Displaying all 9 publications

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  1. Siong LY, Sing YC, Wan OY
    Mod Med Asia, 1976 Nov;12(11):6-8.
    PMID: 827682
    Matched MeSH terms: Rh-Hr Blood-Group System*
  2. Kuah KB, Lim CS
    Med J Malaysia, 1974 Jun;28(4):273-5.
    PMID: 4278822
    Matched MeSH terms: Rh-Hr Blood-Group System/analysis*
  3. Mendoza-Barker MG
    Med J Malaya, 1965 Jun;19(4):306-10.
    PMID: 4220857
    Matched MeSH terms: Rh-Hr Blood-Group System*
  4. Banerjee B, Saha N
    Med J Malaya, 1969 Sep;24(1):41-4.
    PMID: 4243842
    Matched MeSH terms: Rh-Hr Blood-Group System*
  5. Flatt JF, Musa RH, Ayob Y, Hassan A, Asidin N, Yahya NM, et al.
    Br J Haematol, 2012 Jul;158(2):262-273.
    PMID: 22571328 DOI: 10.1111/j.1365-2141.2012.09149.x
    Red cells with the D-- phenotype do not express the RHCE protein because of mutations in both alleles of the RHCE gene. At present, little is known of the effect this has on the normal function of erythrocytes. In this study a group of five families belonging to a nomadic tribe in Malaysia were identified as carriers of the D-- haplotype. Analysis of homozygous individuals' genomic DNA showed two separate novel mutations. In four of the families, RHCE exons 1, 9 and 10 were present, while the 5th family possessed RHCE exons 1-3 and 10. Analysis of cDNA revealed hybrid transcripts, suggesting a gene conversion event with RHD, consistent with previously reported D-- mutations. Immunoblotting analysis of D-- erythrocyte membrane proteins found that Rh-associated glycoprotein (RHAG) migrates with altered electrophoretic mobility on sodium dodecyl sulphate polyacrylamide gel electrophoresis, consistent with increased glycosylation. Total amounts of Rh polypeptide in D-- membranes were comparable with controls, indicating that the exalted D antigen displayed by D-- red cells may be associated with altered surface epitope presentation. The adhesion molecules CD44 and CD47 are significantly reduced in D--. Together these results suggest that absence of RHCE polypeptide alters the structure and packing of the band 3/Rh macrocomplex.
    Matched MeSH terms: Rh-Hr Blood-Group System/blood; Rh-Hr Blood-Group System/genetics*; Rh-Hr Blood-Group System/metabolism
  6. Dielievska V, Korzh M, Leontieva F, Ashukina N, Borzova O
    Arch Razi Inst, 2020 06;75(2):257-265.
    PMID: 32621457 DOI: 10.22092/ari.2020.341761.1439
    This study investigated a person with an AB0 discrepancy. Her blood group initially typed at the birth as AB Rh+ (positive); however, it was B Rh+ (positive) or Rh- (negative) when she was in her teens. At room temperature, her erythrocytes were agglutinated by anti-B, and the agglutination was significantly weaker at 37 ºC. As a result, her erythrocytes did not absorb anti-B but anti-A. Furthermore, her erythrocytes were agglutinated by anti-A at 37 ºC with signs of hemolysis in the presence of complement. The unwashed erythrocytes were also agglutinated in an antiglobulin test by polyclonal anti-A at 37 ºC and by heated polyclonal anti-A and anti-A MAB 2-8 at room temperature. Moreover, her serum agglutinated A erythrocytes at room temperature with less activity at 37 ºC; however, it agglutinated B erythrocytes at 37 ºC. The ability of the erythrocytes of this person to absorb anti-A came along with the agglutination of her erythrocytes at 37 ºC by polyclonal serum and decreased activity of the serum to agglutinate A erythrocytes at 37 ºC, compared to room temperature. The absence of anti-B absorbance by the person’s erythrocytes was accompanied by the presence of anti-B in the serum, which was active at 37 ºC. The incubation of the person’s serum with 0 erythrocytes induced the ability of erythrocytes to absorb anti-A and to be hemolyzed by anti-A in the presence of complement in accordance with the person’s characteristics of erythrocytes. The reaction of absorption and agglutination at room temperature and 37 ºC by heated serum with the use of complement may help to reveal both weak A and B antigens and anti-A and anti-B antibodies while AB0 blood typing.
    Matched MeSH terms: Rh-Hr Blood-Group System/immunology*
  7. Teng YS, Tan SG
    Jinrui Idengaku Zasshi, 1979 Mar;24(1):1-8.
    PMID: 110968
    Matched MeSH terms: Rh-Hr Blood-Group System
  8. Hawkins BR, Simons MJ, Goh EH, Chia KB, Shanmugaratnam K
    Int J Cancer, 1974 Jan 15;13(1):116-21.
    PMID: 4206461 DOI: 10.1002/ijc.2910130113
    Matched MeSH terms: Rh-Hr Blood-Group System
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