Browse publications by year: 2010

  1. Fulltext Dichlorido{2-morpholino-N-[1-(2-pyrid-yl)ethyl-idene]ethanamine-κN,N',N''}manganese(II)
    Ikmal Hisham NA, Suleiman Gwaram N, Khaledi H, Mohd Ali H
    Acta Crystallogr Sect E Struct Rep Online, 2010;67(Pt 1):m41.
    PMID: 21522562 DOI: 10.1107/S1600536810050221
    In the title compound, [MnCl(2)(C(13)H(19)N(3)O)], the Mn(II) ion is penta-coordinated in a distorted square-pyramidal geometry. The coordination environment is defined by the N,N',N''-tridentate Schiff base ligand and one Cl atom in the basal positions and one Cl atom in the apical position. In the crystal, inter-molecular C-H⋯Cl hydrogen bonds link the mol-ecules into a three-dimensional network. An intra-molecular C-H⋯Cl hydrogen bond is also observed.
  2. Fulltext Dichlorido{2-morpholino-N-[1-(2-pyrid-yl)ethyl-idene]ethanamine-κN,N',N''}zinc(II)
    Ikmal Hisham NA, Suleiman Gwaram N, Khaledi H, Mohd Ali H
    Acta Crystallogr Sect E Struct Rep Online, 2010;67(Pt 1):m55.
    PMID: 21522573 DOI: 10.1107/S1600536810050671
    In the title compound, [ZnCl(2)(C(13)H(19)N(3)O)], the Schiff base ligand acts as an N,N',N''-tridentate chelating agent, making two five-membered rings with the Zn(II) ion. The metal atom is five-coordinated by the Schiff base ligand and two Cl atoms in a distorted square-pyramidal geometry. An intra-molecular C-H⋯Cl inter-action occurs. In the crystal, adjacent mol-ecules are linked together via C-H⋯Cl hydrogen-bonding and long range C-H⋯O and C-H⋯Cl inter-actions into a three-dimensional network.
  3. Fulltext Chlorido(2-{1-[(2-morpholino-eth-yl)imino]-eth-yl}phenolato-κN,N',O)copper(II)
    Ikmal Hisham NA, Suleiman Gwaram N, Khaledi H, Mohd Ali H
    Acta Crystallogr Sect E Struct Rep Online, 2010;67(Pt 1):m57.
    PMID: 21522575 DOI: 10.1107/S1600536810051160
    In the title compound, [CuCl(C(14)H(19)N(2)O(2))], the Cu(II) ion is four-coordinated by one deprotonated N,N',O-tridentate Schiff base and one chloride ion in a distorted square-planar geometry. In the crystal, adjacent mol-ecules are linked via C-H⋯Cl and C-H⋯O inter-actions, forming infinite layers parallel to the (100) plane. The structure was determined from a non-merohedrally twined crystal [twin ratio 0.777 (3):0.223 (3)].
  4. Fulltext {2-Morpholino-N-[1-(2-pyrid-yl)ethyl-idene]ethanamine-κN,N',N''}bis-(thio-cyanato-κN)copper(II)
    Suleiman Gwaram N, Ikmal Hisham NA, Khaledi H, Mohd Ali H
    Acta Crystallogr Sect E Struct Rep Online, 2010;67(Pt 1):m58.
    PMID: 21522576 DOI: 10.1107/S1600536810050889
    In the title compound, [Cu(NCS)(2)(C(13)H(19)N(3)O)], the Cu(II) ion is five-coordinated by the N,N',N''-tridentate Schiff base and the N atoms of two isothio-cyanate ligands in a square-pyramidal geometry. In the crystal, C-H⋯N, C-H⋯O and C-H⋯S inter-actions link adjacent mol-ecules into layers parallel to the ac plane. A weak inter-molecular π-π inter-action occurs between the aromatic rings with a centroid-centroid distance of 3.9412 (9) Å.
