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  1. Galloway DJ
    J Laryngol Otol, 1903;18:64-70.
    DOI: 10.1017/S1755146300172403
    Matched MeSH terms: Otomycosis
  2. Khoo JH, Zainon IH, Johari HH, Sachlin IS
    J Int Adv Otol, 2024 Nov 25;20(6):536-539.
    PMID: 39660747 DOI: 10.5152/iao.2024.231331
    BACKGROUND: Paecilomyces spp. are thermo-tolerant fungi found in decaying vegetables and soil. They can cause ocular, cutaneous, and miscellaneous infections. In otorhinolaryngology, most infections occur in the paranasal sinuses, while otological infection is uncommon.

    METHODS: We report a case of 41-year-old diabetic, male army officer with warm, fluctuant left temporal swelling and reduced hearing. Otoscopy revealed an edematous external auditory canal (EAC) with posterior wall sagging and bulging tympanic membrane. Computed tomography revealed subperiosteal temporal abscess extending intracranially. The pus was drained surgically via an otological and a neurosurgical approach, and pus sent for culture grew paecilomyces. He showed clinical improvement after receiving oral antifungal treatment postoperatively. Retrospectively, his occupation as an army officer and his diabetic immunocompromised state may have predisposed him to the infection.

    RESULTS: Paecilomyces middle ear infection leading to intracranial involvement of such magnitude is yet to be reported, and we showcase its successful management through a combined surgical neuro-otology approach and oral antifungal therapy. Fungal ear infections can lead to severe extracranial and intracranial complications if inadequately treated. Differentiating it from cholesteatoma also presents a diagnostic challenge clinically and radiologically. While both can lead to intracranial complications, our patient's brief history and lack of prior ear symptoms contrast with that of cholesteatoma.

    CONCLUSION: The rarity of neuro-otological paecilomyces infections emphasizes the need for awareness and early identification. It is vital to recognize such infections, and prompt surgical management with appropriate antifungal drugs is warranted to prevent disastrous outcomes.

    Matched MeSH terms: Otomycosis/diagnosis; Otomycosis/drug therapy; Otomycosis/microbiology
  3. Puvan Arul Arumugam, Irfan Mohamad, Rosdan Salim, Zeehaida Mohamed
    MyJurnal
    Azadirachta indica (neem) has been used for a long time in agricultural and alternative medicine. Neem
    had been proved effective against certain fungi that could infect human body. This pilot study aims to
    demonstrate the antifungal effect of Malaysian neem leaf extracts on the pathogenic fungi in otomycosis,
    Aspergillus niger and Candida albicans. This is a laboratory-controlled prospective study conducted at
    Universiti Sains Malaysia. The powder form of Malaysian neem leaf was prepared. Ethanol and aqueous
    extracts of the neem leaf was diluted with sterile water to establish five different concentrations of 50 g/
    ml, 25 g/ml, 12.5 g/ml, 6.25 g/ml and 3.125g/ml. The extract was tested on Sabouraud Dextrose Agar
    suspended with Candida albicans and Aspergillus niger respectively. Well diffusion method was used
    and zone of inhibition was measured. Growth of the fungi was inhibited in both alcohol and aqueous
    extract concentrations. The minimum inhibitory concentration (MIC) of Malaysian neem aqueous extract
    against Candida albicans was 11.91 g/ml, neem ethanol extract against Candida albicans was 5.16 g/
    ml, neem aqueous extract against Aspergillus niger was 7.73 g/ml and neem ethanol extract against
    Aspergillus niger was 9.25 g/ml. Statistical analysis showed that the antifungal activity of Candida
    albicans is better in alcohol neem than aqueous extract (p
    Matched MeSH terms: Otomycosis
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