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Dengue surveillance using gravid oviposition sticky (GOS) trap and dengue non-structural 1 (NS1) antigen test in Malaysia: randomized controlled trial

Selvarajoo S 1 , Liew JWK 1 , Chua TH 2 , Tan W 1 , Zaki RA 3 , Ngui R 1 Show all authors , Sulaiman WYW 1 , Ong PS 4 , Vythilingam I 5

Affiliations 

  • 1 Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia
  • 2 Department of Pathobiology and Medical Diagnostics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia
  • 3 Department of Social and Preventive Medicine, Faculty of Medicine, Centre for Epidemiology and Evidence Based Practice, Universiti Malaya, 50603, Kuala Lumpur, Malaysia
  • 4 Petaling Jaya City Council, 46675, Petaling Jaya, Selangor, Malaysia
  • 5 Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. indrav@um.edu.my
Sci Rep, 2022 01 12;12(1):571.
PMID: 35022501 DOI: 10.1038/s41598-021-04643-4

Abstract

Dengue remains a major public threat and existing dengue control/surveillance programs lack sensitivity and proactivity. More efficient methods are needed. A cluster randomized controlled trial was conducted for 18 months to determine the efficacy of using a combination of gravid oviposition sticky (GOS) traps and dengue non-structural 1 (NS1) antigen for early surveillance of dengue among Aedes mosquito. Eight residential apartments were randomly assigned into intervention and control groups. GOS traps were placed at the intervention apartments weekly to trap Aedes mosquitoes and these tested for dengue NS1 antigen. When dengue-positive pool was detected, the community were notified and advised to execute protective measures. Fewer dengue cases were recorded in the intervention group than the control. Detection of NS1-positive mosquitoes was significantly associated with GOS Aedes index (rs = 0.68, P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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