  5. Fulltext Bis{benzyl 3-[(1H-indol-3-yl)methyl-idene]dithio-carbazato-κN,S}palladium(II) N,N-dimethyl-formamide disolvate
    Khaledi H, Mohd Ali H
    Acta Crystallogr Sect E Struct Rep Online, 2010;67(Pt 1):m84.
    PMID: 21522600 DOI: 10.1107/S1600536810051780
    In the title compound, [Pd(C(17)H(14)N(3)S(2))(2)]·2C(3)H(7)NO, the deprotonated Schiff base ligand acts as an N,S-bidentate chelate, forming a five-membered ring with the metal atom. The Pd(II) ion, located on an inversion center, is four-coordinated by two of the Schiff base ligands in a square-planar geometry. In the crystal, the indolic NH groups are bonded to the dimethyl-formamide (DMF) solvent mol-ecules via an N-H⋯O inter-action. In addition, C-H⋯S inter-actions are observed.
  6. Fulltext 3-Nitro-1H-1,2,4-triazole
    Hemamalini M, Fun HK
    Acta Crystallogr Sect E Struct Rep Online, 2010;67(Pt 1):o15.
    PMID: 21522657 DOI: 10.1107/S1600536810049287
    The asymmetric unit of the title compound, C(2)H(2)N(4)O(2), contains two crystallographically independent mol-ecules in which the triazole rings are essentially planar, with maximum deviations of 0.003 (1) Å in both molecules. The dihedral angle between the two 1H-1,2,4-triazole rings is 56.58 (5)°. In the crystal, mol-ecules are linked via inter-molecular N-H⋯N and C-H⋯O hydrogen bonds, forming a supra-molecular chain along the b axis.
  7. Fulltext Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma
    Mohd Bakri M, Mohd Hussaini H, Rachel Holmes A, David Cannon R, Mary Rich A
    J Oral Microbiol, 2010 Dec 21;2.
    PMID: 21523221 DOI: 10.3402/jom.v2i0.5780
    BACKGROUND: Tobacco and alcohol are risk factors associated with cancer of the upper aerodigestive tract, but increasingly the role of infection and chronic inflammation is recognized as being significant in cancer development. Bacteria, particularly Helicobacter pylori, and viruses such as members of the human papilloma virus family and hepatitis B and C are strongly implicated as etiological factors in certain cancers. There is less evidence for an association between fungi and cancer, although it has been recognized for many years that white patches on the oral mucosa, which are infected with Candida, have a greater likelihood of undergoing malignant transformation than those that are not infected.

    OBJECTIVE: This article reviews the association between the development of oral squamous cell carcinoma in potentially malignant oral lesions with chronic candidal infection and describes mechanisms that may be involved in Candida-associated malignant transformation.

  8. An optimized method for extraction and detection of Coconut cadang-cadang viroid(CCCVd) from oil palm
    Mohammadi MR, Vadamalai G, Joseph H
    Commun. Agric. Appl. Biol. Sci., 2010;75(4):777-81.
