Friend™ feminine wipes, disinfectant impregnanted fibre Nssues meant for the maintenance of female hygiene, was evaluated for its effect on sperm viability in-vitro and found to be spermicidal. These feminine wipes are therefore not recommended for use at coitus in couples who are planning
pregnancies. Although the wipes were found to have spermicidal properties they are not recommended for the purpose of contraception
A local study, a part of a multinational and multicenter study on the efficacy and safety of Buserelin was carried out for the treatment ofpelvic endometriosis using a standard protocol. 20 women diagnosed to have moderate to severe endometriosis by laparoscopy were recruited. The women were given 900 micrograms Buserelin acetate daily by intranasal spray for a fixed period of 6 months. 8aseline hormona/and biochemical parameters were taken prior to treatment and the parameters were repeated during each follow-up at weekly and monthly intervals. In addition. changes in
symptoms were monitored. A second look laparoscopy was performed at completion of therapy and patients were followed up for a further 6 months. There was 100 percent suppression of oestradiol levels dUring the 6 months treatment period. An improvement of implants according to AFS classification occured in all patients. One patient discontinued because of side effects. Restoration of cycles after completion of therapy occured within 7 weeks. There were 7 pregnancies (64%) in the first 6 months after treatment for those wanting pregnancies. During therapy, dysmenorrhoea, pelvic pain and dyspareunia improved ,considerably. Buserelin was proven to be effective in the management of pelvic endometriosis a.~d is well tolerated and safe.
In order to examine whether erythrocyte membrane handling of sodium is influenced by factors other than hypertension, measurements of red cell sodium transport were studied in one hundred normotensive volunteers. Erythrocyte sodium content was found to increase with increasing age, body weight and mean arterial pressure (MAP). It is also significantly correlated with age, body weight and MAP. Total sodium efflux was found to be reduced and negatively correlated with age and body weight. A reduction in ouabain-sensitive sodium efflux was also observed with increasing age and body weight. In males, the rate of ouabain-sensitive sodium efflux is higher than in females. Race was found to have no effect on erythrocyte electrolyte content and cationic flux rates of subjects. These data suggest that when studies in hypertension are going to be carried out, control subjects carefully matched for age, body weight and sex should be used if confounding results are not to be obtained.
MeSH terms: Adult; Aging/blood; Aging/physiology*; Blood Pressure*; Body Weight*; Erythrocytes/metabolism; Female; Humans; Male; Middle Aged; Potassium/metabolism; Sex Characteristics*; Sodium Channels/metabolism*; Continental Population Groups*
Clinical, radiological and histological characteristics of the peripheral ameloblastoma are briefly outlined. A case found occurring in the palate and presenting with atypical histological features is reported. The differential diagnosis of this lesion, its treatment and histogenesis are discussed.
The sophisticated cities, the ancient culture, splendid hotels, wonderful beaches, the variety of food, the beautiful people, the predictable climate and above all the smiling friendliness of the Thais make up some of the exotic attractions extolled by Thailand's tourist industry. For the last 8 years, through the good offices of British Council, several British academics have appreciated all that but have also had the privilege of working alongside Thai colleagues in a much more down-to-earth mode. In 1980 the Thai Government decided that a dental faculty with a target output of 40 DDS graduates per annum should be set up at the Prince of Songkhla University at Hadyai, a town of some 100,000 inhabitants about 1000 km south of Bangkok near the Malaysian border. The university itself is modern, situated on a splendid campus and has a well-established medical faculty. At that time, there were, in Thailand, four dental faculties: two in Bangkok, one in Chiang Mai and one at Khon Kaen. Prince of Songkhla was to be the fifth.
Atherosclerosis impairs endothelium-dependent relaxation of large conduit arteries. Because coronary resistance vessels are spared from the development of overt atherosclerosis, endothelium-dependent responses were examined in these vascular segments. Malaysian cynomolgus monkeys (n = 6) were made atherosclerotic by being fed a 0.7% cholesterol diet for 18 months. Control monkeys (n = 6) were fed a standard diet. Coronary microvessels (122-220 microns) were studied in a pressurized (20 mm Hg), no-flow state using a video-imaging apparatus. Relaxations of microvessels, preconstricted with the thromboxane analogue U46619, were determined in response to acetylcholine, bradykinin, the calcium ionophore A23187, adenosine, and sodium nitroprusside. Microvascular relaxations to bradykinin and A23187 were reduced in atherosclerotic monkeys compared with controls, whereas acetylcholine produced additional contraction in atherosclerotic monkeys. Responses of preconstricted microvessels to adenosine and sodium nitroprusside were identical in atherosclerotic and control animals. Indomethacin did not alter responses in control or atherosclerotic animals. Histologic examination revealed neither intimal thickening nor plaque formation in microvessels of this size class despite marked changes in conduit arteries. Electron microscopy showed minor alterations of endothelial cell morphology in microvessels of atherosclerotic animals. In conclusion, long-term hypercholesterolemia markedly impairs endothelium-dependent vascular relaxation in the coronary microcirculation where overt atherosclerosis does not develop. These changes in endothelial cell function may significantly alter regulation of myocardial perfusion by neurohumoral stimuli.
471 ovarian tumours were available for study from 1980 to 1987. Epidemiological breakdown by race, age and the histological type of the tumours was obtained. The diagnosis of the individual tumours was based on the World Health Organisation (WHO) histological classification of ovarian tumours. There were 324 (68.8%) benigh and 147 (31.2%) malignant tumours. 253 (53.7%) of the tumours were seen in the Malays. The third decade was the peak age for the benigh tumours, and for the malignant tumours, the fourth and fifth decades. 138 (42.6%) of the benign ovarian tumours were cystic teratomas and 45 (30.6%) of the malignant tumours were cystadenocarcinoma.
A retrospective analysis of 49 patients with 55 liver abscesses evaluated by diagnostic ultrasonography was made. The sonographic appearances were varied and non-specific. 96% of the abscesses were in the right lobe of the liver. Sonographic features which were frequently observed include (a) predominantly hypoechoic internal echotexture (64%) (b) distal sonic enhancement (98%) (c) well-defined margin with an abrupt transition between normal liver parenchyma and lesion (96%) and (d) absence of wall echoes (89%). A combination of these features has considerable diagnostic value. Distal sonic enhancement is of particular diagnostic importance. In equivocal cases the diagnosis can be quickly determined by percutaneous needle aspiration under ultrasound guidance.
Stool samples obtained from 120 Malay children, aged below 6 years, in Mukim Ijok, Kuala Selangor, were tested. Enteric pathogens were found in 7.5% of specimens. Enteropathogenic Escherichia coli (EPEC) was the most common enteric pathogen isolated (6.7%) followed by Salmonella spp (0.83%). The rate of isolation was independent of age and sex.
MeSH terms: Aged; Child; Escherichia coli; Malaysia; Salmonella; Sex