aziz, Effat Omar

Journal of Clinical and Health Sciences, 2020;5(2):66-74.

MyJurnal

Pyogenic granuloma-like Kaposi sarcoma (PGLKS) is an uncommon variant of Kaposi
sarcoma (KS), which mimics benign pyogenic granuloma both clinically and histologically. We
report a case of PGLKS of the toe occurring in a HIV-positive individual. It presented as a 2cm
skin swelling of 2 weeks’ duration which was clinically felt to be a pyogenic granuloma.
Histopathological examination revealed a polypoid atypical vascular lesion with overlying
peripheral epidermal collarette. Spindle cell proliferation typically seen in KS was also
identified, which was positive for human herpesvirus 8 (HHV8) by immunohistochemistry,
confirming the diagnosis of PGLKS. Upon review of the literature, our case is the 29th case of
PGLKS reported to date, and only the sixth in Asian population. Particular attention to
histomorphology, and demonstration of HHV8 in lesional tissue will aid accurate diagnosis of
this rare entity.

Matched MeSH terms: Sarcoma, Kaposi

Fulltext Disseminated AIDS-related Kaposi's sarcoma

Tang ASO, Teh YC, Chea CY, Yeo ST, Chua HH

Oxf Med Case Reports, 2018 Dec;2018(12):omy107.

PMID: 30487992 DOI: 10.1093/omcr/omy107

We present a case of disseminated Kaposi's sarcoma with both cutaneous and extracutaneous involvement in an HIV-infected patient with a relatively high CD4 count of 369 cell/mm3. He developed chronic diarrhea, constitutional symptoms, worsening bilateral pleural effusion with respiratory distress, and progression of skin lesions distributed over his chest and extremities. The temporal relationship between rapid clinical progression and initiation of HAART suggested the possibility of Kaposi's sarcoma-associated immune reconstitution inflammatory syndrome, which eventually resulted in the death of this patient.

Matched MeSH terms: Sarcoma, Kaposi

Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa

Ablashi D, Chatlynne L, Cooper H, Thomas D, Yadav M, Norhanom AW, et al.

Br. J. Cancer, 1999 Nov;81(5):893-7.

PMID: 10555764

Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries in both the healthy and the HIV-infected populations. This correlates with the fact that hardly any AIDS-related Kaposi's sarcoma has been reported in these countries. In contrast, the African countries of Ghana, Uganda and Zambia showed high seroprevalences in both healthy and HIV-infected populations. This suggests that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity. Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres show that only 3/82 (3.7%) have antibody to HHV-8, demonstrating that there is little, if any, cross-reactivity between antibodies to these two gamma viruses.

Matched MeSH terms: Sarcoma, Kaposi/epidemiology*

Characteristics of skin cancers among adult patients in an urban Malaysian population

Han WH, Yong SS, Tan LL, Toh YF, Chew MF, Pailoor J, et al.

Australas J Dermatol, 2019 Nov;60(4):e327-e329.

PMID: 31222718 DOI: 10.1111/ajd.13106

There has been a rising incidence of skin cancers among Asians in recent years. We present a retrospective analysis of 106 skin cancers and analysed the demography, clinical subtypes of skin cancers and surgical techniques used for skin cancer treatment. In our population, skin cancers were most frequently basal cell carcinomas and diagnosed among ethnic Chinese patients.

Matched MeSH terms: Sarcoma, Kaposi/epidemiology

Fulltext Human herpes virus 8 antibodies in HIV-positive patients in Surabaya, Indonesia

Oktafiani D, Megasari NL, Fitriana E, Nasronudin, Lusida MI, Soetjipto

Infect Dis Rep, 2020 07 07;12(Suppl 1):8746.

PMID: 32874472 DOI: 10.4081/idr.2020.8746

Background: Human herpesvirus 8 (HHV-8) infection is etiologically related to Kaposi's sarcoma. Antibodies directed against HHV-8 can be detected in 80-95% of HIV-seropositive patients with KS. HHV-8 serological tests have been done in several countries in Southeast Asia such as Malaysia, and Thailand however no serological data is available in Indonesia. This study was to examine the presence of HHV- 8 antibodies in HIV-positive patients in Surabaya, Indonesia.

Material and methods: Ninety-one serum samples were collected from HIVpositive patients in Surabaya, Indonesia. Human immunodeficiency virus-positive serum samples were collected from 10 homosexual men, 25 intravenous drug users (IVDUs) and 56 heterosexuals. Serums were then tested for the presence of HHV-8 antibody by using sandwich ELISA (Abbexa Ltd, Cambridge, UK).

Results: The total of 91 HIV-infected were testing with antibodies to HHV-8 using enzyme-linked immunosorbent assay. Antibodies of HHV-8 were detected in 7/91 (7.7%) of the samples. According to a gender, six men (85.7%) and a women (14.3%) were positive of HHV-8 antibodies. No correlation regarding the gender and age from this study. The antibodies of HHV-8 was detected among intravenous drug users (IVDUs) men 5/7 (42.8%) and 2/7 (28.6%) from homosexual and heterosexual, respectively.

Conclusion: This study found the presence of HHV-8 antibodies in 7.7% of patients in Surabaya, Indonesia. This finding was higher more than Southeast Asian countries. The patients with a positive result could suggest measures to prevent HHV-8 infection.

Matched MeSH terms: Sarcoma, Kaposi

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