    PMID: 21534490
    Coconut cadong-cadong viroid (CCCVd) causes the Lethal cadang-cadang disease of coconut palms in the Philippines and it is recently reported to be associated with the orange spotting disease on oil palm in Malaysia. The low concentration of the viroid RNA in oil palm as well as the high content of polyphenols and polysaccharides in this plant which interfere with the purification steps makes it difficult to extract and detect this viroid from oil palm. A previously described method was modified and optimized for extraction and detection of CCCVd from infected oil palms. Briefly, 7 g of leaf material was homogenized in a mortar or a blender using liquid nitrogen. 10 ml of extraction buffer (100 mM Tris-HCl pH 7.5, 100 mM NaCl, 10 mM EDTA) along with 100 mM 2-mercaptoethanol and 10 ml water saturated phenol was added to the frozen powder. After centrifuging at 4 degrees C, 4000 g for 30 min, the aqueous phase was extracted once more with phenol then once with chloroform-isoamyl alcohol (24:1). After adding sodium acetate, pH 5.6 to 200 mM, the mixture was precipitated with 2.5 vol ethanol overnight in -20 freezer and then the pellet was washed with 70% ethanol and air-dried. One milliliter of 8 M LiCl was added to the dried pellet and after shaking overnight at 4 degrees C and another centrifugation step the supernatant was collected and precipitated again with ethanol and then the resulting pellet was washed and air-dried. To carry out northern blotting, samples equivalent to 40 g of plant tissue were mixed with formamide buffer and loaded onto a 12% polyacrylamide gel containing 7 M urea and after separation by electrophoresis, were electroblotted onto membrane and fixed by UV cross-linking. Pre-hybridization and hybridization using hybridization buffer (50% formamide, 25%SSPE, 0.1% Ficol and PVP, 0.1 % SDS, 0.02 % DNA (5mg/ml)) was carried out at 45 degrees C for 90 min and 16 h, respectively followed by two low stringency washes (0.5 X SSC, 0.1% SDS, at room temperature for 5 min) and one high stringency wash (0.1X SSC, 0.1% SDS at 60 degrees C for 1 hour). In vitro synthesized DIG-labeled full-length CCCVd(-) RNA probe was used in hybridization step. DIG Nucleic Acid Detection Kit (Roche) instructions were followed for detection procedure and as a result the blue bands corresponding to the position of the viroid were appeared on the membrane. The result of this study showed the ability of DIG labeled probe in detection of the viroid and also provided a suitable extraction and hybridization method for the detection of CCCVd from oil palm.
    MeSH terms: Base Sequence; Cocos/virology*; Genetic Techniques*; Molecular Sequence Data; Philippines; Plant Diseases/virology*; RNA, Viral/genetics; RNA, Viral/isolation & purification*; Viroids/genetics; Viroids/isolation & purification*
  9. Fulltext Tetra-kis(μ(2)-2,2-dimethyl-propanoato-κO,O')bis-[(pyridine-κN)copper(II)]: a monoclinic polymorph
    Ozair LN, Abdullah N, Khaledi H, Tiekink ER
    Acta Crystallogr Sect E Struct Rep Online, 2010 Apr 30;66(Pt 5):m589-90.
    PMID: 21579064 DOI: 10.1107/S1600536810015060
    The structure of the dinuclear title complex, [Cu(2)(C(5)H(9)O(2))(4)(C(5)H(5)N)(2)], represents a monoclinic polymorph of the previously reported triclinic form [Blewett et al. (2006 ▶). Acta Cryst. E62, m420-m422]. Each carboxyl-ate group is bidentate bridging and the distorted octa-hedral geometry about each Cu(II) atom is completed by a pyridine N atom and the other Cu atom [Cu⋯Cu = 2.6139 (7) Å]. In the crystal, mol-ecules are connected into supra-molecular chains via π-π inter-actions formed by the pyridine rings [centroid-centroid distance = 3.552 (3) Å] and these are connected into a two-dimensional array in the ac plane by C-H⋯π contacts. One of the tert-butyl groups is disordered over two orientations in a 0.734 (6):0.266 (6) ratio.
  10. Fulltext 2-Chloro-3-nitro-pyridine
    Ng SW
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 5):o1020.
    PMID: 21579084 DOI: 10.1107/S1600536810011955
    In the title compound, C(5)H(3)ClN(2)O(2), the nitro group is twisted by 38.5 (2)° with respect to the pyridine ring. In the crystal, adjacent mol-ecules are linked by non-classical C-H⋯N and C-H⋯O hydrogen bonds, forming a layer motif.
  11. Fulltext 5,6-Di-2-thienyl-2,3-dihydro-pyrazine
    Hemamalini M, Fun HK
    Acta Crystallogr Sect E Struct Rep Online, 2010 Apr 14;66(Pt 5):o1062.
    PMID: 21579119 DOI: 10.1107/S1600536810012705
    In the title compound, C(12)H(10)N(2)S(2), which was synthesized by the reaction of 2,2'-thenil and ethyl-enediamine, the dihedral angle between the two thio-phene rings is 66.33 (9)°. In the crystal structure, inter-molecular C-H⋯N hydrogen bonds link the mol-ecules into infinite chains along the b axis and weak C-H⋯π inter-actions may further stabilize the structure.
  12. Fulltext 2-(4-Morpholine-carbothio-ylsulfan-yl)-acetic acid
    Lo KM, Ng SW
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 5):o1078.
    PMID: 21579132 DOI: 10.1107/S1600536810012602
    The asymmetric unit of the title compound, C(7)H(11)NO(3)S(2), contains two independent mol-ecules with similar mol-ecular structures. The morpholine ring adopts a chair conformation, and the C(2)N-C(=S)-S fragment is planar in the two independent mol-ecules (r.m.s. deviations = 0.01 and 0.02 Å). The two mol-ecules are disposed about a false center of inversion and are held together by a pair of O-H⋯O hydrogen bonds. The crystal studied was a racemic twin; the minor twin component refined to 17%.
  13. Fulltext 1-(2,3,4-Trihydroxy-benzyl-idene)-4-ethyl-thio-semicarbazide
    Shawish HB, Maah MJ, Ng SW
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 5):o1151.
    PMID: 21579198 DOI: 10.1107/S1600536810014078
    In the title mol-ecule, C(10)H(13)N(3)O(3)S, the thio-semicarbazide =N-NH-C(=S)-NH- fragment is twisted with respect to the aromatic ring [dihedral angle = 20.5 (1)°]. A weak N-H⋯S hydrogen bond [3.480 (1) Å] links two mol-ecules about a center of inversion to generate a ring. The hydr-oxy groups are engaged in inter-molecular hydrogen bonding; the O-H⋯O and O-H⋯S hydrogen bonds generate a layer motif.
  14. Fulltext 2-Amino-5-methyl-pyridinium 2-hydr-oxy-3,5-dinitro-benzoate
    Hemamalini M, Fun HK
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 5):o1194-5.
    PMID: 21579230 DOI: 10.1107/S1600536810014480
    In the title mol-ecular salt, C(6)H(9)N(2) (+)·C(7)H(3)N(2)O(7) (-), the 2-amino-5-methyl-pyridinium cation is essentially planar, with a maximum deviation of 0.023 (1) Å. There is an intra-molecular O-H⋯O hydrogen bond in the 3,5-dinitro-salicylate anion, which generates an S(6) ring motif. In the crystal, the protonated N atom and the 2-amino group are hydrogen bonded to the carboxyl-ate O atoms via a pair of N-H⋯O hydrogen bonds, forming an R(2) (2)(8) ring motif. Weak inter-molecular C-H⋯O inter-actions help to further stabilize the crystal structure.
  15. Fulltext Bis[(4-chloro-benz-yl)triphenyl-phospho-nium] tetra-chloridozincate(II) trihydrate
    Tan KW, Maah MJ, Ng SW
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 6):m690.
    PMID: 21579329 DOI: 10.1107/S1600536810018325
    The crystal structure of the title compound, (C(25)H(21)ClP)(2)[ZnCl(4)]·3H(2)O, consists of tetra-hedral phosphonium cations and tetra-hedral zincate anions; the water mol-ecules form weak hydrogen bonds to the anions. Two of the water mol-ecules are disordered over three sites in a 0.68:0.55:0.77 ratio.
  16. Fulltext 1-(2,3,4-Trihydroxy-benzyl-idene)thio-semicarbazide
    Shawish HB, Maah MJ, Ng SW
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 6):o1278.
    PMID: 21579378 DOI: 10.1107/S1600536810015850
    In the title mol-ecule, C(8)H(9)N(3)O(3)S, the thio-semicarbazide =N-NH-C(=S)-NH- fragment is twist a different degree of twist in the three independent mol-ecules [dihedral angles = 7.6 (1), 11.6 (1) and 20.7 (1)°]. Intra-molecular O-H⋯N and O-H⋯O hydrogen bonds occur. In the crystal, the hydr-oxy and amino groups are hydrogen-bond donors and the O-H⋯O, O-H⋯S and N-H⋯O hydrogen bonds generate a layer motif.
  17. Fulltext 5,22-Stigmastadien-3β-yl p-toluene-sulfonate
    Ketuly KA, Hadi AH, Khaledi H, Tiekink ER
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 6):o1336.
    PMID: 21579426 DOI: 10.1107/S1600536810016661
    The asymmetric unit of the title compound {systematic name: (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methyl-hept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodeca-hydro-1H-cyclo-penta-[a]phenanthren-3-yl p-toluene-sulfonate}, C(36)H(54)O(3)S, comprises two independent mol-ecules that differ significantly in terms of the relative orientations of the peripheral groups; the conformation about the C=C bond of the side chain is E. In the crystal, mol-ecules associate into linear supra-molecular chains aligned along the a axis via C-H⋯O inter-actions.
  18. Fulltext 2-Amino-5-chloro-pyridine-fumaric acid (1/2)
    Hemamalini M, Fun HK
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 6):o1416-7.
    PMID: 21579495 DOI: 10.1107/S1600536810018192
    The asymmetric unit of the title compound, C(5)H(5)ClN(2)·0.5C(4)H(4)O(4), comprises a neutral 2-amino-5-chloro-pyridine mol-ecule and one half of a fumaric acid mol-ecule which lies on an inversion center. The dihedral angle between the pyridine ring and the plane formed by the fumaric acid mol-ecule is 3.22 (8)°. The 2-amino-5-chloro-pyridine mol-ecule is planar, with a maximum deviation of 0.004 (1) Å for the pyridine N atom. In the crystal, the 2-amino-5-chloro-pyridine mol-ecules inter-act with the carboxyl groups of fumaric acid mol-ecules through N-H⋯O and O-H⋯N hydrogen bonds, forming centrosymmetric R(2) (2)(8) ring motifs and another N-H⋯O hydrogen bond links these motifs into a two-dimensional network parallel to (100).
  19. Fulltext 2-Amino-5-chloro-pyridinium salicylate
    Hemamalini M, Fun HK
    Acta Crystallogr Sect E Struct Rep Online, 2010 May 22;66(Pt 6):o1418-9.
    PMID: 21579496 DOI: 10.1107/S1600536810018210
    In the crystal structure of the title salt, C(5)H(6)ClN(2) (+)·C(7)H(5)O(3) (-), the protonated N atom and the 2-amino group of the cation are hydrogen bonded to the carboxyl-ate O atoms via a pair of N-H⋯O hydrogen bonds, forming R(2) (2)(8) ring motifs. These motifs are centrosymmetrically paired via N-H⋯O hydrogen bonds, forming a complementary donor-donor-acceptor-acceptor (DDAA) array. A typical intra-molecular O-H⋯O hydrogen bond is also observed in the salicylate anion. The crystal structure is further stabilized by weak C-H⋯π inter-actions.
  20. Fulltext 2-Amino-5-methyl-pyridinium picolinate 0.63-hydrate
    Hemamalini M, Fun HK
    Acta Crystallogr Sect E Struct Rep Online, 2010;66(Pt 6):o1420-1.
    PMID: 21579497 DOI: 10.1107/S1600536810018180
    The asymmetric unit of the title compound, C(6)H(9)N(2) (+)·C(6)H(4)NO(2) (-)·0.63H(2)O, contains two crystallographically independent 2-amino-5-methyl-pyridinium cations, a pair of picolinate anions and two water mol-ecules, one with an occupancy of 0.25. Both the 2-amino-5-methyl-pyridine mol-ecules are protonated at the pyridine N atoms. In the crystal structure, the cations, anions and water mol-ecules are linked via N-H⋯O, N-H⋯N and O-H⋯O hydrogen bonds, as well as by C-H⋯O contacts, forming a chain along the b axis. In addition, weak π-π inter-actions are observed between pyridinium rings, with centroid-centroid distances of 3.5306 (13) Å.
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